Product image of Multibic (Sodium Hydrogen Carbonate, Magnesium Chloride Hexahydrate, Potassium Chloride, Sodium Chloride, Calc) supplied by GNH India

Multibic

Active Ingredient:
Sodium Hydrogen Carbonate, Magnesium Chloride Hexahydrate, Potassium Chloride, Sodium Chloride, Calc
Origin:
EU

Multibic (Sodium Hydrogen Carbonate, Magnesium Chloride Hexahydrate, Potassium Chloride, Sodium Chloride, Calc)

Sodium hydrogen carbonate, the active ingredient in Multibic, is an electrolyte component presented as a sterile solution for haemodialysis and intravenous use. It is formulated to assist in maintaining acid‑base balance and electrolyte homeostasis during renal replacement therapy.

GNH India supplies Multibic as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals and transplant centres worldwide.

Manufacturer / TM Owner

Fresenius Medical Care Deutschland Gmbh

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Indications & Clinical Uses

Multibic is used as an electrolyte replacement solution in renal replacement therapies, supporting patients with impaired kidney function.

  • Acute kidney injury: helps correct electrolyte imbalances during haemodialysis.
  • Chronic kidney disease: provides necessary electrolytes during maintenance dialysis sessions.
  • Hyperkalemia during dialysis: assists in potassium regulation to prevent dangerous elevations.

How It Works

  • Multibic delivers a balanced mixture of sodium hydrogen carbonate, magnesium chloride, potassium chloride, sodium chloride and calcium to the intravascular compartment. The solution restores plasma osmolarity, corrects metabolic acidosis, and replenishes essential electrolytes, thereby supporting cellular function and hemodynamic stability during haemodialysis or intravenous infusion.

Side Effects

Multibic may be associated with a range of adverse reactions, most of which are related to its electrolyte composition and infusion rate.

Common Side Effects

  • Hypotension: drop in blood pressure during rapid infusion.
  • Nausea: mild gastrointestinal discomfort.
  • Muscle cramps: due to shifts in calcium or magnesium levels.
  • Headache: transient during treatment.
  • Local irritation: at the infusion site.

Serious or Rare Side Effects

  • Electrolyte disturbances (e.g., hypernatremia, hyperkalemia): may require urgent correction.
  • Metabolic alkalosis: excessive bicarbonate load.
  • Anaphylactic reaction: rare hypersensitivity to solution components.
  • Cardiac arrhythmia: secondary to electrolyte imbalance.
  • Pulmonary edema: from fluid overload in susceptible patients.

Precautions & Warnings

When using Multibic, clinicians should observe several safety measures to minimize risks.

  • Assess baseline electrolyte levels: verify serum sodium, potassium, magnesium, and calcium before infusion.
  • Monitor blood pressure: watch for hypotension, especially with rapid administration.
  • Adjust composition for cardiac disease: tailor electrolyte concentrations in patients with heart failure.
  • Avoid in severe hypernatremia: high sodium load may exacerbate condition.
  • Use caution in pregnancy: limited data, weigh benefits against potential fetal exposure.
  • Store at ambient temperature: keep in original container, protect from light and moisture.

Avoid Interactions

Multibic can interact with other medications that affect electrolyte balance or cardiovascular function.

Major Interactions (Avoid)

  • High‑dose potassium supplements: risk of dangerous hyperkalemia.
  • Calcium‑containing IV solutions: potential calcium overload.

Moderate Interactions (Monitor Closely)

  • Loop diuretics: may amplify electrolyte shifts.
  • ACE inhibitors: can increase serum potassium.
  • Beta‑blockers: may mask hypotensive responses during infusion.

Frequently Asked Questions

Multibic is an intravenous electrolyte solution used during haemodialysis and other renal replacement therapies to restore electrolyte balance, correct acid‑base disturbances, and support hemodynamic stability in patients with acute or chronic kidney failure.

Sodium hydrogen carbonate acts as a bicarbonate source, helping to neutralize metabolic acidosis by buffering excess hydrogen ions in the blood. This contributes to maintaining the normal pH range during dialysis sessions.

The dose of Multibic is individualized by the prescribing clinician based on the patient’s electrolyte profile, fluid status, and the specific dialysis protocol. Dosage decisions are made by qualified healthcare professionals.

Safety data for Multibic in pregnancy and lactation are limited. Use is only recommended if the potential benefit to the mother outweighs any possible risk to the fetus or infant, and should be decided by the treating physician.

To order Multibic, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Multibic offers a balanced electrolyte composition that includes sodium hydrogen carbonate, magnesium chloride, potassium chloride, sodium chloride and calcium, similar to standard dialysate solutions. Its formulation is designed for precise electrolyte management, and differences among products usually relate to individual ion concentrations and buffering capacity.

Multibic should be stored at ambient temperature, below 25 °C, in its original sealed container. Protect the solution from direct sunlight, moisture, and extreme temperature fluctuations to maintain its sterility and efficacy.

Multibic is administered intravenously, typically as part of the dialysis circuit or via a controlled infusion pump. The infusion rate and total volume are set by the dialysis machine or clinician according to the patient’s treatment plan.

Serious risks include electrolyte disturbances such as hypernatremia, hyperkalemia, or metabolic alkalosis, which can lead to cardiac arrhythmias or neurological symptoms. Anaphylactic reactions, though rare, also represent a critical safety concern.

Multibic should be avoided in patients with known hypersensitivity to any of its components, severe hypernatremia, uncontrolled cardiac arrhythmias, or in those where the electrolyte composition is contraindicated without appropriate medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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