Movicol Plain (Sodium Hydrogen Carbonate, Potassium Chloride, Sodium Chloride, Macrogol 3350)

• Movicol Plain is an osmotic laxative used to manage conditions that involve reduced bowel motility.
• Constipation: softens stool and promotes regular bowel movements.
• Opioid‑induced constipation: counteracts reduced intestinal water content caused by opioid therapy.
• Functional constipation: improves stool consistency and frequency in chronic idiopathic cases.

• Macrogol 3350 creates an osmotic gradient in the intestinal lumen by retaining water molecules, which increases the volume and fluidity of the stool. The resulting higher intraluminal pressure stimulates peristalsis, leading to more frequent and softer bowel movements without being absorbed systemically.

Movicol Plain may cause a range of adverse reactions, most of which are mild and transient.

Common Side Effects

• Abdominal bloating or distension
• Flatulence
• Nausea or mild stomach discomfort
• Diarrhoea or loose stools
• Thirst or increased fluid intake
• Electrolyte imbalance (e.g., low potassium)

Serious or Rare Side Effects

• Severe dehydration
• Significant electrolyte disturbances (hypernatremia, hyponatremia)
• Allergic reactions such as rash, itching, or swelling
• Persistent abdominal pain
• Blood in stool

• Before using Movicol Plain, consider the following safety measures.
• Renal impairment: monitor kidney function and fluid status.
• Electrolyte disorders: assess serum electrolytes, especially potassium and sodium.
• Severe constipation or bowel obstruction: avoid use until obstruction is ruled out.
• Pregnancy and breastfeeding: consult a healthcare professional before use.
• Pediatric use: dosage must be determined by a prescriber based on age and weight.
• Store at ambient temperature: keep below 25°C, retain in original container, protect from moisture and direct sunlight.

Movicol Plain can interact with other medicines that affect fluid or electrolyte balance.

Major Interactions (Avoid)

• Loop diuretics (e.g., furosemide): risk of severe electrolyte depletion.
• Sodium‑containing laxatives: may cause excessive sodium load.
• Mineral supplements (e.g., potassium chloride): potential for hyperkalaemia.

Moderate Interactions (Monitor Closely)

• Antacids containing magnesium or aluminium: may alter absorption.
• Certain antibiotics (e.g., quinolones): reduced plasma concentration.
• Cardiovascular drugs (e.g., digoxin): monitor serum levels due to electrolyte shifts.