Product image of Multibic (Sodium Hydrogen Carbonate, Magnesium Chloride Hexahydrate, Sodium Chloride, Calcium Chloride Dihydra) supplied by GNH India

Multibic

Active Ingredient:
Sodium Hydrogen Carbonate, Magnesium Chloride Hexahydrate, Sodium Chloride, Calcium Chloride Dihydra
Origin:
EU

Multibic (Sodium Hydrogen Carbonate, Magnesium Chloride Hexahydrate, Sodium Chloride, Calcium Chloride Dihydra)

Sodium hydrogen carbonate, the active ingredient in Multibic, is an electrolyte solution presented as a solution for injection for haemodialysis and intravenous use. It treats electrolyte imbalance and supports acid‑base balance during renal replacement therapy in patients requiring dialysis.

GNH India supplies Multibic as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres and dialysis clinics worldwide.

Manufacturer / TM Owner

Fresenius Medical Care Deutschland Gmbh

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Indications & Clinical Uses

Multibic is an electrolyte solution used in renal replacement therapy and related conditions.

  • Haemodialysis: provides essential electrolytes and buffering capacity to maintain acid‑base balance during the procedure.
  • Electrolyte replacement during renal replacement therapy: restores sodium, potassium, calcium, magnesium and chloride to physiologic levels.
  • Intravenous fluid replacement in acute kidney injury: supports volume status and electrolyte homeostasis when kidney function is compromised.

How It Works

  • Multibic delivers sodium hydrogen carbonate, magnesium chloride, sodium chloride and calcium chloride, supplying buffering agents and key electrolytes. The solution helps maintain plasma pH by neutralising excess acids, while the added cations and anions restore electrolyte concentrations, supporting cardiovascular stability and cellular function during haemodialysis or intravenous fluid therapy.

Side Effects

Multibic may cause adverse reactions related to its electrolyte composition and infusion characteristics.

Common Side Effects

  • Mild hypernatremia: transient elevation of serum sodium.
  • Infusion site irritation: redness or discomfort at the catheter site.
  • Transient metabolic alkalosis: mild increase in blood pH.

Serious or Rare Side Effects

  • Severe electrolyte disturbances (e.g., hyperkalemia, profound hypocalcemia) requiring immediate medical intervention.
  • Anaphylactic or severe hypersensitivity reaction.
  • Cardiac arrhythmia secondary to rapid electrolyte shifts.
  • Pulmonary edema in patients with fluid overload.
  • Severe metabolic acidosis if buffering capacity is exceeded.

Precautions & Warnings

When using Multibic, clinicians should observe several safety measures.

  • Baseline assessment: evaluate serum electrolytes and acid‑base status before initiation.
  • Monitoring: regularly check electrolyte levels and blood pH during therapy.
  • Cardiac caution: use with care in patients with known arrhythmias or cardiac disease.
  • Fluid balance: avoid in patients with severe fluid overload or uncontrolled hypertension.
  • Storage: Store at ambient temperature: keep in original container, protect from moisture and direct sunlight.

Avoid Interactions

Multibic can interact with other agents that affect electrolyte balance or fluid status.

Major Interactions (Avoid)

  • Calcium‑containing solutions: risk of precipitation and calcium overload.
  • Potassium supplements: may cause dangerous hyperkalemia.
  • Loop diuretics: can exacerbate electrolyte loss leading to instability.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors or ARBs: may potentiate changes in potassium and sodium.
  • NSAIDs: can affect renal handling of electrolytes.
  • Antacids containing magnesium or aluminum: may alter magnesium levels.
  • Blood transfusions: monitor for shifts in calcium and magnesium during concurrent administration.

Frequently Asked Questions

Multibic is an electrolyte solution indicated for haemodialysis and intravenous electrolyte replacement during renal replacement therapy. It helps maintain acid‑base balance and restores essential electrolytes such as sodium, potassium, calcium, magnesium and chloride in patients with impaired kidney function.

Sodium hydrogen carbonate provides buffering capacity that neutralises excess acids in the blood, helping to stabilise pH. Together with magnesium, calcium and chloride ions, it replenishes key electrolytes, supporting cardiovascular function and cellular processes during dialysis or fluid replacement.

The dose of Multibic is determined by the prescribing clinician based on the patient’s electrolyte profile, fluid requirements and the specifics of the dialysis procedure. Dosing is individualized and should follow institutional protocols and the prescriber’s orders.

Safety data for Multibic in pregnancy and lactation are limited. Use should be considered only if the potential benefit justifies any potential risk to the fetus or infant, and it must be prescribed by a qualified healthcare professional.

To order Multibic, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and import documentation.

Multibic contains a balanced mix of sodium hydrogen carbonate, magnesium chloride, sodium chloride and calcium chloride, offering comprehensive buffering and electrolyte replacement. Compared with standard bicarbonate‑based dialysis solutions, it provides additional magnesium and calcium, which may reduce the need for supplemental electrolytes during treatment.

Multibic should be stored at ambient temperature, below 25 °C, in its original packaging. Protect the solution from moisture, direct sunlight and extreme temperatures. Do not freeze the product, and ensure the container is sealed when not in use.

Multibic is supplied as a sterile solution for injection and is administered intravenously, either as part of the haemodialysis circuit or as a separate IV infusion. Administration should be performed by trained healthcare personnel following aseptic technique and institutional protocols.

Serious risks include severe electrolyte disturbances such as hyperkalemia or profound hypocalcemia, which can lead to cardiac arrhythmias, as well as anaphylactic reactions and pulmonary edema in patients with fluid overload. Immediate medical attention is required if any of these events occur.

Multibic is contraindicated in patients with known hypersensitivity to any of its components, severe hypernatremia, uncontrolled fluid overload, or those receiving incompatible calcium‑containing solutions. Clinicians should also exercise caution in patients with severe cardiac disease or unstable electrolyte levels.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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