Product image of Multibic (Sodium Hydrogen Carbonate, Magnesium Chloride Hexahydrate, Potassium Chloride, Sodium Chloride, Calc) supplied by GNH India

Multibic

Active Ingredient:
Sodium Hydrogen Carbonate, Magnesium Chloride Hexahydrate, Potassium Chloride, Sodium Chloride, Calc
Origin:
EU

Multibic (Sodium Hydrogen Carbonate, Magnesium Chloride Hexahydrate, Potassium Chloride, Sodium Chloride, Calc)

Sodium Hydrogen Carbonate, the active ingredient in Multibic, is a dialysis solution presented as a solution for injection for haemodialysis and intravenous use. It provides electrolytes and buffering capacity to maintain acid‑base balance during haemodialysis in patients with renal failure.

GNH India supplies Multibic as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres and dialysis clinics worldwide.

Manufacturer / TM Owner

Fresenius Medical Care Deutschland Gmbh

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Indications & Clinical Uses

Multibic is used in the dialysis and renal replacement therapy setting to manage electrolyte and acid‑base balance.

  • Haemodialysis: supports electrolyte homeostasis and buffering during the procedure.
  • Renal replacement therapy: supplies essential ions to patients undergoing chronic dialysis.
  • Acute kidney injury requiring dialysis: helps stabilize plasma chemistry while renal function recovers.

How It Works

  • Multibic delivers a balanced mixture of sodium hydrogen carbonate, magnesium chloride, potassium chloride, sodium chloride and calcium ions. The solution buffers excess hydrogen ions, corrects metabolic acidosis, and restores plasma osmolarity and electrolyte concentrations, thereby preserving acid‑base equilibrium and cellular function during haemodialysis.

Side Effects

Multibic may be associated with infusion‑related reactions and electrolyte disturbances.

Common Side Effects

  • Hypotension: transient drop in blood pressure during rapid infusion.
  • Mild electrolyte shifts: transient hypernatremia, hypomagnesemia or mild hyperkalemia.
  • Metabolic alkalosis: mild increase in blood pH after buffering.
  • Infusion site irritation: redness or discomfort at the catheter site.

Serious or Rare Side Effects

  • Severe hyperkalemia: can precipitate cardiac arrhythmia.
  • Anaphylactic reaction: rare but may cause airway compromise.
  • Cardiac arrhythmia: associated with abrupt electrolyte changes.
  • Severe metabolic acidosis/alkalosis: extreme pH shifts requiring urgent correction.

Precautions & Warnings

When using Multibic, clinicians should observe several safety measures.

  • Assess electrolyte status: monitor serum Na+, K+, Mg2+ before and during infusion.
  • Adjust composition: tailor the solution based on individual patient laboratory values.
  • Avoid rapid infusion: limit infusion rate to prevent hypotension and sudden electrolyte shifts.
  • Use aseptic technique: ensure sterile handling to avoid contamination.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Multibic can interact with other agents that affect electrolyte balance.

Major Interactions (Avoid)

  • High‑dose potassium supplements: risk of dangerous hyperkalemia.
  • Calcium‑containing intravenous solutions: potential calcium overload.

Moderate Interactions (Monitor Closely)

  • Loop diuretics: may amplify electrolyte losses.
  • ACE inhibitors or ARBs: can increase serum potassium levels.
  • Beta‑blockers: may mask hypotensive responses during infusion.

Frequently Asked Questions

Multibic is a prescription dialysis solution used during haemodialysis and other renal replacement therapies to provide essential electrolytes and buffering capacity, helping to maintain acid‑base balance and plasma osmolarity in patients with kidney failure.

Sodium Hydrogen Carbonate acts as a buffering agent that neutralises excess hydrogen ions, correcting metabolic acidosis. Together with magnesium, potassium, sodium and calcium ions, it restores normal electrolyte concentrations and supports cellular function during dialysis.

The prescribed volume and rate of Multibic infusion are determined by the treating physician based on the patient’s weight, laboratory values and the specific dialysis protocol. Dosage is individualized and should follow the clinician’s orders.

Safety data for Multibic in pregnancy or lactation are limited. It should only be used if the potential benefit to the mother outweighs any possible risk to the fetus or infant, and the decision must be made by the prescribing healthcare professional.

To order Multibic, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and import documentation.

Multibic offers a balanced electrolyte composition with sodium hydrogen carbonate for buffering, similar to other commercial dialysis fluids. Its specific ion concentrations may differ, providing clinicians flexibility to match patient needs, while maintaining regulatory compliance and GMP standards.

Multibic should be stored at 2‑8 °C, protected from light, and must not be frozen or shaken. Keep the solution in its original packaging until use and discard any product that appears discoloured or contaminated.

Multibic is supplied as a sterile solution for injection and is administered intravenously through the dialysis circuit. The infusion rate and total volume are set by the dialysis machine according to the prescribed treatment protocol.

Serious risks include severe electrolyte disturbances such as hyperkalemia or calcium overload, which can lead to cardiac arrhythmias, as well as rare anaphylactic reactions. Continuous monitoring of vital signs and laboratory parameters is essential during treatment.

Multibic should be avoided in patients with known hypersensitivity to any of its components, those with uncontrolled electrolyte imbalances that cannot be corrected, or individuals for whom rapid shifts in plasma osmolarity are contraindicated. Clinical judgment is required for each case.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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