Product image of Multibic (Sodium Hydrogen Carbonate, Magnesium Chloride Hexahydrate, Potassium Chloride, Sodium Chloride, Calc) supplied by GNH India

Multibic

Active Ingredient:
Sodium Hydrogen Carbonate, Magnesium Chloride Hexahydrate, Potassium Chloride, Sodium Chloride, Calc
Origin:
EU

Multibic (Sodium Hydrogen Carbonate, Magnesium Chloride Hexahydrate, Potassium Chloride, Sodium Chloride, Calc)

Multibic, the active ingredient in Multibic, is a electrolyte solution presented as N/A/solution for injection for intravenous and haemodialysis use. It provides balanced electrolytes and buffering capacity to support patients requiring fluid and electrolyte management during renal replacement therapy.

GNH India supplies Multibic as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide. The company follows EU GMP standards and offers reliable logistics for global healthcare facilities.

Manufacturer / TM Owner

Fresenius Medical Care Deutschland Gmbh

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Indications & Clinical Uses

Multibic is used to manage electrolyte balance and acid‑base status in patients undergoing renal replacement therapy or requiring intravenous electrolyte supplementation.

  • Acute renal failure: helps maintain electrolyte homeostasis during haemodialysis.
  • Chronic kidney disease: supports ongoing electrolyte replacement in dialysis patients.
  • Metabolic acidosis: provides bicarbonate buffering to correct acid‑base disturbances.
  • Perioperative fluid management: supplies essential electrolytes during surgery when large fluid shifts occur.

How It Works

  • Multibic delivers a balanced mixture of sodium hydrogen carbonate, magnesium chloride, potassium chloride, sodium chloride and calcium ions. Upon intravenous infusion, these ions disperse into the extracellular fluid, restoring plasma electrolyte concentrations, correcting acid‑base imbalances through bicarbonate buffering, and contributing to osmotic equilibrium. The formulation is designed to complement the patient’s endogenous electrolyte pools and support renal replacement procedures.

Side Effects

Multibic, like other intravenous electrolyte solutions, may be associated with adverse reactions.

Common Side Effects

  • Injection site pain or irritation.
  • Mild hypernatremia.
  • Mild hyperkalemia.
  • Transient hypotension.
  • Nausea.
  • Headache.

Serious or Rare Side Effects

  • Severe hyperkalemia leading to cardiac arrhythmia.
  • Severe hypernatremia causing neurological symptoms.
  • Fluid overload with pulmonary edema.
  • Allergic reactions including anaphylaxis.
  • Metabolic alkalosis.
  • Significant electrolyte imbalance requiring medical intervention.

Precautions & Warnings

When using Multibic, clinicians should observe the following precautions to ensure patient safety.

  • Baseline assessment: evaluate electrolyte levels before administration.
  • Volume status: monitor fluid balance to avoid overload.
  • Cardiac monitoring: watch for arrhythmias in patients with electrolyte disturbances.
  • Renal function: adjust infusion rate based on kidney performance.
  • Compatibility: verify compatibility with other IV medications before co‑administration.
  • Store at ambient temperature: keep in original container, protect from light and moisture.

Avoid Interactions

Multibic can interact with other medicines; awareness of these interactions helps prevent complications.

Major Interactions (Avoid)

  • Concurrent use of potassium‑sparing diuretics may cause dangerous hyperkalemia.
  • High‑dose sodium bicarbonate solutions can lead to severe metabolic alkalosis.
  • Calcium‑containing medications may precipitate when mixed, risking emboli.

Moderate Interactions (Monitor Closely)

  • Loop diuretics may increase electrolyte loss, requiring dose adjustment.
  • ACE inhibitors or ARBs can affect potassium levels; monitor electrolytes.
  • Blood transfusions may alter calcium and magnesium balance; observe closely.

Frequently Asked Questions

Multibic is an intravenous electrolyte solution used to restore and maintain normal plasma electrolyte concentrations and acid‑base balance in patients undergoing haemodialysis, those with acute or chronic kidney impairment, and individuals who need rapid intravenous electrolyte supplementation.

The solution contains sodium hydrogen carbonate, magnesium chloride, potassium chloride, sodium chloride and calcium ions. When infused, these ions disperse into the extracellular fluid, correcting deficits, providing bicarbonate buffering for metabolic acidosis, and supporting osmotic equilibrium essential for renal replacement and fluid‑management therapies.

The dose of Multibic is determined by the prescribing clinician based on the patient’s electrolyte profile, fluid status, and the specific clinical situation. Dosage may be adjusted during haemodialysis sessions or other intravenous therapy, and should follow the healthcare professional’s instructions.

Safety data for Multibic in pregnancy and lactation are limited. Use is only recommended if the potential benefit to the mother outweighs any possible risk to the fetus or infant, and the decision should be made by a qualified healthcare provider.

To order Multibic, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if required) and necessary import documentation.

Multibic offers a balanced combination of sodium, potassium, calcium, magnesium and bicarbonate, making it suitable for both electrolyte replacement and acid‑base correction. Compared with single‑ion solutions, it reduces the need for multiple infusions and helps streamline fluid management during dialysis or critical‑care settings.

Multibic should be stored at ambient temperature, below 25 °C, in its original packaging. Protect the solution from direct sunlight, moisture and extreme temperature fluctuations. Inspect the container for any signs of damage before use and discard if the solution appears discolored or particulate.

Multibic is administered intravenously, either as a continuous infusion during haemodialysis or as a bolus injection when rapid electrolyte correction is needed. Administration should be performed by trained healthcare personnel using aseptic technique and appropriate infusion equipment.

Serious risks include severe hyperkalemia or hypernatremia, fluid overload leading to pulmonary edema, metabolic alkalosis, and rare allergic reactions such as anaphylaxis. Continuous monitoring of electrolyte levels, cardiac rhythm and fluid balance is essential to detect and manage these complications promptly.

Multibic should be avoided in patients with known hypersensitivity to any of its components, uncontrolled severe hyperkalemia or hypernatremia, and in those where fluid overload is a contraindication. Clinicians should also exercise caution in patients with severe cardiac arrhythmias or uncompensated metabolic disorders.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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