Product image of Multibic (Sodium Hydrogen Carbonate, Magnesium Chloride Hexahydrate, Sodium Chloride, Calcium Chloride Dihydra) supplied by GNH India

Multibic

Active Ingredient:
Sodium Hydrogen Carbonate, Magnesium Chloride Hexahydrate, Sodium Chloride, Calcium Chloride Dihydra
Origin:
EU

Multibic (Sodium Hydrogen Carbonate, Magnesium Chloride Hexahydrate, Sodium Chloride, Calcium Chloride Dihydra)

Sodium hydrogen carbonate, magnesium chloride hexahydrate, sodium chloride and calcium chloride dihydrate, the active ingredients in Multibic, are an electrolyte solution presented as an intravenous solution for haemodialysis and intravenous use. It provides essential electrolytes and buffering capacity to support patients undergoing renal replacement therapy.
GNH India supplies Multibic as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres and dialysis clinics worldwide.

Manufacturer / TM Owner

Fresenius Medical Care Deutschland Gmbh

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Indications & Clinical Uses

Multibic is an electrolyte solution used in renal replacement and fluid management therapies. It is employed in the following clinical situations:

  • Haemodialysis: maintains electrolyte balance and buffering during the dialysis procedure.
  • Intravenous fluid replacement: restores essential electrolytes in patients requiring volume support.
  • Acute renal failure: assists in correcting electrolyte disturbances associated with impaired kidney function.

How It Works

  • Multibic delivers sodium, chloride, calcium, magnesium and bicarbonate ions directly into the bloodstream, supplying the electrolytes needed for cellular function and acid‑base regulation. The bicarbonate component provides buffering capacity, helping to correct metabolic acidosis, while the calcium and magnesium ions support cardiac and neuromuscular stability during haemodialysis.

Side Effects

Multibic may be associated with a range of adverse reactions. Monitoring during administration is recommended.

Common Side Effects

  • Mild nausea or vomiting: transient gastrointestinal discomfort.
  • Transient hypotension: temporary drop in blood pressure during infusion.
  • Headache or dizziness: related to rapid electrolyte shifts.

Serious or Rare Side Effects

  • Severe hypercalcemia: elevated calcium levels causing cardiac arrhythmia.
  • Anaphylactic reaction: rare but potentially life‑threatening hypersensitivity.
  • Metabolic alkalosis: excessive bicarbonate leading to pH imbalance.

Precautions & Warnings

Before using Multibic, consider the following safety measures:

  • Monitor electrolytes: regularly assess serum sodium, calcium, magnesium and bicarbonate levels.
  • Cardiac assessment: evaluate ECG for arrhythmias, especially in patients with cardiac disease.
  • Fluid balance: ensure appropriate volume status to avoid overload.
  • Compatibility: verify compatibility with other IV solutions and dialysis equipment.
  • Contraindications: avoid in patients with known severe hypercalcemia or hypersensitivity to any component.
  • Store at controlled room temperature: keep in original container, protect from light and moisture.

Avoid Interactions

Multibic can interact with other medications and solutions that affect electrolyte balance.

Major Interactions (Avoid)

  • Concurrent high‑calcium IV solutions: may precipitate severe hypercalcemia.
  • High‑dose magnesium preparations: increase risk of hypermagnesemia.
  • Sodium bicarbonate infusions: can cause excessive alkalosis.

Moderate Interactions (Monitor Closely)

  • Potassium‑sparing diuretics: monitor serum potassium and overall electrolyte profile.
  • Certain anticoagulants used during dialysis: watch for altered clotting parameters.
  • Blood products with citrate: may affect calcium levels, requiring close observation.

Frequently Asked Questions

Multibic is an intravenous electrolyte solution used primarily during haemodialysis to provide essential electrolytes and buffering capacity, and it can also be employed for intravenous fluid replacement in patients who need rapid correction of electrolyte imbalances.

The formulation supplies sodium, chloride, calcium, magnesium and bicarbonate ions directly into the bloodstream. These ions help maintain cellular electrolyte balance, support cardiac and neuromuscular function, and the bicarbonate component buffers metabolic acids, stabilising blood pH during dialysis.

The dose of Multibic is determined by the prescribing clinician based on the patient’s individual dialysis prescription, electrolyte status and fluid requirements. Healthcare professionals set the infusion rate and total volume according to established clinical protocols.

Safety data for Multibic in pregnancy and lactation are limited. It should only be used if the potential benefit to the mother outweighs any possible risk to the fetus or infant, and the decision should be made by a qualified healthcare provider.

To order Multibic, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and import documentation.

Multibic contains a balanced mix of sodium, chloride, calcium, magnesium and bicarbonate, similar to many standard dialysis solutions. Compared with fluids lacking bicarbonate, Multibic offers additional buffering capacity, which can help better control metabolic acidosis during treatment.

Multibic should be stored at controlled room temperature, below 25 °C, in its original packaging. Protect the solution from direct sunlight, moisture and extreme temperature fluctuations to maintain its stability and sterility.

Multibic is administered intravenously, either directly into the patient’s bloodstream or through the dialysis circuit as part of the haemodialysis fluid. The infusion rate and total volume are set by the dialysis machine or clinician according to the prescribed treatment plan.

Serious risks include severe hypercalcemia, which can cause cardiac arrhythmias, metabolic alkalosis from excess bicarbonate, and rare anaphylactic reactions. Prompt monitoring of electrolyte levels and patient vital signs helps mitigate these risks.

Multibic should be avoided in patients with known hypersensitivity to any of its components, those with severe hypercalcemia, or individuals for whom the electrolyte composition would exacerbate existing electrolyte disorders, unless a healthcare professional determines it is appropriate.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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