Product image of Mulado (Metformin Hydrochloride) supplied by GNH India

Mulado

Active Ingredient:
Metformin Hydrochloride
Origin:
EU

Mulado (Metformin Hydrochloride)

Metformin, the active ingredient in Mulado, is a biguanide presented as an oral tablet for oral administration. It helps lower elevated blood glucose levels by reducing hepatic glucose production and improving insulin sensitivity, and is indicated for the long‑term management of type 2 diabetes mellitus in adult patients.

GNH India supplies Mulado as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable, on‑time delivery to meet global healthcare needs.

Manufacturer / TM Owner

Zentiva, K.S.

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Indications & Clinical Uses

Metformin is a biguanide antidiabetic that primarily targets glucose metabolism in type 2 diabetes mellitus.

  • Type 2 diabetes mellitus: improves glycemic control and reduces HbA1c levels.
  • Prediabetes (impaired fasting glucose): helps delay progression to overt diabetes.
  • Polycystic ovary syndrome: reduces insulin resistance and may restore ovulatory cycles.

How It Works

  • Metformin acts by inhibiting mitochondrial respiratory-chain complex I, which decreases hepatic gluconeogenesis and lowers hepatic glucose output. It also enhances peripheral insulin sensitivity by increasing glucose uptake in muscle and adipose tissue and improves lipid metabolism, contributing to overall glycemic control without directly stimulating insulin secretion.

Side Effects

Metformin is generally well tolerated, but a range of adverse reactions can occur.

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Diarrhea: loose stools, especially during treatment initiation.
  • Abdominal discomfort: cramping or bloating.
  • Metallic taste: transient alteration of taste perception.
  • Weight loss: modest reduction in body weight.
  • Vitamin B12 deficiency: decreased absorption with long‑term use.

Serious or Rare Side Effects

  • Lactic acidosis: rare but life‑threatening metabolic acidosis.
  • Severe hypoglycemia: usually when combined with insulin or sulfonylureas.
  • Hepatic failure: rare hepatic dysfunction.
  • Allergic reactions: rash, pruritus, or angioedema.
  • Metabolic acidosis: non‑lactic acid accumulation.
  • Pancreatitis: very uncommon inflammation of the pancreas.

Precautions & Warnings

Metformin requires careful assessment of patient factors before and during therapy.

  • Renal function assessment: evaluate eGFR and avoid use in severe renal impairment.
  • Hepatic disease monitoring: use cautiously in patients with liver dysfunction.
  • Cardiovascular status: consider risk of lactic acidosis in unstable heart failure.
  • Concomitant alcohol intake: limit alcohol to reduce lactic acidosis risk.
  • Pregnancy and lactation: assess benefit‑risk ratio with obstetric guidance.
  • Store at ambient temperature: keep below 25°C in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Metformin may interact with several medicines, altering its efficacy or safety.

Major Interactions (Avoid)

  • Iodinated contrast agents: risk of acute renal failure and lactic acidosis.
  • Cimetidine: can increase metformin plasma concentrations.
  • Alcohol excess: potentiates lactic acidosis.

Moderate Interactions (Monitor Closely)

  • Beta‑blockers: may mask symptoms of hypoglycemia.
  • Thiazide diuretics: can attenuate glucose‑lowering effect.
  • ACE inhibitors or ARBs: monitor renal function and potassium levels.
  • Digoxin: may increase risk of hypoglycemia when combined with insulin.

Frequently Asked Questions

Mulado contains metformin hydrochloride and is used to improve blood glucose control in adults with type 2 diabetes mellitus. It works as part of a comprehensive diabetes management plan that may include diet, exercise, and other medications.

Metformin reduces hepatic glucose production, enhances peripheral insulin sensitivity, and increases glucose uptake by muscle and fat cells. These actions lower fasting and post‑prandial blood glucose without stimulating insulin secretion.

The dose of Mulado is individualized by the prescribing clinician based on the patient’s renal function, glycemic targets, and tolerability. The prescriber determines the appropriate strength and dosing schedule.

Metformin is classified as pregnancy category B in many regions, indicating no proven risk in animal studies, but human data are limited. Use only if the potential benefit justifies the potential risk, and discuss breastfeeding considerations with a healthcare professional.

To order Mulado, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Compared with sulfonylureas, metformin does not cause insulin‑mediated hypoglycemia and often promotes modest weight loss. Unlike newer GLP‑1 receptor agonists, it is an oral tablet and is less costly, making it a first‑line option for many patients with type 2 diabetes.

Store Mulado at ambient temperature, preferably below 25 °C, in the original packaging to protect it from moisture and light. Keep the container tightly closed and out of reach of children.

Mulado is taken orally, usually with meals to reduce gastrointestinal upset. The tablet should be swallowed whole with a glass of water; it is not intended for crushing, chewing, or dissolving.

The most serious risk is lactic acidosis, a rare but potentially fatal condition that can occur in patients with severe renal or hepatic impairment, excessive alcohol intake, or acute medical illness. Prompt medical attention is required if symptoms such as rapid breathing, muscle pain, or abdominal discomfort develop.

Mulado is contraindicated in patients with severe renal impairment (eGFR < 30 mL/min/1.73 m²), known hypersensitivity to metformin, acute or chronic metabolic acidosis, including diabetic ketoacidosis, and in those receiving iodinated contrast studies without appropriate renal monitoring.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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