Product image of Multibic (Sodium Hydrogen Carbonate, Magnesium Chloride Hexahydrate, Sodium Chloride, Calcium Chloride Dihydra) supplied by GNH India

Multibic

Active Ingredient:
Sodium Hydrogen Carbonate, Magnesium Chloride Hexahydrate, Sodium Chloride, Calcium Chloride Dihydra
Origin:
EU

Multibic (Sodium Hydrogen Carbonate, Magnesium Chloride Hexahydrate, Sodium Chloride, Calcium Chloride Dihydra)

Sodium hydrogen carbonate, magnesium chloride hexahydrate, sodium chloride and calcium chloride dihydrate, the active ingredients in Multibic, are an electrolyte solution presented as an intravenous solution for haemodialysis and renal replacement therapy use. It provides essential ions to support electrolyte balance and acid‑base status in patients undergoing dialysis.

GNH India supplies Multibic as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres and dialysis clinics worldwide.

Manufacturer / TM Owner

Fresenius Medical Care Deutschland Gmbh

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Indications & Clinical Uses

Multibic is employed in renal replacement therapy and dialysis to correct electrolyte and acid‑base disturbances.

  • Hemodialysis: maintains electrolyte and acid‑base balance during treatment.
  • Renal replacement therapy: supplies sodium, chloride, calcium, magnesium and bicarbonate to patients with renal failure.
  • Electrolyte replacement: corrects deficits of key ions during intravenous administration.

How It Works

  • Multibic delivers sodium, chloride, calcium, magnesium and bicarbonate ions directly into the bloodstream. The supplied bicarbonate acts as a buffer to counter metabolic acidosis, while the cations restore extracellular electrolyte concentrations. By matching the ionic composition required during haemodialysis, the solution helps preserve physiological pH and osmolarity, supporting normal cellular function in patients with impaired renal clearance.

Side Effects

Multibic may be associated with a range of infusion‑related reactions.

Common Side Effects

  • Mild hypernatremia: slight elevation of serum sodium.
  • Mild hypercalcemia: modest increase in calcium levels.
  • Infusion site irritation: redness or discomfort at the catheter site.

Serious or Rare Side Effects

  • Severe hypermagnesemia: dangerous rise in magnesium concentration.
  • Anaphylactic reaction: acute allergic response requiring immediate treatment.
  • Cardiac arrhythmia: irregular heart rhythm linked to electrolyte imbalance.

Precautions & Warnings

When using Multibic, clinicians should observe several safety measures.

  • Monitor serum electrolytes: regularly check sodium, calcium, magnesium and bicarbonate levels.
  • Adjust infusion rate: tailor to the patient’s fluid balance and dialysis prescription.
  • Use caution in heart failure: excess sodium may worsen fluid overload.
  • Avoid in severe hypercalcemia or hypermagnesemia: risk of exacerbating electrolyte excess.
  • Store at ambient temperature: keep in original container, protect from light and moisture.

Avoid Interactions

Multibic can interact with other agents that affect electrolyte balance.

Major Interactions (Avoid)

  • Calcium‑containing antacids: may cause hypercalcemia.
  • High‑dose magnesium supplements: increase risk of hypermagnesemia.
  • Concurrent sodium bicarbonate infusion: can lead to severe metabolic alkalosis.

Moderate Interactions (Monitor Closely)

  • Loop diuretics: may alter sodium and calcium excretion.
  • ACE inhibitors: affect sodium and potassium handling.
  • NSAIDs: can impair renal function and fluid status.

Frequently Asked Questions

Multibic is an intravenous electrolyte solution used primarily during haemodialysis and other renal replacement therapies to provide sodium, chloride, calcium, magnesium and bicarbonate ions, helping maintain electrolyte balance and correct acid‑base disturbances in patients with kidney failure.

The combination of sodium hydrogen carbonate, magnesium chloride, sodium chloride and calcium chloride delivers essential ions directly into the bloodstream. Bicarbonate buffers excess acid, while the cations restore extracellular electrolyte concentrations, supporting normal cellular function during dialysis.

The prescribed dose of Multibic is determined by the treating physician based on the patient’s individual dialysis prescription, electrolyte status and fluid balance. Dosage is tailored to each clinical situation and is not standardized.

Safety data for Multibic in pregnancy and lactation are limited. It should only be used if the potential benefit to the mother outweighs any possible risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.

To order Multibic, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and import documentation.

Multibic offers a balanced mix of sodium, chloride, calcium, magnesium and bicarbonate, making it suitable for comprehensive electrolyte and acid‑base management during dialysis. Compared with single‑ion solutions, it reduces the need for multiple infusions and simplifies fluid management, though choice of product depends on specific patient needs and institutional protocols.

Multibic should be stored at ambient temperature, preferably below 25 °C, in its original packaging. Protect the solution from direct sunlight, moisture and extreme temperature fluctuations to maintain stability and sterility.

Multibic is administered intravenously, typically as part of the dialysis circuit or via a controlled infusion pump. The rate and volume are adjusted by the dialysis team according to the patient’s prescribed treatment plan and real‑time electrolyte monitoring.

Serious risks include severe hypernatremia, hypercalcemia, hypermagnesemia, metabolic alkalosis, cardiac arrhythmias and anaphylactic reactions. Continuous monitoring of electrolyte levels and patient vitals during infusion helps mitigate these risks.

Multibic is contraindicated in patients with known hypersensitivity to any of its components, as well as those with severe hypercalcemia, hypermagnesemia or uncontrolled metabolic alkalosis. Clinicians should also exercise caution in patients with fluid overload or severe heart failure.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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