Product image of Moxifloxacin Acino (Moxifloxacin Hydrochloride) supplied by GNH India

Moxifloxacin Acino

Active Ingredient:
Moxifloxacin Hydrochloride
Origin:
EU

Moxifloxacin Acino (Moxifloxacin Hydrochloride)

Moxifloxacin, the active ingredient in Moxifloxacin Acino, is a fluoroquinolone antibiotic presented as a solution for injection for intravenous use. It treats a range of serious bacterial infections in adult patients.

GNH India supplies Moxifloxacin Acino as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Acino Ag

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Indications & Clinical Uses

Moxifloxacin is a broad‑spectrum fluoroquinolone used to treat bacterial infections in the respiratory, skin and intra‑abdominal systems.

  • Community‑acquired pneumonia: effective treatment of infection caused by susceptible bacteria.
  • Acute bacterial sinusitis: eradicates the causative pathogens and relieves sinus inflammation.
  • Acute bacterial exacerbation of chronic bronchitis: reduces bacterial load and improves airflow.
  • Complicated skin and skin‑structure infections: targets Gram‑positive and Gram‑negative organisms.
  • Complicated intra‑abdominal infections: provides coverage for mixed aerobic and anaerobic flora.

How It Works

  • Moxifloxacin inhibits bacterial DNA gyrase (topoisomerase II) and topoisomerase IV, enzymes essential for DNA replication, transcription and repair. By stabilizing the enzyme‑DNA complex, it prevents the resealing of DNA strands, leading to bacterial cell death and a bactericidal effect against susceptible organisms.

Side Effects

Moxifloxacin may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Nausea: transient gastrointestinal upset.
  • Diarrhea: loose stools, often self‑limiting.
  • Headache: mild to moderate intensity.
  • Dizziness: occasional vertigo or light‑headedness.
  • Rash: mild skin erythema or pruritus.
  • Transient elevation of liver enzymes: mild, reversible increase in ALT/AST.

Serious or Rare Side Effects

  • Tendon rupture: especially Achilles, may occur during or after therapy.
  • QT interval prolongation: risk of ventricular arrhythmias.
  • Severe allergic reactions: anaphylaxis, angioedema.
  • Clostridioides difficile‑associated diarrhea: potentially life‑threatening colitis.
  • Hepatic failure: rare but serious liver injury.
  • Stevens‑Johnson syndrome/toxic epidermal necrolysis: severe skin reactions.

Precautions & Warnings

Before initiating therapy, consider patient‑specific factors and monitor for adverse events.

  • Pregnancy: Category C – use only if potential benefits justify the risk to the fetus.
  • Renal impairment: dose adjustment may be required in patients with reduced clearance.
  • History of tendon disorders: avoid use due to risk of tendon rupture.
  • Concurrent QT‑prolonging drugs: monitor ECG and electrolytes closely.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Moxifloxacin can interact with several drug classes; awareness helps prevent toxicity.

Major Interactions (Avoid)

  • Co‑administration with other fluoroquinolones: increased risk of cumulative toxicity.
  • Concurrent use of drugs that prolong the QT interval (e.g., macrolides, antiarrhythmics): heightened arrhythmia risk.
  • Antacids containing aluminum or magnesium: markedly reduce moxifloxacin absorption.

Moderate Interactions (Monitor Closely)

  • Non‑steroidal anti‑inflammatory drugs (NSAIDs): may increase central nervous system side effects.
  • Warfarin: potential enhancement of anticoagulant effect; monitor INR regularly.

Frequently Asked Questions

Moxifloxacin Acino is indicated for serious bacterial infections such as community‑acquired pneumonia, acute bacterial sinusitis, acute bacterial exacerbations of chronic bronchitis, complicated skin and skin‑structure infections, and complicated intra‑abdominal infections. It is administered intravenously to patients who require rapid, systemic antibacterial therapy.

Moxifloxacin blocks bacterial DNA gyrase and topoisomerase IV, enzymes that unwind and reseal DNA during replication and transcription. Inhibiting these enzymes prevents bacterial DNA synthesis, leading to cell death. This mechanism gives moxifloxacin a broad‑spectrum, bactericidal effect against many Gram‑positive and Gram‑negative organisms.

The dosage of Moxifloxacin Acino is determined by the prescribing clinician based on the infection type, severity, patient weight, renal function and other clinical factors. Healthcare professionals follow local guidelines and product labeling to select the appropriate intravenous dose and treatment duration.

Moxifloxacin is classified as Pregnancy Category C, meaning it should be used only if the potential benefit justifies the potential risk to the fetus. Limited data are available for breastfeeding; the drug may pass into breast milk, so a risk‑benefit assessment by the prescriber is essential.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain handling if needed) and required import documentation.

Moxifloxacin offers a broader spectrum against Gram‑positive organisms and better activity in respiratory infections compared with older fluoroquinolones such as ciprofloxacin. It also has a more favorable dosing schedule for intravenous use, but like all fluoroquinolones, it shares class‑related safety considerations that must be weighed against alternatives.

Moxifloxacin Acino should be stored refrigerated at 2‑8 °C, protected from light, and must not be frozen or shaken. Maintaining the cold chain preserves drug stability and potency until the point of administration.

Moxifloxacin Acino is supplied as a sterile solution for injection and is administered intravenously by a qualified healthcare professional. The infusion rate and duration are set by the prescriber according to the patient’s clinical condition and institutional protocols.

Serious risks include tendon rupture, QT‑interval prolongation leading to potentially fatal arrhythmias, severe allergic reactions such as anaphylaxis, Clostridioides difficile‑associated colitis, and rare but life‑threatening skin reactions like Stevens‑Johnson syndrome. Patients should be monitored closely for any signs of these events.

Moxifloxacin Acino is contraindicated in patients with a known hypersensitivity to moxifloxacin or other fluoroquinolones. It should also be avoided in individuals with a history of tendon disorders related to fluoroquinolone use, uncontrolled arrhythmias, or those taking multiple QT‑prolonging agents without appropriate monitoring.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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