Product image of Multihance (Gadobenate Dimeglumine) supplied by GNH India

Multihance

Active Ingredient:
Gadobenate Dimeglumine
Origin:
EU

Multihance (Gadobenate Dimeglumine)

Gadobenate dimeglumine, the active ingredient in Multihance, is a gadolinium-based contrast agent presented as a 0.5 mmol/mL injection solution for intravenous use. It enhances magnetic resonance imaging of specific organ systems in patients undergoing diagnostic scans.

GNH India supplies Multihance as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Bracco Imaging S.P.A.

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Indications & Clinical Uses

  • Multihance is used as a gadolinium‑based contrast agent to improve magnetic resonance imaging of various organ systems.
  • Central nervous system MRI: provides enhanced visualization of brain and spinal cord structures for diagnostic assessment.
  • Liver MRI: improves detection and characterization of focal hepatic lesions.
  • Cardiovascular MRI: highlights vascular anatomy and myocardial perfusion for functional evaluation.
  • Musculoskeletal MRI: increases contrast between bone, cartilage, and soft‑tissue structures for accurate diagnosis.

How It Works

  • Gadobenate dimeglumine is a paramagnetic gadolinium chelate that shortens the T1 relaxation time of nearby water protons. After intravenous injection, it distributes in the extracellular fluid and accumulates in tissues with increased vascularity, thereby increasing signal intensity on T1‑weighted MRI sequences and improving lesion detection.

Side Effects

Adverse reactions may occur following administration of Multihance.

Common Side Effects

  • Warmth or flushing sensation at the injection site
  • Nausea or mild vomiting
  • Headache
  • Dizziness or light‑headedness
  • Transient metallic taste
  • Mild injection‑site pain

Serious or Rare Side Effects

  • Severe allergic reactions including anaphylaxis
  • Nephrogenic systemic fibrosis in patients with severe renal impairment
  • Acute hypotension or cardiovascular collapse
  • Cardiac arrest (rare)
  • Severe respiratory distress
  • Persistent skin rash or urticaria

Precautions & Warnings

  • Multihance should be used with attention to patient safety and handling requirements.
  • Renal function assessment: evaluate kidney function before administration.
  • Pregnancy considerations: safety not established; use only if essential.
  • Allergy screening: avoid in patients with known hypersensitivity to gadolinium agents.
  • Severe renal impairment: contraindicated due to NSF risk.
  • Hydration status: ensure adequate hydration to support renal clearance.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Potential drug interactions should be reviewed prior to use.

Major Interactions (Avoid)

  • Other gadolinium‑based contrast agents: cumulative exposure may increase NSF risk.
  • Nephrotoxic medications (e.g., aminoglycosides, high‑dose NSAIDs): may exacerbate renal dysfunction.
  • High‑dose intravenous iron: can interfere with MRI interpretation.

Moderate Interactions (Monitor Closely)

  • Beta‑blockers: may mask early signs of hypersensitivity.
  • Diuretics: affect fluid balance during contrast administration.
  • Antihistamines: may reduce efficacy of pre‑medication protocols.

Frequently Asked Questions

Multihance is a gadolinium‑based contrast agent used to enhance magnetic resonance imaging of the brain, liver, heart, and musculoskeletal system. It improves the visibility of anatomical structures and lesions, aiding radiologists in accurate diagnosis.

Gadobenate dimeglumine is a paramagnetic chelate that shortens the T1 relaxation time of nearby water protons. After intravenous injection it distributes in the extracellular space, increasing signal intensity on T1‑weighted MRI sequences and highlighting vascularized tissues.

The dose of Multihance is determined by the prescribing physician based on the patient’s weight, renal function, and the specific MRI protocol. Exact dosing information is provided in the product labeling and should not be altered without medical guidance.

Safety of Multihance during pregnancy and lactation has not been established. It should only be used when clearly needed and after a risk‑benefit assessment by the treating physician. Breastfeeding mothers should discuss potential exposure with their healthcare provider.

To order Multihance, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and import documentation.

Multihance (gadobenate dimeglumine) offers high relaxivity, providing strong signal enhancement at lower doses compared with some agents such as gadobutrol. It also has a partial hepatobiliary excretion pathway, which can improve liver lesion detection, while maintaining a safety profile similar to other macrocyclic agents.

Multihance should be stored refrigerated at 2‑8 °C, protected from light, and must not be frozen or shaken. Keep the vial in its original packaging until use and discard any solution that appears discolored or contains particles.

Multihance is administered by intravenous injection, typically using a power injector at a rate recommended by the imaging protocol. The injection is performed under medical supervision, and patients are monitored for any immediate adverse reactions during and after administration.

The most serious risks include severe allergic reactions such as anaphylaxis and nephrogenic systemic fibrosis (NSF) in patients with severe renal impairment. Prompt recognition and management of these reactions are essential, and the agent should be avoided in high‑risk individuals.

Multihance is contraindicated in patients with known hypersensitivity to gadobenate dimeglumine or any component of the formulation, and in those with severe renal impairment (eGFR < 30 mL/min/1.73 m²) due to the risk of NSF. Caution is also advised for patients with a history of severe allergic reactions.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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