Product image of Multibic (Sodium Hydrogen Carbonate, Magnesium Chloride Hexahydrate, Sodium Chloride, Calcium Chloride Dihydra) supplied by GNH India

Multibic

Active Ingredient:
Sodium Hydrogen Carbonate, Magnesium Chloride Hexahydrate, Sodium Chloride, Calcium Chloride Dihydra
Origin:
EU

Multibic (Sodium Hydrogen Carbonate, Magnesium Chloride Hexahydrate, Sodium Chloride, Calcium Chloride Dihydra)

Sodium Hydrogen Carbonate, the active ingredient in Multibic, is an electrolyte component presented as a sterile solution for intravenous use for haemodialysis and electrolyte management. Combined with magnesium chloride hexahydrate, sodium chloride and calcium chloride dihydrate, the formulation supports acid‑base balance, plasma osmolarity and essential mineral replacement during dialysis sessions.

GNH India supplies Multibic as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres and dialysis clinics worldwide, adhering to EU GMP manufacturing standards. The product is distributed under strict quality‑assurance protocols to ensure safety and efficacy.

Manufacturer / TM Owner

Fresenius Medical Care Deutschland Gmbh

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Indications & Clinical Uses

Multibic is used in haemodialysis to provide electrolyte and acid‑base management.

  • Haemodialysis: restores electrolyte concentrations and plasma osmolarity during the procedure.
  • Metabolic acidosis: supplies bicarbonate to help correct acid‑base disturbances in patients undergoing dialysis.
  • Hypermagnesemia prevention: provides controlled magnesium levels to avoid excess during treatment.

How It Works

  • Multibic delivers sodium, chloride, calcium, magnesium and bicarbonate ions directly into the bloodstream. The bicarbonate acts as a physiological buffer, neutralizing excess hydrogen ions and correcting metabolic acidosis. Sodium and chloride maintain extracellular fluid volume and osmolarity, while calcium and magnesium replenish essential divalent cations lost during dialysis, supporting cardiac and neuromuscular function. The combined electrolyte profile aligns with the composition of plasma, facilitating rapid equilibration during haemodialysis.

Side Effects

Multibic may be associated with infusion‑related reactions and electrolyte disturbances.

Common Side Effects

  • Infusion site irritation: mild pain or redness at the catheter site.
  • Transient hypernatremia: slight increase in serum sodium.
  • Mild metabolic alkalosis: temporary rise in blood pH.
  • Nausea or vomiting: occasional gastrointestinal discomfort.

Serious or Rare Side Effects

  • Severe electrolyte imbalance: marked hypercalcemia, hypermagnesemia or hypokalemia requiring intervention.
  • Anaphylactic reaction: rare hypersensitivity with rash, bronchospasm or hypotension.
  • Cardiac arrhythmia: potentially life‑threatening rhythm disturbances linked to abrupt electrolyte shifts.

Precautions & Warnings

When using Multibic, clinicians should observe the following precautions to ensure patient safety.

  • Electrolyte monitoring: check serum sodium, calcium, magnesium and bicarbonate levels before and after infusion.
  • Fluid overload risk: avoid in patients with severe heart failure or uncontrolled hypertension.
  • Hypercalcemia avoidance: do not administer to patients with known elevated calcium levels.
  • Compatibility check: ensure solution is compatible with other IV fluids and medications to prevent precipitation.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Multibic can interact with certain medications and solutions; careful assessment is required.

Major Interactions (Avoid)

  • Calcium chloride with phosphate binders: may precipitate calcium phosphate, risking embolism.
  • Magnesium chloride with other magnesium salts: can cause dangerous hypermagnesemia.

Moderate Interactions (Monitor Closely)

  • Loop diuretics: increase renal loss of electrolytes, requiring dose adjustment.
  • ACE inhibitors or ARBs: may alter potassium handling, necessitating electrolyte monitoring.
  • NSAIDs: can affect renal function and fluid balance, increasing risk of electrolyte disturbances.

Frequently Asked Questions

Multibic is an intravenous electrolyte solution primarily employed during haemodialysis to maintain acid‑base balance and replace essential minerals such as sodium, calcium, magnesium and bicarbonate that are removed during the procedure.

Sodium Hydrogen Carbonate provides bicarbonate ions, which act as a physiological buffer that neutralizes excess hydrogen ions, helping to correct metabolic acidosis and stabilize blood pH during dialysis.

The prescribed dose of Multibic is determined by the treating physician or dialysis specialist based on the patient’s individual electrolyte profile, treatment duration and clinical condition; no standard dosing is provided here.

Safety of Multibic in pregnancy or lactation has not been established; it should be used only if the potential benefit justifies the potential risk and under close medical supervision.

To order Multibic, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with standard dialysis replacement solutions, Multibic offers a balanced combination of sodium, chloride, calcium, magnesium and bicarbonate, providing comprehensive electrolyte and buffering support in a single sterile IV formulation, which can simplify fluid management during treatment.

Multibic should be stored at 2‑8 °C, kept in its original container, protected from light, and should not be frozen or shaken. Before use, inspect the solution for particulates or discoloration and allow it to reach room temperature if required.

Multibic is administered intravenously, typically as part of the haemodialysis circuit, using a sterile infusion set. The infusion rate and total volume are set by the dialysis machine or clinician according to the patient’s treatment protocol.

The most serious risks include severe electrolyte imbalances such as hypercalcemia or hypermagnesemia, which can lead to cardiac arrhythmias, and rare anaphylactic reactions that require immediate medical intervention.

Multibic should be avoided in patients with known hypersensitivity to any of its components, uncontrolled hypercalcemia, severe fluid overload, or in those for whom the prescribed electrolyte composition is contraindicated.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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