Product image of Multibic (Sodium Hydrogen Carbonate, Magnesium Chloride Hexahydrate, Potassium Chloride, Sodium Chloride, Calc) supplied by GNH India

Multibic

Active Ingredient:
Sodium Hydrogen Carbonate, Magnesium Chloride Hexahydrate, Potassium Chloride, Sodium Chloride, Calc
Origin:
EU

Multibic (Sodium Hydrogen Carbonate, Magnesium Chloride Hexahydrate, Potassium Chloride, Sodium Chloride, Calc)

Sodium hydrogen carbonate, the active ingredient in Multibic, is an electrolyte component presented as an intravenous solution for haemodialysis use. It helps correct acid‑base disturbances and electrolyte imbalances during renal replacement therapy.
GNH India supplies Multibic as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Fresenius Medical Care Deutschland Gmbh

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Indications & Clinical Uses

Multibic is used as an intravenous electrolyte solution to manage disturbances that arise during renal replacement therapies.

  • Acute metabolic acidosis in dialysis patients: restores bicarbonate levels and normalises pH.
  • Electrolyte imbalance correction during haemodialysis: supplies sodium, potassium, magnesium and calcium to maintain plasma homeostasis.
  • Prevention of hypokalaemia in renal therapy: provides controlled potassium to avoid low serum potassium during treatment.

How It Works

  • Multibic delivers a balanced mix of bicarbonate, sodium, potassium, magnesium and calcium ions directly into the bloodstream. The bicarbonate component buffers excess hydrogen ions, correcting metabolic acidosis, while the accompanying electrolytes replenish those lost during haemodialysis, supporting cellular function, nerve conduction and cardiac stability.

Side Effects

Multibic may be associated with a range of infusion‑related reactions.

Common Side Effects

  • Hypotension: transient drop in blood pressure during infusion.
  • Nausea: mild gastrointestinal discomfort.
  • Mild fever: low‑grade temperature rise.
  • Local infusion site irritation: redness or pain at the catheter site.

Serious or Rare Side Effects

  • Severe hyperkalaemia: dangerously high potassium levels.
  • Cardiac arrhythmia: irregular heart rhythm linked to electrolyte shifts.
  • Metabolic alkalosis: excessive bicarbonate leading to high pH.
  • Anaphylactic reaction: rare severe allergic response requiring immediate medical attention.

Precautions & Warnings

When using Multibic, clinicians should observe several safety measures.

  • Renal function monitoring: check serum electrolytes regularly to avoid overload.
  • Cardiac status assessment: watch for arrhythmias, especially in patients with existing heart disease.
  • Fluid balance management: ensure total volume does not exceed patient’s tolerance.
  • Pregnancy considerations: limited data; use only if the potential benefit outweighs risk.
  • Store below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Multibic can interact with other medications that affect electrolyte balance.

Major Interactions (Avoid)

  • Potassium‑sparing diuretics: risk of severe hyperkalaemia.
  • High‑dose calcium supplements: may cause hypercalcaemia.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors: monitor potassium levels.
  • Beta‑blockers: observe blood pressure changes.
  • Concurrent IV electrolyte solutions: avoid duplication of ions.

Frequently Asked Questions

Multibic is an intravenous electrolyte solution used during haemodialysis and other renal replacement therapies to correct metabolic acidosis and replenish key electrolytes such as sodium, potassium, magnesium and calcium.

Sodium hydrogen carbonate provides bicarbonate ions that buffer excess hydrogen ions, raising blood pH toward normal. The accompanying electrolytes replace those lost during dialysis, supporting cellular function and cardiac stability.

The dose of Multibic is determined by the prescribing clinician based on the patient’s laboratory values, dialysis prescription and overall fluid balance. Exact volume and rate are individualized for each treatment.

Safety data for Multibic in pregnancy and lactation are limited. It should only be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant, and under close medical supervision.

To order Multibic, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Multibic combines bicarbonate with a balanced mix of sodium, potassium, magnesium and calcium, offering a comprehensive electrolyte profile in a single IV bag. Compared with solutions that provide only one or two ions, Multibic reduces the need for multiple infusions and simplifies electrolyte management during dialysis.

Multibic should be stored below 25 °C, in its original packaging, and protected from moisture. It does not require refrigeration, but the container must be kept upright and inspected for any damage before use.

Multibic is administered intravenously, typically as part of the dialysis circuit or via a dedicated infusion line. The infusion rate is set by the dialysis machine or infusion pump according to the clinician’s prescription.

Serious risks include severe hyperkalaemia, cardiac arrhythmias, metabolic alkalosis and rare anaphylactic reactions. Continuous monitoring of electrolytes, cardiac rhythm and patient vitals is essential during administration.

Multibic should be avoided in patients with known hypersensitivity to any of its components, uncontrolled hyperkalaemia, severe hypercalcaemia, or those for whom the electrolyte composition would exacerbate existing metabolic disturbances.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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