Product image of Moxifloxacina Aurobindo (Moxifloxacin Hydrochloride) supplied by GNH India

Moxifloxacina Aurobindo

Active Ingredient:
Moxifloxacin Hydrochloride
Origin:
EU

Moxifloxacina Aurobindo (Moxifloxacin Hydrochloride)

Moxifloxacin, the active ingredient in Moxifloxacina Aurobindo, is a fluoroquinolone antibiotic presented as an oral tablet for oral use. It treats bacterial infections such as community‑acquired pneumonia, acute bacterial sinusitis, acute bacterial exacerbation of chronic bronchitis, complicated skin and skin‑structure infections, and (off‑label) uncomplicated urinary tract infections in adult patients.

GNH India supplies Moxifloxacina Aurobindo as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Aurobindo Pharma (Italia) S.R.L.

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Indications & Clinical Uses

  • Moxifloxacina Aurobindo is a fluoroquinolone antibiotic used to treat bacterial infections in several organ systems.
  • Community‑acquired pneumonia: achieves clinical cure and bacterial eradication.
  • Acute bacterial sinusitis: reduces symptoms and clears the infecting pathogen.
  • Acute bacterial exacerbation of chronic bronchitis: improves lung function and shortens disease course.
  • Complicated skin and skin‑structure infections: eliminates causative bacteria and promotes wound healing.
  • Uncomplicated urinary tract infections (off‑label): provides microbiological clearance in selected adult cases.

How It Works

  • Moxifloxacin inhibits bacterial DNA gyrase (topoisomerase II) and topoisomerase IV, enzymes essential for DNA replication, transcription, and repair. By stabilizing the enzyme‑DNA complex, it prevents the resealing of DNA strands, leading to bacterial cell death. This dual targeting confers broad‑spectrum activity against Gram‑positive, Gram‑negative, and atypical respiratory pathogens.

Side Effects

Moxifloxacina Aurobindo may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Nausea
  • Diarrhea
  • Headache
  • Dizziness
  • Abdominal pain
  • Rash

Serious or Rare Side Effects

  • Tendon rupture or tendinitis
  • QT interval prolongation leading to arrhythmia
  • Clostridioides difficile‑associated colitis
  • Severe allergic reactions (anaphylaxis, Stevens‑Johnson syndrome)
  • Hepatic toxicity (elevated transaminases, hepatitis)
  • Peripheral neuropathy

Precautions & Warnings

  • Before prescribing Moxifloxacina Aurobindo, clinicians should consider several safety measures.
  • Assess renal and hepatic function: adjust therapy if impairment is present.
  • Avoid use in patients with known hypersensitivity to fluoroquinolones.
  • Monitor for tendon pain or swelling: discontinue if tendonitis or rupture occurs.
  • Evaluate QT interval in patients with cardiac risk factors.
  • Avoid concomitant use with other QT‑prolonging drugs.
  • Store at ambient temperature below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Moxifloxacina Aurobindo can interact with several medicines, requiring careful management.

Major Interactions (Avoid)

  • Antacids containing aluminum or magnesium: markedly reduce moxifloxacin absorption.
  • Warfarin: may increase INR and bleeding risk.
  • Corticosteroids: heightened risk of tendon rupture.
  • Other fluoroquinolones (e.g., ciprofloxacin): additive tendon toxicity.
  • Drugs that prolong QT interval (e.g., macrolides, certain antiarrhythmics): risk of serious cardiac arrhythmias.

Moderate Interactions (Monitor Closely)

  • Theophylline: may raise plasma concentrations, leading to toxicity.
  • Cyclosporine: increased exposure may require dose adjustment.
  • Diabetes medications: potential alteration of glycemic control.

Frequently Asked Questions

Moxifloxacina Aurobindo is indicated for adult patients with community‑acquired pneumonia, acute bacterial sinusitis, acute bacterial exacerbations of chronic bronchitis, complicated skin and skin‑structure infections, and, in some cases, uncomplicated urinary tract infections when prescribed off‑label.

Moxifloxacin blocks bacterial DNA gyrase and topoisomerase IV, enzymes required for DNA replication and transcription. By preventing the resealing of DNA strands, it leads to bacterial cell death and provides broad‑spectrum antibacterial activity.

The dose of Moxifloxacina Aurobindo is determined by the prescribing clinician based on the infection type, severity, patient age, renal and hepatic function, and local treatment guidelines. Patients should follow the exact regimen provided by their healthcare professional.

The pregnancy category for moxifloxacin is not definitively established. Because fluoroquinolones may affect fetal cartilage development, they are generally avoided unless the potential benefit outweighs the risk. Breastfeeding mothers should consult a physician, as the drug can be excreted in milk.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Moxifloxacin offers a broader spectrum against atypical respiratory pathogens and a longer half‑life, allowing once‑daily dosing for many infections. Compared with older fluoroquinolones such as ciprofloxacin, it has enhanced activity against Gram‑positive organisms and a lower propensity for certain drug‑resistance mechanisms.

Moxifloxacina Aurobindo tablets should be stored at ambient temperature below 25 °C, in the original packaging, and protected from moisture and direct sunlight. Do not store in bathrooms or near heat sources.

The medication is taken orally, usually with a full glass of water. It can be taken with or without food, but antacids containing aluminum or magnesium should be spaced at least two hours apart to avoid reduced absorption.

Serious risks include tendon rupture or tendinitis, QT‑interval prolongation leading to potentially fatal arrhythmias, severe allergic reactions such as anaphylaxis or Stevens‑Johnson syndrome, Clostridioides difficile‑associated colitis, hepatic toxicity, and peripheral neuropathy. Patients should seek immediate medical attention if they experience related symptoms.

Moxifloxacina Aurobindo is contraindicated in individuals with a known hypersensitivity to moxifloxacin or any fluoroquinolone, those with a history of tendon disorders related to fluoroquinolone use, and patients taking other QT‑prolonging agents when the risk of arrhythmia is high. Caution is also advised for patients with severe renal or hepatic impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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