Product image of Moxiclav (Amoxicillin, Clavulanic Acid) supplied by GNH India

Moxiclav

Active Ingredient:
Amoxicillin, Clavulanic Acid
Origin:
EU

Moxiclav (Amoxicillin, Clavulanic Acid)

Amoxicillin, the active ingredient in Moxiclav, is a beta‑lactam antibiotic presented as an injectable formulation for intravenous use. Combined with clavulanic acid, a beta‑lactamase inhibitor, the product expands coverage against beta‑lactamase‑producing bacteria and is used to treat serious infections such as respiratory, urinary, skin and soft‑tissue, and intra‑abdominal infections in both adult and pediatric patients.

GNH India supplies Moxiclav as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide. The company provides regulatory‑approved batches to meet the needs of healthcare institutions across multiple regions.

Manufacturer / TM Owner

Medochemie Hellas Sa

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Indications & Clinical Uses

Moxiclav is indicated for bacterial infections affecting several organ systems, where it provides broad‑spectrum coverage.

  • Respiratory tract infections: effective against community‑acquired pneumonia and bronchitis.
  • Urinary tract infections: treats complicated and uncomplicated infections caused by susceptible organisms.
  • Skin and soft‑tissue infections: resolves cellulitis, abscesses, and wound infections.
  • Intra‑abdominal infections: used for peritonitis and intra‑abdominal sepsis caused by mixed flora.

How It Works

  • Amoxicillin inhibits bacterial cell‑wall synthesis by binding to penicillin‑binding proteins, leading to cell lysis. Clavulanic acid acts as a suicide inhibitor of beta‑lactamase enzymes, protecting amoxicillin from enzymatic degradation and extending its antibacterial spectrum against beta‑lactamase‑producing organisms.

Side Effects

Adverse reactions may occur with any antibiotic therapy.

Common Side Effects

  • Diarrhea: mild to moderate loose stools.
  • Nausea: occasional upset stomach.
  • Vomiting: transient episodes.
  • Rash: mild skin erythema.
  • Headache: transient cephalgia.
  • Elevated liver enzymes: transient transaminase rise.

Serious or Rare Side Effects

  • Anaphylaxis: severe allergic reaction requiring immediate medical attention.
  • Stevens‑Johnson syndrome: rare severe skin and mucous membrane disorder.
  • Clostridioides difficile colitis: severe intestinal inflammation.
  • Hepatotoxicity: significant liver injury.
  • Neutropenia: marked reduction in neutrophil count.

Precautions & Warnings

Use of Moxiclav requires careful assessment of patient factors and proper handling.

  • Renal impairment: dose adjustment may be necessary.
  • Hepatic impairment: monitor liver function tests.
  • Allergy history: avoid in patients with known β‑lactam allergy.
  • Pregnancy and lactation: prescribe only if benefit outweighs potential risk.
  • Concomitant antibiotics: assess for possible antagonism.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Moxiclav can interact with several medicines, influencing efficacy or safety.

Major Interactions (Avoid)

  • Allopurinol: increased risk of severe skin reactions.
  • Methotrexate: heightened toxicity and bone‑marrow suppression.
  • Warfarin: enhanced anticoagulant effect, monitor INR closely.

Moderate Interactions (Monitor Closely)

  • Oral contraceptives: reduced hormonal efficacy, consider backup method.
  • Probenecid: decreased renal excretion, may raise plasma levels.
  • Aminoglycosides: potential antagonistic effect on bacterial killing.

Frequently Asked Questions

Moxiclav is used for serious bacterial infections such as community‑acquired pneumonia, complicated urinary tract infections, skin and soft‑tissue infections, and intra‑abdominal sepsis. It provides broad‑spectrum coverage against organisms that produce beta‑lactamase enzymes.

Amoxicillin blocks bacterial cell‑wall synthesis by binding to penicillin‑binding proteins, causing cell lysis. Clavulanic acid inhibits beta‑lactamase enzymes that many bacteria produce, protecting amoxicillin from degradation and extending its antimicrobial activity.

The dosage of Moxiclav is determined by the prescribing clinician based on the type and severity of infection, patient age, weight, and renal function. Only a qualified healthcare professional should set the appropriate regimen.

Safety data are limited, so Moxiclav should be used in pregnancy or while breastfeeding only when the potential benefit to the mother outweighs any possible risk to the fetus or infant. The prescriber must evaluate each case individually.

To request Moxiclav, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and import documentation.

Moxiclav combines a standard beta‑lactam (amoxicillin) with a beta‑lactamase inhibitor (clavulanic acid), offering broader coverage than amoxicillin alone and many other penicillins. This makes it effective against beta‑lactamase‑producing strains that would resist single‑agent therapy.

Moxiclav for injection should be stored at 2‑8 °C, protected from light, and must not be frozen or shaken. Keep the product in its original packaging until ready for use to maintain stability.

Moxiclav is given intravenously by a healthcare professional. The injection is administered slowly over several minutes, following aseptic technique, and the infusion rate may be adjusted according to the patient’s condition and tolerance.

Serious risks include severe allergic reactions such as anaphylaxis, life‑threatening skin conditions like Stevens‑Johnson syndrome, Clostridioides difficile‑associated colitis, significant liver injury, and blood‑cell abnormalities such as neutropenia. Immediate medical attention is required if any of these occur.

Patients with a known hypersensitivity to amoxicillin, clavulanic acid, or any other β‑lactam antibiotics should avoid Moxiclav. It is also contraindicated in individuals with a history of severe reactions to beta‑lactamase inhibitors.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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