Product image of Multibiotic (Bacitracin Zinc, Neomycin Sulfate, Polymyxin B Sulfate) supplied by GNH India

Multibiotic

Active Ingredient:
Bacitracin Zinc, Neomycin Sulfate, Polymyxin B Sulfate
Origin:
EU

Multibiotic (Bacitracin Zinc, Neomycin Sulfate, Polymyxin B Sulfate)

Bacitracin Zinc, Neomycin Sulfate and Polymyxin B Sulfate, the active ingredients in Multibiotic, are antibacterial agents presented as a topical formulation for external use. They treat minor skin infections, cuts, abrasions and superficial burns in both adults and children.

GNH India supplies Multibiotic as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Chema Elektromet Spoldzielnia Pracy

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Indications & Clinical Uses

Multibiotic is a topical antibacterial indicated for superficial bacterial skin conditions.

  • Minor skin infections: reduces bacterial load and promotes healing of localized infections.
  • Cuts, abrasions, and burns: prevents bacterial colonisation and infection of superficial wounds.
  • Superficial bacterial skin infections: treats early‑stage cellulitis and impetigo caused by susceptible organisms.

How It Works

  • Bacitracin zinc interferes with bacterial cell‑wall synthesis, neomycin sulfate binds to the 30S ribosomal subunit to inhibit protein synthesis, and polymyxin B sulfate disrupts the bacterial cell‑membrane integrity, leading to rapid cell death of susceptible Gram‑positive and Gram‑negative organisms.

Side Effects

Common Side Effects

  • Skin irritation: mild redness or itching at the application site.
  • Burning sensation: transient warmth or tingling when first applied.
  • Dryness: local skin dryness or flaking.

Serious or Rare Side Effects

  • Severe allergic reaction: anaphylaxis or angioedema requiring immediate medical attention.
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis: extensive skin detachment.
  • Contact urticaria: hives or swelling localized to the treated area.

Precautions & Warnings

Before using Multibiotic, consider the following precautions.

  • Allergy assessment: confirm no known hypersensitivity to bacitracin, neomycin or polymyxin B.
  • Age restriction: avoid extensive use on neonates without medical supervision.
  • Open wounds: limit application to intact skin unless directed by a clinician.
  • Concurrent topical products: do not layer other medicated ointments on the same area.
  • Pregnancy and lactation: consult a healthcare professional before use.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Multibiotic may interact with other agents as described below.

Major Interactions (Avoid)

  • Systemic aminoglycosides: increased risk of nephrotoxicity when neomycin is absorbed.
  • Systemic polymyxin B: additive nephrotoxic potential.
  • Other topical antibiotics: may heighten local irritation.

Moderate Interactions (Monitor Closely)

  • Topical corticosteroids: may reduce the antibacterial efficacy.
  • Antifungal creams: potential antagonistic effect on bacterial coverage.
  • Silver‑containing dressings: could interfere with the antibacterial activity of the formulation.

Frequently Asked Questions

Multibiotic is a topical antibacterial preparation indicated for minor skin infections, superficial bacterial skin conditions, and for preventing infection in cuts, abrasions and superficial burns. It is applied directly to the affected area to reduce bacterial colonisation and support wound healing.

Bacitracin zinc blocks bacterial cell‑wall synthesis, neomycin sulfate interferes with protein synthesis by binding the 30S ribosomal subunit, and polymyxin B sulfate disrupts the bacterial cell‑membrane integrity. Together they provide a broad‑spectrum antibacterial effect against Gram‑positive and Gram‑negative organisms.

The dosage and frequency of Multibiotic are determined by the prescribing healthcare professional based on the type and extent of the skin lesion. Patients should follow the specific instructions provided by their clinician or pharmacist.

Safety data for Multibiotic in pregnancy and lactation are limited. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss potential risks and benefits with their healthcare provider before using the product.

To order Multibiotic, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Multibiotic combines three agents—bacitracin zinc, neomycin sulfate and polymyxin B sulfate—offering broader antibacterial coverage than single‑agent preparations such as bacitracin alone. This combination can be more effective against mixed‑flora infections but may also carry a higher risk of local allergic reactions.

Multibiotic should be stored at room temperature, below 25 °C, in its original packaging. Keep the container tightly closed, protect it from moisture and direct sunlight, and avoid freezing the product.

Multibiotic is applied topically to clean, dry skin. A thin layer is spread over the affected area, usually 1–3 times daily, or as directed by a healthcare professional. Hands should be washed before and after application.

Serious risks include severe allergic reactions such as anaphylaxis, Stevens‑Johnson syndrome, toxic epidermal necrolysis, and systemic toxicity if large amounts are absorbed. Immediate medical attention is required if signs of a severe reaction develop.

Multibiotic should not be used by individuals with a known hypersensitivity to any of its components—bacitracin zinc, neomycin sulfate or polymyxin B sulfate. It is also contraindicated on large, deep wounds, mucous membranes, or in patients where systemic absorption could pose a risk without medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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