Product image of Multibic (Sodium Hydrogen Carbonate, Magnesium Chloride Hexahydrate, Sodium Chloride, Calcium Chloride Dihydra) supplied by GNH India

Multibic

Active Ingredient:
Sodium Hydrogen Carbonate, Magnesium Chloride Hexahydrate, Sodium Chloride, Calcium Chloride Dihydra
Origin:
EU

Multibic (Sodium Hydrogen Carbonate, Magnesium Chloride Hexahydrate, Sodium Chloride, Calcium Chloride Dihydra)

Sodium hydrogen carbonate, magnesium chloride hexahydrate, sodium chloride, and calcium chloride dihydrate, the active ingredients in Multibic, are electrolytes presented as a solution for injection for intravenous and haemodialysis use. They help maintain electrolyte and acid‑base balance in patients undergoing renal replacement therapy.

GNH India supplies Multibic as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals and dialysis centres worldwide.

Manufacturer / TM Owner

Fresenius Medical Care Deutschland Gmbh

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Indications & Clinical Uses

  • Multibic is an injectable electrolyte solution used in renal replacement and fluid management.
  • Chronic kidney disease undergoing haemodialysis: helps correct electrolyte disturbances and maintain acid‑base balance.
  • Acute renal failure requiring intravenous electrolyte support: provides sodium, chloride, calcium, and magnesium to prevent hypoelectrolytemia.
  • Peri‑operative fluid management in patients at risk of electrolyte loss: supplies essential ions to support cardiovascular stability.

How It Works

  • Multibic delivers sodium, chloride, calcium, and magnesium ions directly into the bloodstream, allowing rapid correction of electrolyte deficits and buffering of metabolic acidosis. The supplied ions participate in physiological processes such as nerve conduction, muscle contraction, and acid‑base regulation, thereby stabilising plasma chemistry during haemodialysis or intravenous therapy.

Side Effects

Multibic may be associated with a range of adverse reactions, most of which are related to its electrolyte composition and the route of administration.

Common Side Effects

  • Injection site pain or erythema.
  • Transient hypotension during rapid infusion.
  • Mild nausea or gastrointestinal discomfort.

Serious or Rare Side Effects

  • Hypercalcemia leading to cardiac arrhythmias.
  • Hypermagnesemia causing muscle weakness or respiratory depression.
  • Severe electrolyte imbalance requiring urgent medical intervention.
  • Anaphylactic or severe hypersensitivity reaction.

Precautions & Warnings

  • When using Multibic, clinicians should observe several safety measures to minimise risks.
  • Assess serum electrolytes before administration: check calcium, magnesium, and sodium levels.
  • Monitor cardiac rhythm during infusion: watch for arrhythmias related to electrolyte shifts.
  • Adjust infusion rate in patients with heart failure: avoid fluid overload.
  • Avoid use in patients with known hypersensitivity to any component.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Multibic can interact with other medicines that affect electrolyte balance or cardiovascular function.

Major Interactions (Avoid)

  • Calcium channel blockers: may exacerbate hypercalcemia.
  • Loop diuretics: increase risk of rapid electrolyte shifts.
  • Anticoagulants used in dialysis circuits: altered clotting when electrolyte composition changes.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors: monitor blood pressure and potassium levels.
  • Beta‑blockers: watch for bradycardia with electrolyte changes.

Frequently Asked Questions

Multibic is an injectable electrolyte solution designed to correct and maintain sodium, chloride, calcium, and magnesium levels in patients undergoing haemodialysis or receiving intravenous fluid therapy. It helps manage electrolyte disturbances and supports acid‑base balance during renal replacement procedures.

Sodium hydrogen carbonate provides bicarbonate ions that act as a physiological buffer, helping to neutralise excess acidity in the blood. Together with the other electrolytes, it restores normal plasma pH and contributes to overall electrolyte homeostasis during dialysis or IV therapy.

The dose of Multibic is determined by the prescribing clinician based on the patient’s electrolyte status, fluid requirements, and the specific dialysis protocol. Healthcare professionals calculate the appropriate volume and rate of infusion to achieve the desired therapeutic effect.

Safety data for Multibic in pregnancy and lactation are limited. It should only be used if the potential benefit to the mother outweighs any possible risk to the fetus or infant, and the decision must be made by a qualified healthcare provider.

To order Multibic, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed), and import documentation.

Multibic combines four key electrolytes—sodium, chloride, calcium, and magnesium—in a single sterile solution, offering a broader ion profile than many single‑component preparations. This can simplify fluid management during dialysis, but clinicians should compare individual electrolyte concentrations and compatibility with their specific treatment protocols.

Multibic must be stored at 2‑8 °C in a refrigerator, protected from light. Do not freeze or shake the vial. Before use, inspect the solution for particulate matter or discoloration and allow it to reach room temperature if required for administration.

Multibic is administered intravenously, either as a direct infusion during haemodialysis or as a controlled IV drip in other clinical settings. The infusion rate and total volume are set by the treating physician according to the patient’s electrolyte and fluid needs.

Serious risks include hypercalcemia, hypermagnesemia, severe electrolyte imbalance, and rare anaphylactic reactions. Continuous monitoring of serum electrolytes and cardiac rhythm during infusion helps detect and manage these complications promptly.

Multibic should be avoided in patients with known hypersensitivity to any of its components, in those with uncontrolled hypercalcemia or hypermagnesemia, and in individuals where rapid shifts in electrolyte balance could exacerbate existing cardiac or neurological conditions.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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