Product image of Multibic (Sodium Hydrogen Carbonate, Magnesium Chloride Hexahydrate, Potassium Chloride, Sodium Chloride, Calc) supplied by GNH India

Multibic

Active Ingredient:
Sodium Hydrogen Carbonate, Magnesium Chloride Hexahydrate, Potassium Chloride, Sodium Chloride, Calc
Origin:
EU

Multibic (Sodium Hydrogen Carbonate, Magnesium Chloride Hexahydrate, Potassium Chloride, Sodium Chloride, Calc)

Sodium hydrogen carbonate, the active ingredient in Multibic, is an electrolyte solution presented as an intravenous solution for haemodialysis use. It helps maintain fluid and acid‑base balance in patients undergoing renal replacement therapy.
GNH India supplies Multibic as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals and dialysis centres worldwide.

Manufacturer / TM Owner

Fresenius Medical Care Deutschland Gmbh

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Indications & Clinical Uses

Multibic is an electrolyte solution used in renal replacement therapy and related dialysis procedures.

  • Haemodialysis: provides essential electrolytes and buffering capacity to maintain acid‑base equilibrium during treatment.
  • Renal replacement therapy: supports fluid balance and electrolyte homeostasis in patients with end‑stage kidney disease.
  • Chronic kidney disease (dialysis phase): helps stabilize serum potassium, magnesium, calcium and bicarbonate levels during ongoing dialysis sessions.

How It Works

  • Multibic delivers sodium, potassium, magnesium, calcium and bicarbonate ions directly into the bloodstream during haemodialysis. The bicarbonate component buffers excess hydrogen ions, correcting metabolic acidosis, while the electrolytes replenish those removed by the dialyzer, preserving osmotic balance and supporting normal cardiac and neuromuscular function.

Side Effects

Multibic may be associated with infusion‑related reactions.

Common Side Effects

  • Mild hypotension or transient hypertension
  • Nausea or mild gastrointestinal discomfort
  • Headache or dizziness
  • Transient electrolyte shift (e.g., mild hyperkalemia)
  • Flushing or warmth at the infusion site
  • Mild metabolic alkalosis

Serious or Rare Side Effects

  • Severe hyperkalemia or hypermagnesemia leading to cardiac arrhythmia
  • Anaphylactic or severe allergic reaction
  • Severe metabolic alkalosis with respiratory compensation
  • Volume overload causing pulmonary edema
  • Severe hypertension or hypotension requiring intervention
  • Coagulopathy or bleeding abnormalities

Precautions & Warnings

When using Multibic, clinicians should observe standard dialysis safety measures.

  • Monitor electrolytes: check serum sodium, potassium, magnesium, calcium and bicarbonate before and during infusion.
  • Adjust infusion rate: tailor to patient fluid status and cardiovascular tolerance.
  • Contraindications: avoid in patients with uncontrolled hyperkalemia or severe metabolic alkalosis.
  • Compatibility: verify compatibility with other intravenous solutions to prevent precipitation.
  • Storage: Store at below 25°C: keep in original container, protect from light and moisture.

Avoid Interactions

Multibic can interact with other medications that affect electrolyte balance or acid‑base status.

Major Interactions (Avoid)

  • Concurrent high‑dose potassium supplements: risk of severe hyperkalemia.
  • Calcium‑containing IV solutions: potential precipitation with bicarbonate.
  • Magnesium‑containing drugs: may cause hypermagnesemia.
  • Sodium bicarbonate oral preparations: excess alkalinity.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors or ARBs: enhanced potassium retention.
  • Loop or thiazide diuretics: altered electrolyte clearance.
  • NSAIDs: impact renal perfusion and electrolyte handling.
  • Antihypertensives: may require dose adjustment due to fluid shifts.
  • Blood transfusions: monitor for citrate‑related calcium changes.

Frequently Asked Questions

Multibic is an intravenous electrolyte solution used during haemodialysis and other renal replacement therapy procedures to replenish essential ions and provide buffering capacity, helping maintain fluid and acid‑base balance in patients with kidney failure.

The formulation supplies sodium, potassium, magnesium, calcium and bicarbonate ions directly into the bloodstream. Bicarbonate buffers excess hydrogen ions, correcting metabolic acidosis, while the electrolytes replace those removed by the dialyzer, supporting normal cellular and cardiac function.

The dose of Multibic is determined by the prescribing clinician based on the patient’s dialysis prescription, electrolyte status and fluid requirements. It is administered intravenously as part of the haemodialysis circuit under medical supervision.

Safety of Multibic in pregnancy or lactation has not been established. Use should be considered only if the potential benefit justifies any potential risk to the mother or infant, and decisions should be made by the treating physician.

To order Multibic, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Multibic combines sodium bicarbonate with magnesium, potassium, calcium and sodium chloride, offering a comprehensive electrolyte profile in a single bag. Compared with solutions that provide only bicarbonate or limited electrolytes, Multibic can reduce the need for multiple infusions and simplify fluid management during dialysis.

Multibic should be stored at temperatures below 25 °C, protected from direct sunlight, moisture and physical damage. Keep the solution in its original packaging until use and inspect for particulate matter or discoloration before administration.

Multibic is administered intravenously, typically added to the haemodialysis circuit or infused directly into the patient’s bloodstream under the control of a dialysis machine. Administration is performed by trained healthcare professionals following the prescribed dialysis protocol.

Serious risks include severe electrolyte disturbances such as hyperkalemia, hypermagnesemia or hypercalcemia, which can lead to cardiac arrhythmias, as well as severe metabolic alkalosis, volume overload and rare anaphylactic reactions. Continuous monitoring during infusion is essential.

Multibic should be avoided in patients with uncontrolled hyperkalemia, severe metabolic alkalosis, known hypersensitivity to any component of the solution, or in those receiving incompatible intravenous medications that may precipitate when mixed.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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