Product image of Multibic (Sodium Hydrogen Carbonate, Magnesium Chloride Hexahydrate, Potassium Chloride, Sodium Chloride, Calc) supplied by GNH India

Multibic

Active Ingredient:
Sodium Hydrogen Carbonate, Magnesium Chloride Hexahydrate, Potassium Chloride, Sodium Chloride, Calc
Origin:
EU

Multibic (Sodium Hydrogen Carbonate, Magnesium Chloride Hexahydrate, Potassium Chloride, Sodium Chloride, Calc)

Sodium hydrogen carbonate, magnesium chloride hexahydrate, potassium chloride, sodium chloride and calcium, the active ingredients in Multibic, are an electrolyte solution presented as an intravenous solution for haemodialysis use. It provides essential electrolytes and buffering capacity to patients undergoing renal replacement therapy.

GNH India supplies Multibic as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Fresenius Medical Care Deutschland Gmbh

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Indications & Clinical Uses

Multibic is an electrolyte solution used in renal replacement therapy to support patients undergoing haemodialysis.

  • Hemodialysis: supplies sodium, potassium, calcium, magnesium and bicarbonate to maintain fluid and electrolyte balance during treatment.
  • Electrolyte replacement during dialysis: corrects deficits of key ions that can arise from the dialysis process.
  • Acid‑base balance maintenance: provides buffering capacity to help keep blood pH within the normal range throughout the session.

How It Works

  • Multibic delivers a balanced mixture of sodium, potassium, calcium, magnesium and bicarbonate ions directly into the extracorporeal circuit. The bicarbonate component buffers hydrogen ions, helping to maintain physiological pH, while the electrolytes replace those removed by diffusion across the dialysis membrane, thereby preserving plasma electrolyte concentrations and supporting cellular function during haemodialysis.

Side Effects

Multibic may be associated with transient adverse reactions related to its composition and rate of administration.

Common Side Effects

  • Hypotension: drop in blood pressure during infusion.
  • Nausea: mild gastrointestinal discomfort.
  • Vomiting: occasional emesis.
  • Headache: transient cranial pain.
  • Metallic taste: perception of metal in mouth.
  • Muscle cramps: involuntary limb contractions.

Serious or Rare Side Effects

  • Hyperkalemia: elevated serum potassium levels.
  • Metabolic alkalosis: excessive bicarbonate leading to high pH.
  • Cardiac arrhythmia: irregular heart rhythm due to electrolyte shifts.
  • Anaphylactic reaction: severe allergic response.
  • Electrolyte overload: excessive sodium or calcium accumulation.
  • Seizures: neurologic events linked to severe electrolyte imbalance.

Precautions & Warnings

When using Multibic, clinicians should observe specific safety measures.

  • Monitor electrolytes: check serum sodium, potassium, calcium and magnesium before and after dialysis.
  • Adjust composition: tailor the solution based on individual laboratory results.
  • Cardiac caution: use carefully in patients with known heart disease or arrhythmias.
  • Infusion rate: avoid rapid administration that could cause hemodynamic instability.
  • Contraindication: do not use in patients with severe hyperkalemia without correction.
  • Store at below 25°C: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Multibic can interact with other agents that affect electrolyte or acid‑base status.

Major Interactions (Avoid)

  • High‑potassium supplements: may cause dangerous hyperkalemia.
  • Additional sodium bicarbonate infusions: risk of metabolic alkalosis.
  • Calcium‑containing IV solutions: can lead to calcium overload.
  • Magnesium‑containing drugs: may result in hypermagnesemia.
  • ACE inhibitors or ARBs: potentiate potassium retention.

Moderate Interactions (Monitor Closely)

  • Diuretics: alter fluid and electrolyte balance, requiring close monitoring.
  • Beta‑blockers: may mask signs of hypotension.
  • Anticoagulants used during dialysis: watch for bleeding risk when combined with rapid volume shifts.

Frequently Asked Questions

Multibic is an intravenous electrolyte solution designed for use during haemodialysis. It supplies essential ions and buffering capacity to help maintain electrolyte balance and proper acid‑base status in patients receiving renal replacement therapy.

The formulation contains sodium, potassium, calcium, magnesium and bicarbonate ions. During dialysis, these ions replace those removed across the dialysis membrane, while bicarbonate buffers excess hydrogen ions, together preserving plasma electrolyte concentrations and stabilising blood pH.

The prescribed volume and concentration of Multibic are determined by the treating physician based on the patient’s laboratory values, dialysis prescription and clinical condition. Dosing is individualized and not fixed.

Safety data for Multibic in pregnancy and lactation are limited. The product should only be used if the potential benefit to the mother outweighs any possible risk to the fetus or infant, and the decision should be made by a qualified healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and required import documentation.

Multibic offers a balanced combination of sodium, potassium, calcium, magnesium and bicarbonate, similar to other commercial dialysis fluids. Its specific ion concentrations are formulated to meet EU standards and may differ slightly from alternatives, allowing clinicians to select the product that best matches their patients’ electrolyte targets.

Store Multibic at below 25 °C in its original container, protected from moisture and direct sunlight. Do not freeze. Inspect the solution for particulate matter or discoloration before use and discard if any abnormalities are observed.

Multibic is administered intravenously as part of the haemodialysis circuit. The solution is added to the dialysate or directly infused into the extracorporeal blood line according to the dialysis machine’s programming and the clinician’s prescription.

Serious risks include hyperkalemia, metabolic alkalosis, severe electrolyte overload (especially sodium or calcium), cardiac arrhythmias and anaphylactic reactions. Prompt monitoring of serum electrolytes and patient vital signs during dialysis helps mitigate these risks.

Multibic should be avoided in patients with untreated severe hyperkalemia, known hypersensitivity to any component of the solution, or those in whom rapid shifts in electrolyte balance could be hazardous without close monitoring.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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