Product image of Multibic (Sodium Hydrogen Carbonate, Magnesium Chloride Hexahydrate, Potassium Chloride, Sodium Chloride, Calc) supplied by GNH India

Multibic

Active Ingredient:
Sodium Hydrogen Carbonate, Magnesium Chloride Hexahydrate, Potassium Chloride, Sodium Chloride, Calc
Origin:
EU

Multibic (Sodium Hydrogen Carbonate, Magnesium Chloride Hexahydrate, Potassium Chloride, Sodium Chloride, Calc)

Sodium hydrogen carbonate, the active ingredient in Multibic, is a dialysis electrolyte solution presented as an intravenous solution for haemodialysis use. It provides sodium, potassium, magnesium, calcium and chloride ions together with a bicarbonate buffer to correct electrolyte and acid‑base disturbances in patients undergoing renal replacement therapy.

GNH India supplies Multibic as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres and dialysis clinics worldwide.

Manufacturer / TM Owner

Fresenius Medical Care Deutschland Gmbh

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Indications & Clinical Uses

Multibic is employed in renal replacement therapy to manage electrolyte and acid‑base balance during haemodialysis.

  • Haemodialysis: provides balanced electrolytes and bicarbonate to maintain physiological homeostasis during the procedure.
  • Acute kidney injury requiring dialysis: supplies essential ions to support renal function replacement.
  • Chronic renal failure on maintenance dialysis: helps correct chronic electrolyte deficits and prevent metabolic acidosis.

How It Works

  • Multibic delivers sodium, potassium, magnesium, calcium, chloride and bicarbonate ions directly into the dialysate circuit. The supplied ions replace those lost during ultrafiltration, while the bicarbonate buffer neutralises excess hydrogen ions, thereby correcting metabolic acidosis and stabilising plasma electrolyte concentrations throughout haemodialysis.

Side Effects

Multibic may be associated with a range of adverse reactions, most of which are related to its electrolyte composition and infusion characteristics.

Common Side Effects

  • Mild hypotension: transient drop in blood pressure during infusion.
  • Nausea or vomiting: gastrointestinal discomfort reported in some patients.
  • Headache: mild to moderate headache during or after treatment.
  • Muscle cramps: occasional cramping due to rapid electrolyte shifts.

Serious or Rare Side Effects

  • Severe hyperkalemia: dangerous rise in serum potassium levels.
  • Cardiac arrhythmia: irregular heart rhythm linked to electrolyte imbalance.
  • Anaphylactic reaction: rare but potentially life‑threatening hypersensitivity.

Precautions & Warnings

When using Multibic, clinicians should observe several precautionary measures to ensure patient safety.

  • Electrolyte monitoring: check serum sodium, potassium, calcium and magnesium before and after infusion.
  • Fluid balance assessment: avoid overload in patients with limited cardiac reserve.
  • Cardiac disease caution: use slowly in patients with known arrhythmias or ischemic heart disease.
  • Infusion rate control: do not exceed recommended flow rates to prevent rapid shifts.
  • Compatibility check: ensure solution is compatible with other intravenous fluids.
  • Store at ambient temperature: keep in original packaging, protect from light and moisture, do not freeze.

Avoid Interactions

Multibic can interact with other agents that influence electrolyte levels or fluid balance.

Major Interactions (Avoid)

  • High‑potassium supplements: may cause severe hyperkalemia.
  • Calcium‑containing IV solutions: risk of hypercalcemia.
  • Additional sodium bicarbonate: can precipitate metabolic alkalosis.

Moderate Interactions (Monitor Closely)

  • Loop diuretics: may alter sodium and potassium balance.
  • ACE inhibitors or ARBs: increase risk of hyperkalemia.
  • Beta‑blockers: may enhance hypotensive effects during rapid infusion.

Frequently Asked Questions

Multibic is an intravenous dialysis electrolyte solution used during haemodialysis to replace sodium, potassium, magnesium, calcium and chloride ions and to provide a bicarbonate buffer. It helps maintain electrolyte balance and correct metabolic acidosis in patients receiving renal replacement therapy.

Sodium hydrogen carbonate supplies bicarbonate ions that neutralise excess hydrogen ions in the blood, thereby correcting metabolic acidosis. Together with other electrolytes, it restores the plasma’s ionic composition, supporting normal cellular function during the haemodialysis process.

The prescribed volume and composition of Multibic are individualized. The treating physician determines the appropriate dose based on the patient’s laboratory values, dialysis prescription and clinical condition. No fixed regimen can be stated without a prescriber’s order.

Safety data for Multibic in pregnancy and lactation are limited. It should only be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant, and the decision must be made by the treating obstetrician or nephrologist.

To order Multibic, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and the necessary import documentation.

Multibic offers a balanced combination of sodium, potassium, magnesium, calcium, chloride and bicarbonate, whereas some standard dialysis fluids may lack one or more of these ions or use acetate as a buffer. This broader electrolyte profile can reduce the need for supplemental additives and may improve acid‑base control during treatment.

Store Multibic at ambient temperature, preferably below 25 °C, in its original sealed container. Protect the solution from direct sunlight, moisture and freezing. Inspect the bag for leaks or discoloration before use, and handle it using aseptic technique to maintain sterility.

Multibic is administered intravenously as part of the dialysate circuit during haemodialysis. The solution is connected to the dialysis machine and infused at a rate prescribed by the clinician, ensuring that the electrolyte composition matches the patient’s therapeutic needs.

The most serious risks include severe electrolyte disturbances such as hyperkalemia, hypercalcemia or metabolic alkalosis, which can lead to cardiac arrhythmias. Anaphylactic reactions, although rare, are also possible and require immediate medical intervention.

Multibic should be avoided in patients with known hypersensitivity to any of its components, uncontrolled severe hyperkalemia, uncontrolled hypertension, or those in whom rapid shifts in fluid or electrolytes could compromise cardiovascular stability. Clinical judgment is essential for each individual case.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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