Product image of Multibic (Sodium Hydrogen Carbonate, Magnesium Chloride Hexahydrate, Sodium Chloride, Calcium Chloride Dihydra) supplied by GNH India

Multibic

Active Ingredient:
Sodium Hydrogen Carbonate, Magnesium Chloride Hexahydrate, Sodium Chloride, Calcium Chloride Dihydra
Origin:
EU

Multibic (Sodium Hydrogen Carbonate, Magnesium Chloride Hexahydrate, Sodium Chloride, Calcium Chloride Dihydra)

Sodium hydrogen carbonate, magnesium chloride hexahydrate, sodium chloride and calcium chloride dihydrate, the active ingredients in Multibic, are an electrolyte solution presented as an intravenous solution for haemodialysis and intravenous use. It provides essential electrolytes and bicarbonate to support patients undergoing renal replacement therapy.

GNH India supplies Multibic as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Fresenius Medical Care Deutschland Gmbh

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Indications & Clinical Uses

Multibic is an electrolyte solution used in renal replacement therapy and intravenous electrolyte management.

  • Haemodialysis: maintains electrolyte balance and acid‑base status during dialysis sessions.
  • Intravenous electrolyte replacement: corrects deficits of sodium, chloride, calcium, magnesium and bicarbonate in patients with renal failure or peri‑operative fluid loss.
  • Renal replacement therapy adjunct: supports acid‑base control in patients receiving continuous renal replacement therapies.

How It Works

  • Multibic delivers sodium, chloride, calcium, magnesium and bicarbonate ions directly into the bloodstream. The supplied ions replace those lost during haemodialysis or fluid shifts, helping to preserve plasma electrolyte concentrations and to buffer hydrogen ions, thereby stabilising acid‑base balance and preventing metabolic acidosis.

Side Effects

Multibic may be associated with a range of adverse reactions, most of which are mild and transient.

Common Side Effects

  • Nausea or vomiting
  • Mild hypotension during infusion
  • Headache
  • Transient hypernatremia
  • Mild hypercalcemia
  • Mild metabolic alkalosis

Serious or Rare Side Effects

  • Severe hypermagnesemia leading to cardiac arrhythmia
  • Severe hypercalcemia with neuromuscular irritability
  • Anaphylactic reaction
  • Significant fluid overload causing pulmonary edema
  • Severe metabolic alkalosis requiring intervention
  • Life‑threatening hypotension

Precautions & Warnings

When using Multibic, clinicians should observe standard safety measures for intravenous electrolyte solutions.

  • Monitor electrolytes: check serum sodium, calcium, magnesium and bicarbonate levels regularly.
  • Adjust infusion rate: titrate based on patient tolerance and laboratory results.
  • Cardiac caution: use carefully in patients with pre‑existing cardiac disease or arrhythmias.
  • Hypernatremia avoidance: avoid in patients with markedly elevated serum sodium.
  • Pregnancy and lactation: use only if clearly indicated, as safety data are limited.
  • Store at ambient temperature: keep in original container, protect from moisture and direct sunlight.

Avoid Interactions

Multibic can interact with other agents that affect electrolyte balance or acid‑base status.

Major Interactions (Avoid)

  • Concurrent calcium‑containing solutions: may cause dangerous hypercalcemia.
  • Additional bicarbonate preparations: risk of severe metabolic alkalosis.
  • High‑dose potassium supplements: can precipitate hyperkalemia when combined with sodium load.

Moderate Interactions (Monitor Closely)

  • Loop diuretics: may enhance electrolyte shifts, requiring closer monitoring.
  • ACE inhibitors or ARBs: can alter sodium and potassium handling.
  • NSAIDs: may affect renal perfusion and electrolyte excretion.
  • Blood transfusions: potential for citrate‑related calcium binding.
  • Antacids containing magnesium or calcium: may contribute to cumulative electrolyte load.

Frequently Asked Questions

Multibic is an intravenous electrolyte solution employed during haemodialysis and as a supplement for intravenous electrolyte replacement. It helps maintain plasma concentrations of sodium, chloride, calcium, magnesium and bicarbonate, supporting acid‑base balance in patients undergoing renal replacement therapy or experiencing significant fluid and electrolyte losses.

The active ingredients—sodium hydrogen carbonate, magnesium chloride, sodium chloride and calcium chloride—provide essential ions directly into the bloodstream. These ions replace those removed during dialysis or lost in clinical situations, buffering hydrogen ions to correct acidosis and stabilising electrolyte concentrations critical for cardiac, neuromuscular and renal function.

The dose of Multibic is individualized by the prescribing clinician based on the patient’s electrolyte profile, dialysis prescription and clinical condition. Healthcare professionals determine the infusion volume, rate and duration to achieve the desired electrolyte and acid‑base targets.

Safety data for Multibic in pregnancy and lactation are limited. It should only be used when clearly indicated and after a risk‑benefit assessment by the treating physician. The prescriber must consider the potential impact on maternal and fetal electrolyte balance before initiating therapy.

To order Multibic, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and the necessary import documentation.

Multibic offers a balanced combination of sodium, chloride, calcium, magnesium and bicarbonate, similar to many commercial dialysis fluids. Its formulation is designed to provide comprehensive electrolyte replacement in a single solution, potentially reducing the need for multiple adjunctive infusions compared with fluids that lack one or more of these ions.

Multibic should be stored at ambient temperature, below 25 °C, in its original packaging. Protect the solution from moisture, direct sunlight and extreme temperature fluctuations. Ensure the container is sealed when not in use to maintain sterility.

Multibic is administered intravenously, either as a component of the dialysis circuit during haemodialysis or as a separate IV infusion for electrolyte replacement. The infusion rate and volume are set by the clinician according to the patient’s laboratory results and clinical needs.

Serious risks include severe hypermagnesemia, hypercalcemia, profound metabolic alkalosis, anaphylactic reactions and significant fluid overload leading to pulmonary edema. Continuous monitoring of electrolytes, acid‑base status and fluid balance is essential to detect and manage these complications promptly.

Multibic is contraindicated in patients with known hypersensitivity to any of its components. It should be used with caution, or avoided, in individuals with severe hypernatremia, uncontrolled hypercalcemia, severe cardiac arrhythmias, or those for whom fluid overload would pose a high risk.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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