Product image of Mowel (Mycophenolate Mofetil) supplied by GNH India

Mowel

Active Ingredient:
Mycophenolate Mofetil
Origin:
EU

Mowel (Mycophenolate Mofetil)

Mycophenolate Mofetil, the active ingredient in Mowel, is an antimetabolite presented as an oral formulation for oral use. It is employed to prevent graft rejection in organ transplantation and to treat lupus nephritis by suppressing the immune response. The drug works by inhibiting inosine monophosphate dehydrogenase, a key enzyme in lymphocyte proliferation, thereby reducing the activity of T and B cells that drive rejection and renal inflammation.

GNH India supplies Mowel as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Panacea Biotec Germany Gmbh

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Indications & Clinical Uses

Mowel (mycophenolate mofetil) is used in immunosuppressive therapy to manage conditions that involve unwanted immune activation.

  • Organ transplantation (kidney, heart, liver, pancreas): helps prevent acute graft rejection and supports long‑term graft survival.
  • Lupus nephritis: reduces renal inflammation, proteinuria and disease progression.
  • Bone marrow transplantation (GVHD prophylaxis): lowers the risk of graft‑versus‑host disease after hematopoietic stem‑cell transplant.

How It Works

  • Mycophenolate mofetil is a pro‑drug that is converted to mycophenolic acid, which selectively inhibits inosine monophosphate dehydrogenase (IMPDH). This enzyme is essential for de novo guanosine nucleotide synthesis in lymphocytes. By blocking IMPDH, the drug suppresses proliferation of activated T and B cells, leading to reduced immune‑mediated damage in transplanted organs and autoimmune kidney disease.

Side Effects

Adverse reactions to Mowel vary in frequency and severity.

Common Side Effects

  • Nausea: mild to moderate gastrointestinal upset.
  • Diarrhea: watery stools, sometimes requiring fluid replacement.
  • Headache: transient, often resolves with continued therapy.
  • Tremor: fine shaking of hands or limbs.
  • Infections: increased susceptibility to bacterial, viral or fungal infections.
  • Leukopenia: reduced white‑blood‑cell count, may be asymptomatic.

Serious or Rare Side Effects

  • Severe infection: opportunistic infections such as Pneumocystis jirovecii pneumonia.
  • Malignancy: heightened risk of lymphoproliferative disorders.
  • Bone‑marrow suppression: anemia, thrombocytopenia, pancytopenia.
  • Hepatic toxicity: elevated liver enzymes or hepatitis.
  • Progressive multifocal leukoencephalopathy (PML): rare demyelinating disease of the CNS.

Precautions & Warnings

Before initiating Mowel, clinicians should consider several safety measures.

  • Monitor blood counts: perform regular complete blood count tests to detect leukopenia or anemia.
  • Assess liver function: check hepatic enzymes periodically.
  • Avoid live vaccines: live attenuated vaccines may cause infection while immunosuppressed.
  • Use effective contraception: teratogenic risk is unknown; pregnancy should be avoided.
  • Adjust dose in renal impairment: reduced clearance may require dose modification.
  • Store at below 25°C: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Mowel can interact with other medicines, altering efficacy or safety.

Major Interactions (Avoid)

  • Azathioprine: additive bone‑marrow suppression.
  • Cyclosporine or tacrolimus: increased nephrotoxicity and infection risk.
  • Live vaccines: heightened risk of vaccine‑derived disease.
  • Cholestyramine or colestipol: may reduce mycophenolate absorption.

Moderate Interactions (Monitor Closely)

  • Warfarin: potential alteration of anticoagulant effect, monitor INR.
  • Antacids containing aluminum or magnesium: may affect drug bioavailability.
  • Rifampin: induces metabolism, possibly lowering mycophenolate levels.
  • Fluconazole: inhibits metabolism, may increase exposure.
  • ACE inhibitors: monitor renal function when combined with nephrotoxic agents.

Frequently Asked Questions

Mowel contains mycophenolate mofetil and is used as an immunosuppressant to prevent graft rejection after organ transplantation and to treat lupus nephritis by reducing immune‑mediated kidney inflammation.

Mycophenolate mofetil is converted to mycophenolic acid, which blocks inosine monophosphate dehydrogenase (IMPDH). This inhibition stops the synthesis of guanosine nucleotides needed for lymphocyte proliferation, thereby dampening T‑ and B‑cell activity.

The prescribed dose of Mowel is determined by the treating physician based on the specific indication, patient weight, renal function and other clinical factors. Patients should follow the dosing instructions provided by their healthcare professional.

The safety of mycophenolate mofetil in pregnancy and lactation has not been established. Women of child‑bearing potential should use effective contraception, and breastfeeding is generally not recommended while taking this medication.

To order Mowel, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with calcineurin inhibitors such as cyclosporine, mycophenolate mofetil offers a different mechanism—IMPDH inhibition—resulting in less nephrotoxicity but a higher risk of gastrointestinal upset and bone‑marrow suppression. Choice of therapy depends on the transplant protocol and patient tolerance.

Mowel should be stored at temperatures below 25 °C, in its original packaging, protected from moisture and direct sunlight. Do not store in a bathroom or near heat sources, and keep the container tightly closed when not in use.

Mowel is taken orally, usually with food to reduce gastrointestinal irritation. The tablets are swallowed whole with a full glass of water; they should not be crushed, chewed or dissolved unless specifically instructed by a healthcare professional.

Serious risks include severe infections, opportunistic infections such as Pneumocystis jirovecii pneumonia, malignancies, bone‑marrow suppression leading to anemia or pancytopenia, and rare cases of progressive multifocal leukoencephalopathy (PML). Patients should be monitored closely for these events.

Mowel should be avoided in patients with known hypersensitivity to mycophenolate mofetil or any component of the formulation, in those with uncontrolled infections, and in individuals receiving live vaccines. Caution is also advised for patients with severe renal or hepatic impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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