Product image of Multibic (Sodium Hydrogen Carbonate, Magnesium Chloride Hexahydrate, Potassium Chloride, Sodium Chloride, Calc) supplied by GNH India

Multibic

Active Ingredient:
Sodium Hydrogen Carbonate, Magnesium Chloride Hexahydrate, Potassium Chloride, Sodium Chloride, Calc
Origin:
EU

Multibic (Sodium Hydrogen Carbonate, Magnesium Chloride Hexahydrate, Potassium Chloride, Sodium Chloride, Calc)

Sodium Hydrogen Carbonate, Magnesium Chloride Hexahydrate, Potassium Chloride, Sodium Chloride and Calcium, the active ingredients in Multibic, are an electrolyte solution presented as a solution for injection for intravenous and haemodialysis use. It is employed to correct acid‑base and electrolyte imbalances in patients undergoing renal replacement therapy.

GNH India supplies Multibic as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres and dialysis clinics worldwide. The company adheres to EU GMP standards and provides regulatory documentation for global distribution.

Manufacturer / TM Owner

Fresenius Medical Care Deutschland Gmbh

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Indications & Clinical Uses

Multibic is used in renal replacement therapy to manage electrolyte and acid‑base disturbances.

  • Hemodialysis: restores electrolyte balance and buffering capacity during treatment.
  • Chronic renal failure: provides necessary ions to compensate for reduced kidney function.
  • Acute electrolyte replacement: corrects sudden deficits of sodium, potassium, magnesium, calcium and bicarbonate.

How It Works

  • Multibic delivers a balanced mixture of sodium, potassium, calcium, magnesium and bicarbonate ions directly into the bloodstream. The solution supplies essential electrolytes and buffering capacity, helping to normalize plasma pH and maintain osmotic equilibrium. By matching the composition of normal plasma, it supports cellular function and facilitates removal of metabolic waste during haemodialysis.

Side Effects

Multibic may be associated with infusion‑related reactions and electrolyte shifts.

Common Side Effects

  • Mild hypotension: transient drop in blood pressure during infusion.
  • Nausea: occasional feeling of queasiness.
  • Vomiting: rare, usually mild.
  • Headache: transient discomfort.
  • Muscle cramps: mild, self‑limiting.
  • Low‑grade fever: mild temperature rise.

Serious or Rare Side Effects

  • Hyperkalemia: dangerous elevation of serum potassium.
  • Severe hypertension: marked increase in blood pressure.
  • Metabolic alkalosis: excessive bicarbonate leading to high pH.
  • Anaphylactic reaction: severe allergic response.
  • Cardiac arrhythmia: irregular heart rhythm due to electrolyte imbalance.
  • Severe electrolyte imbalance: life‑threatening disturbances of sodium, calcium or magnesium.

Precautions & Warnings

When using Multibic, clinicians should observe several safety measures.

  • Dose adjustment: tailor electrolyte composition to individual patient laboratory results.
  • Monitoring: check serum electrolytes and acid‑base status before and after infusion.
  • Contraindications: avoid in patients with known hypersensitivity to any component.
  • Fluid overload: assess volume status to prevent pulmonary edema.
  • Use in pregnancy: limited data; weigh potential benefits against unknown risks.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze.

Avoid Interactions

Multibic can interact with other medicines that affect electrolyte balance.

Major Interactions (Avoid)

  • Calcium channel blockers: may potentiate calcium load leading to hypercalcemia.
  • Potassium‑sparing diuretics: increase risk of hyperkalemia.
  • ACE inhibitors/ARBs: can exacerbate potassium accumulation.
  • Additional sodium bicarbonate solutions: additive sodium load causing hypertension.
  • Blood transfusions: may alter electrolyte balance.

Moderate Interactions (Monitor Closely)

  • Loop diuretics: may require electrolyte adjustments.
  • Insulin therapy: shifts potassium intracellularly, monitor levels.
  • Anticoagulants used in dialysis: monitor for bleeding if volume shifts occur.
  • Beta‑agonists: can cause transient potassium shifts.
  • Magnesium‑containing laxatives: additive magnesium load.

Frequently Asked Questions

Multibic is an intravenous electrolyte solution used during haemodialysis and other renal replacement therapies. It supplies sodium, potassium, calcium, magnesium and bicarbonate to correct acid‑base disturbances and replenish electrolytes in patients with renal failure or acute electrolyte loss.

The blend provides ions that mimic normal plasma composition. Sodium and chloride help maintain extracellular fluid volume, potassium supports cardiac and muscular function, magnesium and calcium are essential for enzymatic reactions, and bicarbonate offers buffering capacity to stabilize blood pH during dialysis.

The prescribed dose of Multibic is individualized. The treating physician determines the volume and concentration based on the patient’s laboratory values, dialysis prescription and clinical status. No fixed dosing regimen is provided in the product information.

Safety data for Multibic in pregnant or lactating women are limited. Use is only recommended when the potential benefit to the mother outweighs any possible risk to the fetus or infant, and the decision should be made by the prescribing clinician.

To order Multibic, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where required) and necessary import documentation.

Multibic contains a balanced mix of sodium, potassium, calcium, magnesium and bicarbonate, similar to many commercial dialysis fluids. Its specific composition may differ in the concentration of each ion, offering flexibility for clinicians to tailor therapy. Compared with generic solutions, Multibic adheres to EU quality standards and provides full regulatory documentation.

Multibic should be stored at 2‑8 °C in a refrigerator. Keep the container in its original packaging, protect it from light, and avoid freezing or shaking the solution. Inspect the product for any particulate matter or discoloration before use.

Multibic is administered intravenously, typically as part of the dialysate circuit during haemodialysis. It can also be given as a direct intravenous infusion when electrolyte replacement is required. Administration should be performed by qualified healthcare personnel following aseptic technique and the prescribed infusion rate.

Serious risks include hyperkalemia, severe hypertension, metabolic alkalosis, anaphylactic reactions and life‑threatening electrolyte imbalances that can lead to cardiac arrhythmias. Continuous monitoring of serum electrolytes and vital signs during and after infusion is essential to detect these complications early.

Multibic should be avoided in patients with known hypersensitivity to any of its components, uncontrolled severe hypertension, existing hyperkalemia or severe electrolyte disturbances that could be worsened by the solution. Clinicians should also exercise caution in patients with severe fluid overload or unstable cardiac conditions.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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