Product image of Multibic (Sodium Hydrogen Carbonate, Magnesium Chloride Hexahydrate, Potassium Chloride, Sodium Chloride, Calc) supplied by GNH India

Multibic

Active Ingredient:
Sodium Hydrogen Carbonate, Magnesium Chloride Hexahydrate, Potassium Chloride, Sodium Chloride, Calc
Origin:
EU

Multibic (Sodium Hydrogen Carbonate, Magnesium Chloride Hexahydrate, Potassium Chloride, Sodium Chloride, Calc)

Sodium hydrogen carbonate, magnesium chloride hexahydrate, potassium chloride, sodium chloride and calcium, the active ingredients in Multibic, are an electrolyte solution presented as a solution for intravenous infusion for haemodialysis use. It provides buffering capacity and electrolyte balance during renal replacement therapy.

GNH India supplies Multibic as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Fresenius Medical Care Deutschland Gmbh

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Indications & Clinical Uses

Multibic is used in renal replacement therapy to maintain electrolyte and acid‑base homeostasis during dialysis.

  • Hemodialysis: helps preserve plasma electrolyte concentrations and buffer capacity during the procedure.
  • Renal replacement therapy: supports patients undergoing continuous or intermittent dialysis by supplying essential ions.
  • Acute kidney injury requiring dialysis: provides rapid correction of electrolyte disturbances and metabolic acidosis.

How It Works

  • Multibic delivers a balanced mixture of sodium, potassium, magnesium, calcium and bicarbonate ions directly into the bloodstream during haemodialysis. The bicarbonate component buffers excess hydrogen ions, correcting metabolic acidosis, while the cations restore plasma osmolarity and maintain cellular function. This combined electrolyte and buffering action helps stabilize acid‑base status and prevents shifts that could compromise cardiovascular stability during renal replacement therapy.

Side Effects

Multibic may be associated with several adverse reactions, most of which are related to electrolyte shifts or infusion characteristics.

Common Side Effects

  • Hypernatremia: elevated serum sodium levels.
  • Hyperkalemia: increased potassium concentration.
  • Metabolic alkalosis: excessive bicarbonate leading to high pH.
  • Infusion site irritation: redness or discomfort at the catheter.
  • Hypotension: drop in blood pressure during rapid infusion.

Serious or Rare Side Effects

  • Cardiac arrhythmia: caused by abrupt electrolyte changes.
  • Severe hypercalcemia: excessive calcium levels.
  • Anaphylactic reaction: rare hypersensitivity to solution components.
  • Pulmonary edema: fluid overload in susceptible patients.
  • Thrombophlebitis: vein inflammation with clot formation.

Precautions & Warnings

When using Multibic, clinicians should observe specific safety measures to minimize risks.

  • Monitor electrolytes: regularly check serum sodium, potassium, calcium, magnesium and bicarbonate.
  • Adjust infusion rate: tailor speed to patient volume status and cardiac function.
  • Caution in heart failure: avoid rapid volume expansion.
  • Avoid in severe hyperkalemia: may worsen potassium excess.
  • Contraindicated in known hypersensitivity to any component.
  • Store at below 25°C: keep in original container, protect from moisture and direct sunlight.

Avoid Interactions

Multibic can interact with other medications that affect electrolyte balance or acid‑base status.

Major Interactions (Avoid)

  • Concurrent hypertonic saline: risk of severe hypernatremia.
  • Potassium‑sparing diuretics: may precipitate dangerous hyperkalemia.
  • Calcium‑containing IV solutions: can cause precipitation and hypercalcemia.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors or ARBs: may enhance potassium retention.
  • Loop diuretics: can lead to rapid shifts in magnesium and calcium.
  • NSAIDs: may affect renal handling of electrolytes.
  • Other bicarbonate preparations: increase risk of metabolic alkalosis.
  • Blood transfusions: monitor for additive electrolyte load.

Frequently Asked Questions

Multibic is an intravenous electrolyte solution used during haemodialysis and other forms of renal replacement therapy. It supplies essential ions and bicarbonate to maintain electrolyte balance and correct acid‑base disturbances in patients whose kidneys are unable to perform these functions.

The combination of sodium hydrogen carbonate, magnesium chloride, potassium chloride, sodium chloride and calcium delivers bicarbonate for buffering excess acid and provides key cations that restore plasma osmolarity. This helps stabilize pH and supports cellular activity while patients undergo dialysis.

The dose of Multibic is determined by the prescribing clinician based on the patient’s weight, dialysis modality, and current electrolyte levels. It is administered intravenously as an infusion during the dialysis session, with the exact volume and rate set by the healthcare professional.

Safety of Multibic in pregnancy or lactation has not been fully established. It should only be used if the potential benefit to the mother outweighs any possible risk to the fetus or infant, and the decision must be made by the treating physician.

To order Multibic, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and import documentation.

Multibic offers a balanced mix of sodium, potassium, magnesium, calcium and bicarbonate in a single infusion, whereas some alternatives provide only one or two of these components. This comprehensive formulation can reduce the need for multiple additives, simplifying the dialysis protocol while ensuring adequate electrolyte and buffering support.

Multibic should be stored at temperatures below 25 °C, protected from moisture, direct sunlight and extreme temperature fluctuations. Keep the solution in its original packaging until use and inspect for particulate matter or discoloration before administration.

Multibic is administered intravenously during haemodialysis. The solution is added to the dialysis circuit or infused directly into the patient’s bloodstream according to the prescribing clinician’s instructions, with infusion rate adjusted to the individual’s clinical status.

Serious risks include severe electrolyte disturbances such as hyperkalemia, hypernatremia, hypercalcemia, and metabolic alkalosis, which can lead to cardiac arrhythmias or hypotension. Rarely, anaphylactic reactions may occur. Continuous monitoring of electrolyte levels and patient vitals is essential.

Multibic should be avoided in patients with known hypersensitivity to any of its components, in those with uncontrolled hyperkalemia, severe hypernatremia, or in individuals where rapid volume expansion could worsen heart failure. Clinical judgment is required for each case.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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