Product image of Multibic (Sodium Hydrogen Carbonate, Magnesium Chloride Hexahydrate, Potassium Chloride, Sodium Chloride, Calc) supplied by GNH India

Multibic

Active Ingredient:
Sodium Hydrogen Carbonate, Magnesium Chloride Hexahydrate, Potassium Chloride, Sodium Chloride, Calc
Origin:
EU

Multibic (Sodium Hydrogen Carbonate, Magnesium Chloride Hexahydrate, Potassium Chloride, Sodium Chloride, Calc)

Sodium hydrogen carbonate, together with magnesium chloride hexahydrate, potassium chloride, sodium chloride and calcium, the active ingredients in Multibic, are an electrolyte solution presented as a sterile solution for haemodialysis and intravenous use. It provides essential ions to maintain electrolyte and acid‑base balance during renal replacement therapy in patients undergoing dialysis.

GNH India supplies Multibic as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres and clinics worldwide.

Manufacturer / TM Owner

Fresenius Medical Care Deutschland Gmbh

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Indications & Clinical Uses

Multibic is used in renal replacement therapy and intravenous fluid management to correct electrolyte disturbances.

  • Haemodialysis: maintains electrolyte and acid‑base balance during the procedure.
  • Intravenous electrolyte replacement: restores sodium, potassium, magnesium, calcium and chloride in patients with deficits.
  • Continuous renal replacement therapy: supports fluid and electrolyte homeostasis in critically ill patients.

How It Works

  • Multibic delivers sodium, potassium, magnesium, calcium and chloride ions directly into the bloodstream or dialysis circuit. The sodium hydrogen carbonate component provides bicarbonate buffering, helping to correct metabolic acidosis. Potassium and magnesium chloride replenish extracellular potassium and magnesium, while calcium and sodium chloride contribute to overall electrolyte balance. Together, these ions stabilize membrane potentials, support cardiac and neuromuscular function, and maintain osmotic equilibrium during renal replacement therapy.

Side Effects

Multibic may be associated with several adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Mild hypotension
  • Nausea
  • Transient headache

Serious or Rare Side Effects

  • Severe hyperkalemia
  • Anaphylactic reaction
  • Cardiac arrhythmia

Precautions & Warnings

When using Multibic, clinicians should observe specific safety measures.

  • Assess electrolyte levels: monitor serum sodium, potassium, magnesium and calcium before and during infusion.
  • Adjust infusion rate: tailor to patient’s fluid status and cardiac condition.
  • Renal function: consider residual kidney function when dosing.
  • Cardiac status: observe for arrhythmias, especially in patients with pre‑existing heart disease.
  • Use aseptic technique: prevent contamination of the solution.
  • Store at ambient temperature: keep in original container, protect from light and moisture.

Avoid Interactions

Multibic can interact with other medicines; awareness of major and moderate interactions is important.

Major Interactions (Avoid)

  • Potassium‑sparing diuretics: risk of hyperkalemia.
  • Calcium‑containing medications: risk of hypercalcemia.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors: monitor serum potassium.
  • Beta‑blockers: may potentiate hypotensive effects.
  • Other intravenous electrolyte solutions: avoid cumulative electrolyte overload.

Frequently Asked Questions

Multibic is an electrolyte solution employed during haemodialysis and as an intravenous infusion to replace lost sodium, potassium, magnesium, calcium and chloride. It helps maintain electrolyte balance and acid‑base homeostasis in patients undergoing renal replacement therapy or who require rapid correction of electrolyte deficits.

Sodium hydrogen carbonate (bicarbonate) acts as a buffering agent. When infused, it combines with hydrogen ions to form carbonic acid, which quickly dissociates to water and carbon dioxide. This process helps correct metabolic acidosis that can occur during dialysis, supporting normal blood pH while also contributing sodium to the overall electrolyte composition.

The prescribed dose of Multibic is set by the treating clinician based on the patient’s individual electrolyte profile, fluid status, type of dialysis modality and overall clinical condition. Laboratory values such as serum sodium, potassium, magnesium and calcium guide the volume and rate of infusion to achieve the desired balance.

Safety data for Multibic in pregnancy and lactation are limited. Because it contains multiple electrolytes that can affect maternal and fetal fluid balance, it should only be used when clearly indicated and prescribed by a healthcare professional familiar with the risks and benefits for the mother and the unborn or nursing child.

To order Multibic, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if required) and any necessary import documentation.

Standard dialysis fluids often contain a fixed electrolyte composition, whereas Multibic offers a customizable blend of sodium, potassium, magnesium, calcium and chloride, allowing clinicians to tailor therapy to individual patient needs. Its inclusion of bicarbonate provides additional buffering capacity, which can be advantageous in managing metabolic acidosis during treatment.

Multibic should be stored at ambient temperature, preferably below 25 °C. Keep the solution in its original, sealed container, protect it from direct sunlight and moisture, and avoid freezing. Follow any additional handling instructions on the label to maintain sterility and solution integrity.

Multibic is supplied as a sterile solution for injection. It can be added to the dialysis circuit as a dialysate component or infused intravenously through a controlled infusion set. Administration is performed by qualified healthcare personnel, who set the appropriate flow rate and monitor the patient’s vital signs and electrolyte levels throughout the procedure.

The most serious risks include severe electrolyte disturbances such as hyperkalemia or hypermagnesemia, which can lead to cardiac arrhythmias, and rare anaphylactic reactions. Prompt monitoring of serum electrolytes and patient observation during infusion are essential to detect and manage these potentially life‑threatening events.

Multibic should be avoided in patients with known hypersensitivity to any of its components, in those with uncontrolled hyperkalemia or hypermagnesemia, and in individuals for whom rapid shifts in fluid or electrolyte balance could exacerbate cardiac or neurological conditions. Clinicians must evaluate each patient’s medical history before initiating therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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