Product image of Multibic (Sodium Hydrogen Carbonate, Magnesium Chloride Hexahydrate, Sodium Chloride, Calcium Chloride Dihydra) supplied by GNH India

Multibic

Active Ingredient:
Sodium Hydrogen Carbonate, Magnesium Chloride Hexahydrate, Sodium Chloride, Calcium Chloride Dihydra
Origin:
EU

Multibic (Sodium Hydrogen Carbonate, Magnesium Chloride Hexahydrate, Sodium Chloride, Calcium Chloride Dihydra)

Sodium Hydrogen Carbonate, the active ingredient in Multibic, is an electrolyte solution presented as a sterile injectable solution for intravenous and haemodialysis use. It helps correct metabolic acidosis and maintain electrolyte balance in patients undergoing renal replacement therapy.

GNH India supplies Multibic as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Fresenius Medical Care Deutschland Gmbh

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Indications & Clinical Uses

Multibic is used as an intravenous electrolyte and buffering solution in renal replacement therapy.

  • Haemodialysis: provides bicarbonate buffering to correct metabolic acidosis during treatment.
  • Peritoneal dialysis: supplies calcium and magnesium to maintain mineral homeostasis.
  • Acute renal failure: assists in stabilising serum electrolytes while renal function recovers.

How It Works

  • Multibic delivers sodium hydrogen carbonate, magnesium chloride, sodium chloride and calcium chloride directly into the bloodstream or dialysis circuit. The bicarbonate component buffers excess hydrogen ions, raising blood pH, while the chloride, calcium and magnesium ions replenish essential electrolytes lost during dialysis, supporting cardiac and neuromuscular function and preventing acid‑base disturbances.

Side Effects

Multibic may be associated with several adverse reactions when administered intravenously.

Common Side Effects

  • Hypotension: transient drop in blood pressure during infusion.
  • Mild nausea or vomiting: related to rapid electrolyte shifts.
  • Local irritation: redness or discomfort at the infusion site.

Serious or Rare Side Effects

  • Hypercalcemia: elevated calcium levels causing cardiac arrhythmia.
  • Severe electrolyte imbalance: marked changes in serum magnesium or chloride leading to neuromuscular symptoms.
  • Anaphylactic reaction: rare hypersensitivity requiring immediate medical intervention.

Precautions & Warnings

When using Multibic, clinicians should observe several safety measures.

  • Monitor electrolytes: check serum calcium, magnesium, sodium and bicarbonate levels before and after infusion.
  • Assess cardiac function: observe ECG for arrhythmias, especially in patients with pre‑existing heart disease.
  • Adjust infusion rate: administer slowly to avoid rapid shifts in plasma osmolality.
  • Contraindications: avoid in patients with known hypersensitivity to any component.
  • Pregnancy and lactation: use only if the potential benefit justifies the risk.
  • Store at ambient temperature: keep below 25°C, protect from moisture and light, and retain in original sealed container.

Avoid Interactions

Multibic can interact with other medications that influence electrolyte or acid‑base status.

Major Interactions (Avoid)

  • Calcium channel blockers: may exacerbate hypercalcemia.
  • Loop diuretics: increase risk of severe electrolyte depletion when combined.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors or ARBs: may potentiate changes in potassium and bicarbonate levels.
  • Antacids containing magnesium or calcium: additive effect on serum concentrations.
  • Sodium‑containing IV fluids: risk of hypernatremia if volumes are not carefully balanced.

Frequently Asked Questions

Multibic is an intravenous electrolyte and buffering solution used primarily during haemodialysis and other renal replacement therapies to correct metabolic acidosis and maintain balanced levels of calcium, magnesium, sodium and chloride in the bloodstream.

Sodium hydrogen carbonate acts as a bicarbonate source that neutralises excess hydrogen ions, raising blood pH. Together with chloride, calcium and magnesium ions, it restores electrolyte homeostasis that can be disrupted during dialysis.

The dose of Multibic is determined by the prescribing clinician based on the patient’s weight, dialysis prescription, and current laboratory values. It is administered intravenously under controlled conditions.

Multibic should be used in pregnancy or while breastfeeding only if the potential therapeutic benefit outweighs any possible risk to the fetus or infant. The decision must be made by a qualified healthcare professional.

To order Multibic, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Multibic contains a balanced combination of bicarbonate, calcium, magnesium and chloride, offering comprehensive electrolyte management. Compared with simpler saline‑based solutions, it provides additional buffering capacity and mineral supplementation, which can reduce the need for separate electrolyte additives.

Multibic should be stored at ambient temperature, below 25 °C, in its original sealed container. Protect it from moisture and direct sunlight to maintain solution stability.

Multibic is administered intravenously, either directly into a peripheral vein or through the dialysis circuit, according to the clinician’s prescribed infusion rate and total volume required for the treatment session.

Serious risks include hypercalcemia, severe electrolyte imbalance and rare anaphylactic reactions. Continuous monitoring of serum electrolytes and cardiac rhythm during infusion helps mitigate these risks.

Patients with known hypersensitivity to any component of Multibic, those with uncontrolled hypercalcemia, or individuals for whom rapid electrolyte shifts are contraindicated should not receive this product.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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