Product image of Multibic (Sodium Hydrogen Carbonate, Magnesium Chloride Hexahydrate, Sodium Chloride, Calcium Chloride Dihydra) supplied by GNH India

Multibic

Active Ingredient:
Sodium Hydrogen Carbonate, Magnesium Chloride Hexahydrate, Sodium Chloride, Calcium Chloride Dihydra
Origin:
EU

Multibic (Sodium Hydrogen Carbonate, Magnesium Chloride Hexahydrate, Sodium Chloride, Calcium Chloride Dihydra)

Multibic, the active ingredient in Multibic, is an electrolyte solution presented as a solution for injection for haemodialysis and intravenous use. It supplies sodium, chloride, magnesium and calcium ions to restore electrolyte balance and correct acid‑base disturbances in patients undergoing haemodialysis or receiving intravenous electrolyte therapy.

GNH India supplies Multibic as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres and dialysis clinics worldwide. The product conforms to EU quality standards and is manufactured under strict GMP conditions.

Manufacturer / TM Owner

Fresenius Medical Care Deutschland Gmbh

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Indications & Clinical Uses

Multibic is used to manage electrolyte balance and acid‑base status in patients receiving dialysis or intravenous therapy.

  • Haemodialysis: Provides electrolyte replacement to maintain sodium, chloride, magnesium and calcium levels during treatment.
  • Intravenous electrolyte supplementation: Restores electrolyte balance in patients receiving IV therapy.
  • Acid‑base disturbances: Helps correct metabolic acidosis associated with dialysis procedures.

How It Works

  • Multibic delivers sodium, chloride, magnesium and calcium ions directly into the bloodstream or dialysis circuit, thereby replenishing depleted electrolytes and contributing to the maintenance of osmotic pressure and acid‑base equilibrium. The supplied ions participate in physiological pathways that regulate nerve conduction, muscle contraction, and enzymatic reactions, supporting normal cellular function during haemodialysis or intravenous therapy.

Side Effects

Multibic may be associated with infusion‑related reactions and electrolyte disturbances.

Common Side Effects

  • Injection site discomfort: mild pain or erythema at the infusion site.
  • Transient hypotension: temporary drop in blood pressure during administration.
  • Mild nausea: occasional nausea without vomiting.
  • Mild hypermagnesemia: slight elevation of serum magnesium levels.

Serious or Rare Side Effects

  • Severe hypercalcemia: marked increase in calcium that may cause cardiac arrhythmia.
  • Severe hypermagnesemia: high magnesium levels leading to muscle weakness or respiratory depression.
  • Anaphylactoid reaction: rare systemic hypersensitivity response.
  • Significant electrolyte imbalance: dangerous shifts in sodium, chloride, or calcium.
  • Cardiac arrhythmia: abnormal heart rhythm linked to electrolyte disturbances.

Precautions & Warnings

When using Multibic, clinicians should consider several safety measures.

  • Renal function: monitor serum electrolytes in patients with impaired kidney function.
  • Cardiac status: observe for arrhythmias in patients with pre‑existing heart disease.
  • Fluid balance: assess volume status to avoid overload during infusion.
  • Concomitant electrolytes: adjust dosing when other electrolyte‑containing solutions are co‑administered.
  • Pregnancy and lactation: use only if the potential benefit justifies the potential risk.
  • Store at ambient temperature: keep in the original container, protect from light and moisture.

Avoid Interactions

Multibic can interact with other medications that affect electrolyte levels.

Major Interactions (Avoid)

  • Calcium channel blockers: may exacerbate hypercalcemia.
  • Magnesium‑containing laxatives or antacids: risk of additive hypermagnesemia.

Moderate Interactions (Monitor Closely)

  • Loop diuretics: increase renal loss of electrolytes, requiring closer monitoring.
  • ACE inhibitors or ARBs: may alter potassium and overall electrolyte balance.
  • Blood transfusions: can affect calcium concentrations during massive transfusion protocols.

Frequently Asked Questions

Multibic is an injectable electrolyte solution used to replace sodium, chloride, magnesium and calcium ions during haemodialysis and intravenous therapy. It helps maintain electrolyte balance and correct acid‑base disturbances in patients who require dialysis or intravenous electrolyte supplementation.

The active ingredients—sodium hydrogen carbonate, magnesium chloride hexahydrate, sodium chloride and calcium chloride dihydrate—dissolve to release their respective ions. These ions replenish those lost during dialysis or fluid shifts, supporting osmotic balance, nerve conduction, muscle function and acid‑base regulation.

The prescribed dose of Multibic is determined by the treating physician based on the patient’s electrolyte status, dialysis prescription and overall clinical condition. Healthcare professionals calculate the volume and rate of infusion to achieve the desired electrolyte targets.

Safety data for Multibic in pregnancy and lactation are limited. It should only be used if the potential therapeutic benefit outweighs any possible risk to the mother or infant, and the decision must be made by a qualified healthcare provider.

To order Multibic, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and import documentation.

Multibic provides a balanced composition of sodium, chloride, magnesium and calcium, similar to standard dialysis solutions but with the added benefit of magnesium and calcium supplementation. Compared with fluids lacking these ions, Multibic may reduce the need for separate electrolyte supplements during treatment.

Multibic should be stored at ambient temperature, away from direct sunlight and moisture. Keep the vial in its original packaging until use, and avoid exposing it to extreme temperatures or freezing conditions.

Multibic is supplied as a sterile solution for injection. It can be added to the dialysis circuit or infused intravenously according to the clinician’s prescription, using aseptic technique and appropriate infusion equipment.

Serious risks include severe hypercalcemia or hypermagnesemia, which can lead to cardiac arrhythmias, muscle weakness or respiratory depression, and rare anaphylactoid reactions. Continuous monitoring of serum electrolytes and cardiac status is essential during administration.

Multibic should be avoided in patients with known hypersensitivity to any of its components, in those with uncontrolled hypercalcemia or hypermagnesemia, and in individuals where the risk of fluid overload outweighs the benefit. Clinical judgment is required for each case.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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