Product image of Multibic (Sodium Hydrogen Carbonate, Magnesium Chloride Hexahydrate, Sodium Chloride, Calcium Chloride Dihydra) supplied by GNH India

Multibic

Active Ingredient:
Sodium Hydrogen Carbonate, Magnesium Chloride Hexahydrate, Sodium Chloride, Calcium Chloride Dihydra
Origin:
EU

Multibic (Sodium Hydrogen Carbonate, Magnesium Chloride Hexahydrate, Sodium Chloride, Calcium Chloride Dihydra)

Sodium hydrogen carbonate, the active ingredient in Multibic, is an electrolyte component presented as an intravenous solution for haemodialysis use. It helps correct acid‑base balance and replenish electrolytes in patients undergoing dialysis, alongside magnesium chloride, sodium chloride and calcium chloride which together support electrolyte homeostasis.

GNH India supplies Multibic as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals and dialysis centres worldwide.

Manufacturer / TM Owner

Fresenius Medical Care Deutschland Gmbh

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Indications & Clinical Uses

Multibic is used as an intravenous electrolyte and buffer solution during haemodialysis and related renal replacement therapies.

  • Metabolic acidosis: provides bicarbonate to raise blood pH and correct acidemia.
  • Electrolyte imbalance: restores sodium, chloride, calcium and magnesium concentrations lost during dialysis.
  • Calcium supplementation: supplies calcium ions to support cardiac contractility and neuromuscular function in dialysis patients.

How It Works

  • Multibic delivers bicarbonate ions that act as a physiological buffer, neutralising excess hydrogen ions and raising systemic pH. Simultaneously, the solution supplies sodium, chloride, calcium and magnesium ions, which are incorporated into plasma and intracellular compartments to maintain osmotic balance, vascular tone and neuromuscular excitability during haemodialysis.

Side Effects

Multibic may be associated with electrolyte‑related adverse reactions and infusion‑related events.

Common Side Effects

  • Hypernatremia: elevated serum sodium levels.
  • Hypercalcemia: increased calcium concentration.
  • Hypermagnesemia: raised magnesium levels.
  • Fluid overload: excess extracellular fluid volume.
  • Hypotension: drop in blood pressure during infusion.
  • Local irritation at infusion site.

Serious or Rare Side Effects

  • Severe electrolyte disturbances leading to cardiac arrhythmia.
  • Pulmonary edema from fluid overload.
  • Anaphylactic or severe hypersensitivity reaction.
  • Metabolic alkalosis from excessive bicarbonate.
  • Thrombophlebitis at the catheter site.
  • Acute kidney injury exacerbation.

Precautions & Warnings

When using Multibic, clinicians should observe specific safety measures.

  • Electrolyte monitoring: regularly check serum sodium, calcium, magnesium and bicarbonate levels.
  • Fluid balance: assess patient’s volume status to avoid overload.
  • Cardiac monitoring: observe for arrhythmias in patients with electrolyte shifts.
  • Contraindications: avoid in patients with known severe hypercalcemia or hypermagnesemia.
  • Compatibility: ensure solution compatibility with other IV fluids and medications.
  • Store at ambient temperature: keep in original container, protect from direct sunlight and moisture.

Avoid Interactions

Multibic can interact with other agents that affect electrolyte balance or acid‑base status.

Major Interactions (Avoid)

  • Calcium channel blockers: may potentiate hypercalcemia.
  • Magnesium‑containing laxatives or antacids: increase risk of hypermagnesemia.
  • High‑dose sodium bicarbonate: can cause severe metabolic alkalosis.

Moderate Interactions (Monitor Closely)

  • Loop diuretics: may exacerbate electrolyte shifts.
  • ACE inhibitors or ARBs: influence potassium and sodium handling.
  • Other intravenous electrolyte solutions: risk of cumulative overload.
  • Blood transfusions: may affect calcium levels.

Frequently Asked Questions

Multibic is an intravenous electrolyte and buffer solution used primarily during haemodialysis to correct metabolic acidosis and replenish sodium, chloride, calcium and magnesium that are lost or altered during the procedure.

Sodium hydrogen carbonate provides bicarbonate ions that act as a physiological buffer, neutralising excess hydrogen ions in the blood and helping to raise systemic pH, while the accompanying electrolytes restore normal plasma concentrations.

The dose of Multibic is determined by the prescribing clinician based on the patient’s laboratory values, dialysis prescription and fluid balance. It is administered intravenously under medical supervision.

Safety data for Multibic in pregnancy and lactation are limited. Its use should be considered only if the potential benefit justifies any potential risk to the mother or infant, and decisions are made by the treating physician.

To order Multibic, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and necessary import documentation.

Multibic combines bicarbonate buffering with a balanced mix of sodium, chloride, calcium and magnesium, offering a comprehensive approach to acid‑base and electrolyte management. Alternative solutions may focus on single electrolytes or different buffer systems, so choice depends on the specific clinical needs and institutional protocols.

Multibic should be stored at ambient temperature, protected from direct sunlight and moisture, and kept in its original sealed container until use. Do not freeze the solution and inspect for particulate matter before administration.

Multibic is given intravenously, typically through a dialysis circuit or a dedicated IV line, as directed by the dialysis prescription. Administration rate and volume are adjusted according to the patient’s electrolyte and acid‑base targets.

Serious risks include severe electrolyte disturbances such as hypercalcemia, hypermagnesemia or hypernatremia, which can lead to cardiac arrhythmias, pulmonary edema, or metabolic alkalosis. Prompt monitoring of laboratory values is essential to mitigate these risks.

Multibic should be avoided in patients with known severe hypercalcemia, hypermagnesemia, uncontrolled fluid overload, or documented hypersensitivity to any of its components. Clinical judgment is required for patients with unstable cardiac conditions.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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