Product image of Mulado Prolong (Metformin Hydrochloride) supplied by GNH India

Mulado Prolong

Active Ingredient:
Metformin Hydrochloride
Origin:
EU

Mulado Prolong (Metformin Hydrochloride)

Metformin Hydrochloride, the active ingredient in Mulado Prolong, is a biguanide presented as an oral tablet for oral use. It treats type 2 diabetes mellitus in adults.
GNH India supplies Mulado Prolong as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Zentiva, K.S.

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Indications & Clinical Uses

Metformin Hydrochloride is used in the management of disorders affecting glucose metabolism, primarily type 2 diabetes mellitus.

  • Type 2 diabetes mellitus: Improves glycemic control by lowering fasting and post‑prandial blood glucose levels.

How It Works

  • Metformin Hydrochloride acts primarily by inhibiting hepatic gluconeogenesis, thereby reducing hepatic glucose output. It also enhances peripheral insulin sensitivity, increasing glucose uptake in muscle and adipose tissue, and modestly decreases intestinal glucose absorption, collectively contributing to lower blood glucose concentrations.

Side Effects

Metformin Hydrochloride may cause a range of adverse reactions, most of which are mild and transient.

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Diarrhea: loose stools, often early in therapy.
  • Abdominal discomfort: cramping or bloating.
  • Metallic taste: transient alteration of taste perception.

Serious or Rare Side Effects

  • Lactic acidosis: a rare but life‑threatening metabolic disturbance.
  • Severe skin reactions: such as Stevens‑Johnson syndrome.
  • Hepatic dysfunction: abnormal liver enzymes.
  • Vitamin B12 deficiency: may develop with long‑term use.

Precautions & Warnings

Metformin Hydrochloride requires careful assessment of patient factors and monitoring to minimize risks.

  • Renal function assessment: evaluate eGFR before initiating and periodically thereafter.
  • Lactic acidosis risk: avoid in patients with significant renal or hepatic impairment.
  • Alcohol consumption: limit intake to reduce lactic acidosis risk.
  • Pregnancy and lactation: use only if benefits outweigh potential risks.
  • Store at ambient temperature: keep in the original pack, protect from moisture and heat.

Avoid Interactions

Metformin Hydrochloride can interact with several medicines, altering its efficacy or safety profile.

Major Interactions (Avoid)

  • Iodinated contrast agents: may precipitate acute renal dysfunction.
  • Cimetidine: increases metformin plasma concentrations.
  • Alcohol: heightens risk of lactic acidosis.
  • Renally toxic drugs (e.g., NSAIDs): may impair metformin clearance.

Moderate Interactions (Monitor Closely)

  • Beta‑blockers: may mask symptoms of hypoglycemia.
  • Thiazide diuretics: can attenuate glucose‑lowering effect.
  • ACE inhibitors: require monitoring of renal function.

Frequently Asked Questions

Mulado Prolong contains metformin hydrochloride, which is prescribed to improve blood glucose control in adults with type 2 diabetes mellitus. It helps lower both fasting and post‑meal blood sugar levels as part of a comprehensive diabetes management plan.

Metformin hydrochloride reduces the liver’s production of glucose, enhances the sensitivity of muscle and fat cells to insulin, and modestly decreases intestinal absorption of glucose. These combined actions result in lower circulating blood glucose concentrations.

The dosage of Mulado Prolong is individualized by the prescribing healthcare professional based on the patient’s clinical condition, renal function, and response to therapy. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Metformin may be used during pregnancy or lactation only when the potential benefits justify any potential risks to the fetus or infant. The decision should be made by the treating physician in consultation with the patient.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Metformin, the active ingredient in Mulado Prolong, belongs to the biguanide class and is often first‑line therapy for type 2 diabetes because of its efficacy, low risk of hypoglycemia, and favorable impact on weight. Other classes, such as sulfonylureas or DPP‑4 inhibitors, have different mechanisms and side‑effect profiles.

Mulado Prolong should be stored at ambient temperature, below 25 °C, in its original packaging to protect it from moisture and light. Keep the product out of reach of children and do not use it after the expiry date.

Mulado Prolong is taken orally, usually with meals to reduce gastrointestinal discomfort. The tablet should be swallowed whole with a glass of water and not crushed or chewed unless otherwise directed by a healthcare professional.

The most serious adverse reaction is lactic acidosis, a rare but potentially fatal condition that can occur in patients with severe renal or hepatic impairment, excessive alcohol intake, or other risk factors. Prompt medical attention is required if symptoms such as rapid breathing, muscle pain, or abdominal discomfort develop.

Mulado Prolong is contraindicated in patients with severe renal impairment (eGFR < 30 mL/min/1.73 m²), known hypersensitivity to metformin, acute or chronic metabolic acidosis, and in those who have experienced lactic acidosis while on metformin therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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