Product image of Multibic (Sodium Hydrogen Carbonate, Magnesium Chloride Hexahydrate, Sodium Chloride, Calcium Chloride Dihydra) supplied by GNH India

Multibic

Active Ingredient:
Sodium Hydrogen Carbonate, Magnesium Chloride Hexahydrate, Sodium Chloride, Calcium Chloride Dihydra
Origin:
EU

Multibic (Sodium Hydrogen Carbonate, Magnesium Chloride Hexahydrate, Sodium Chloride, Calcium Chloride Dihydra)

Sodium hydrogen carbonate, magnesium chloride hexahydrate, sodium chloride and calcium chloride dihydrate, the active ingredients in Multibic, are a dialysis solution presented as a solution for injection for haemodialysis and intravenous use. It provides electrolyte and buffering support for patients with renal failure requiring haemodialysis.
GNH India supplies Multibic as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Fresenius Medical Care Deutschland Gmbh

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Indications & Clinical Uses

Multibic is used in renal replacement therapy to manage electrolyte and acid‑base balance during dialysis.

  • Renal failure requiring haemodialysis: supplies essential electrolytes and buffering capacity to maintain plasma stability.
  • Electrolyte replacement during dialysis: restores sodium, chloride, calcium and magnesium levels lost in the procedure.
  • Acid‑base disorders in dialysis: provides bicarbonate to correct metabolic acidosis.

How It Works

  • Multibic delivers sodium hydrogen carbonate, magnesium chloride, sodium chloride and calcium chloride directly into the bloodstream during haemodialysis or intravenous infusion. The solution restores extracellular electrolyte concentrations, contributes to plasma osmolarity, and supplies bicarbonate ions that buffer hydrogen ions, thereby correcting metabolic acidosis and supporting normal cellular function in patients undergoing renal replacement therapy.

Side Effects

Multibic may be associated with a range of adverse reactions, most of which are related to its electrolyte composition and infusion rate.

Common Side Effects

  • Hypotension: drop in blood pressure during infusion.
  • Nausea: mild gastrointestinal discomfort.
  • Vomiting: occasional emesis.
  • Headache: transient cranial pain.
  • Muscle cramps: due to rapid electrolyte shifts.
  • Metallic taste: sensation in the mouth.

Serious or Rare Side Effects

  • Hyperkalemia: elevated serum potassium.
  • Metabolic alkalosis: excessive bicarbonate levels.
  • Cardiac arrhythmia: irregular heart rhythm.
  • Anaphylactic reaction: severe allergic response.
  • Electrolyte imbalance leading to seizures.
  • Hemolysis: destruction of red blood cells.

Precautions & Warnings

When using Multibic, clinicians should observe specific safety measures to minimize risks.

  • Monitor electrolytes: regularly check serum sodium, potassium, calcium and magnesium.
  • Assess fluid status: avoid volume overload in patients with cardiac dysfunction.
  • Adjust dialysis prescription: tailor infusion rates based on individual patient needs.
  • Use cautiously in cardiac disease: watch for arrhythmias and blood pressure changes.
  • Avoid rapid infusion: infuse at recommended rates to prevent sudden shifts.
  • Store at below 25°C: keep in original container, protect from moisture and direct sunlight.

Avoid Interactions

Multibic can interact with other medications that affect electrolyte balance or acid‑base status.

Major Interactions (Avoid)

  • Calcium‑containing antacids: risk of calcium overload.
  • High‑dose potassium supplements: may cause hyperkalemia.
  • Intravenous iron preparations: potential precipitation.
  • Sodium bicarbonate infusion: excess alkalinity.
  • Magnesium sulfate: excessive magnesium levels.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors: altered potassium balance.
  • Loop diuretics: increased electrolyte shifts.
  • Beta‑blockers: possible blood pressure effects.
  • NSAIDs: fluid retention concerns.
  • Anticoagulants used in dialysis: heightened bleeding risk.

Frequently Asked Questions

Multibic is a dialysis solution used as an adjunct in renal replacement therapy. It provides essential electrolytes and buffering capacity during haemodialysis or intravenous fluid replacement, helping to maintain plasma stability in patients with renal failure.

Sodium hydrogen carbonate supplies bicarbonate ions that buffer excess hydrogen ions, correcting metabolic acidosis. Together with magnesium, calcium and sodium chloride, it restores extracellular electrolyte concentrations, supporting normal cellular function during dialysis.

The prescribed dose of Multibic is determined by the treating physician based on the patient’s dialysis prescription, electrolyte status and fluid balance. Dosage is individualized and should follow the clinician’s orders.

The safety of Multibic in pregnancy or lactation has not been established. It should only be used if the potential benefit justifies any potential risk to the mother or infant, and the decision must be made by a qualified healthcare professional.

To order Multibic, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and import documentation.

Multibic contains a balanced mix of sodium hydrogen carbonate, magnesium chloride, sodium chloride and calcium chloride, offering comprehensive electrolyte and buffering support. Compared with standard bicarbonate‑based solutions, it provides additional magnesium and calcium, which may reduce the need for separate supplementation during dialysis.

Multibic should be stored at below 25 °C, in its original packaging, protected from moisture and direct sunlight. Ensure the container is sealed and avoid exposure to extreme temperatures to maintain solution stability.

Multibic is administered as an intravenous solution during haemodialysis or as a direct IV infusion. It is added to the dialysis circuit or infused according to the prescribed rate and volume set by the dialysis team.

Serious risks include hyperkalemia, metabolic alkalosis, cardiac arrhythmias, anaphylactic reactions and severe electrolyte imbalance that can lead to seizures or hemolysis. Continuous monitoring of electrolytes and patient vital signs is essential during administration.

Multibic should be avoided in patients with known hypersensitivity to any of its components, uncontrolled severe electrolyte disturbances, or those for whom rapid shifts in fluid or electrolyte balance could be hazardous, such as certain cardiac or neurologic conditions. Clinical judgment is required.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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