Product image of Movicol (Sodium Hydrogen Carbonate, Potassium Chloride, Sodium Chloride, Macrogol 3350) supplied by GNH India

Movicol

Active Ingredient:
Sodium Hydrogen Carbonate, Potassium Chloride, Sodium Chloride, Macrogol 3350
Origin:
EU

Movicol (Sodium Hydrogen Carbonate, Potassium Chloride, Sodium Chloride, Macrogol 3350)

Macrogol 3350 (polyethylene glycol 3350) with electrolytes, the active ingredient in Movicol, is an osmotic laxative presented as a powder for oral solution for oral use. It treats constipation, occasional constipation and fecal impaction in adults and children.

GNH India supplies Movicol as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Norgine Italia S.R.L.

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Indications & Clinical Uses

Movicol, an osmotic laxative, is used to manage conditions related to reduced bowel motility and stool hardness.

  • Constipation: softens stool and facilitates regular bowel movements.
  • Occasional constipation: relieves infrequent difficulty passing stool.
  • Fecal impaction: helps to soften impacted stool and promote evacuation.

How It Works

  • Macrogol 3350 is a high‑molecular‑weight polyethylene glycol that is minimally absorbed in the gastrointestinal tract. It creates an osmotic gradient that retains water in the intestinal lumen, while the accompanying electrolytes (sodium, potassium, chloride) maintain fluid balance. The increased intraluminal water softens feces and stimulates peristalsis, promoting bowel evacuation.

Side Effects

Common Side Effects

  • Abdominal bloating: feeling of fullness or swelling in the abdomen.
  • Nausea: mild sensation of wanting to vomit.
  • Flatulence: increased intestinal gas.
  • Abdominal cramps: intermittent stomach pain.
  • Diarrhoea: loose, watery stools.
  • Thirst: increased desire to drink fluids.

Serious or Rare Side Effects

  • Severe electrolyte imbalance: abnormal sodium or potassium levels.
  • Allergic reaction: rash, itching, swelling, or difficulty breathing.
  • Severe abdominal pain: persistent, intense pain requiring medical attention.
  • Dehydration: excessive fluid loss leading to dizziness or low blood pressure.

Precautions & Warnings

Before using Movicol, consider the following precautions:

  • Renal function assessment: evaluate kidney health to avoid fluid overload.
  • Electrolyte monitoring: check sodium and potassium levels during prolonged use.
  • Elderly patients: use with caution as they may be more susceptible to dehydration.
  • Bowel obstruction: avoid if a mechanical blockage is suspected.
  • Dosage adherence: do not exceed the amount prescribed by a healthcare professional.
  • Store at ambient temperature: keep in the original pack, protect from moisture.

Avoid Interactions

Movicol may interact with other medicines as follows:

Major Interactions (Avoid)

  • Other osmotic laxatives: combined use can cause severe fluid loss.
  • Diuretics: may exacerbate electrolyte disturbances.
  • Magnesium‑containing laxatives: increase risk of dehydration.

Moderate Interactions (Monitor Closely)

  • Antacids containing aluminium: may reduce laxative effectiveness.
  • Non‑steroidal anti‑inflammatory drugs (NSAIDs): can increase risk of renal impairment.
  • ACE inhibitors: require monitoring of blood pressure and electrolytes.

Frequently Asked Questions

Movicol is an oral powder that, when dissolved in water, acts as an osmotic laxative. It is indicated for the treatment of constipation, occasional constipation, and fecal impaction, helping to soften stool and promote regular bowel movements in adults and children.

The macrogol 3350 component is a large polyethylene glycol molecule that is not absorbed. It draws water into the intestinal lumen by osmosis, while the added electrolytes maintain fluid balance. The resulting increase in intestinal water softens the stool and stimulates peristalsis, facilitating evacuation.

The dose of Movicol is individualized. A healthcare professional determines the appropriate amount based on the patient’s age, severity of constipation, and clinical response. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Safety data for Movicol in pregnancy and lactation are limited. It should only be used if the potential benefit justifies any possible risk to the fetus or infant. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss use with their healthcare provider.

To order Movicol, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide. After verification of trade or institutional credentials, the sales team will provide pricing, availability, shipping details and any necessary import documentation.

Compared with stimulant laxatives, Movicol works by osmotic water retention rather than stimulating intestinal muscle activity, resulting in a gentler, more physiologic stool softening. It also contains electrolytes, which helps maintain fluid balance, whereas some other osmotic agents lack this feature.

Movicol powder should be stored at ambient temperature, below 25 °C, in its original packaging to protect it from moisture. Keep the container tightly closed and out of direct sunlight. No refrigeration is required.

The powder is dissolved in a specified volume of water, usually 125 ml, and stirred until fully mixed. The solution is then consumed orally, preferably on an empty stomach or as directed by a healthcare professional.

Serious risks include severe electrolyte imbalance, particularly low sodium or potassium, which can affect heart rhythm and muscle function. Rarely, allergic reactions such as rash, swelling, or breathing difficulty may occur. Prompt medical attention is required if these symptoms develop.

Movicol should be avoided in individuals with known hypersensitivity to any component, in patients with a complete bowel obstruction, or in those with severe renal impairment without medical supervision. It is also contraindicated in patients who require strict fluid restriction.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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