Product image of Multiparin (Heparin Sodium) supplied by GNH India

Multiparin

Active Ingredient:
Heparin Sodium
Origin:
EU

Multiparin (Heparin Sodium)

Heparin Sodium, the active ingredient in Multiparin, is an anticoagulant presented as an injectable solution for intravenous use. It is employed to prevent and treat clot formation in patients at risk of venous thromboembolism, deep vein thrombosis and during invasive procedures.
GNH India supplies Multiparin as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Wockhardt Uk Ltd

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Indications & Clinical Uses

Multiparin is an anticoagulant that acts on the coagulation cascade to prevent pathological clot formation.

  • Prevention and treatment of venous thromboembolism: reduces incidence of deep vein clots and pulmonary emboli in at‑risk patients.
  • Prophylaxis of deep vein thrombosis and pulmonary embolism: administered peri‑operatively to lower postoperative clot risk.
  • Anticoagulation during cardiac surgery and other invasive procedures: maintains anticoagulation to prevent intra‑operative thrombosis.

How It Works

  • Heparin Sodium binds to antithrombin III, accelerating its inhibition of activated clotting factors, principally thrombin (factor IIa) and factor Xa. This rapid inactivation of key enzymes in the coagulation cascade diminishes fibrin formation, thereby preventing the development and propagation of thrombi.

Side Effects

Adverse reactions may occur with any anticoagulant therapy.

Common Side Effects

  • Bleeding at the injection site
  • Minor bruising or hematoma formation
  • Nausea
  • Transient hypotension

Serious or Rare Side Effects

  • Severe hemorrhage, including intracranial bleeding
  • Heparin‑induced thrombocytopenia (HIT)
  • Allergic reactions, potentially anaphylaxis
  • Elevated liver enzymes or hepatic dysfunction

Precautions & Warnings

Careful assessment and monitoring are required when using Multiparin.

  • Renal impairment: monitor anti‑Xa levels and adjust therapy as clearance may be reduced.
  • History of bleeding disorders: evaluate risk‑benefit before initiation.
  • Concurrent use of other anticoagulants: increased risk of major bleeding.
  • Pregnancy: consider only when clearly indicated, as safety data are limited.
  • Surgical procedures: discontinue prior to major surgery to reduce intra‑operative bleeding.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze.

Avoid Interactions

Multiparin may interact with several drug classes, altering bleeding risk or anticoagulant effect.

Major Interactions (Avoid)

  • Direct thrombin inhibitors (e.g., dabigatran): additive anticoagulant effect.
  • Antiplatelet agents (e.g., aspirin, clopidogrel): heightened bleeding risk.
  • High‑dose fibrinolytics (e.g., alteplase): increased hemorrhage.

Moderate Interactions (Monitor Closely)

  • NSAIDs: may exacerbate bleeding tendencies.
  • SSRIs or SNRIs: potential for increased mucosal bleeding.
  • ACE inhibitors: may potentiate hypotensive episodes when combined with heparin.

Frequently Asked Questions

Multiparin is an injectable form of heparin sodium used to prevent and treat venous thromboembolism, including deep vein thrombosis and pulmonary embolism, and to provide anticoagulation during cardiac surgery or other invasive procedures where clot formation is a concern.

Heparin sodium binds to antithrombin III, greatly enhancing its ability to inactivate thrombin (factor IIa) and factor Xa. By blocking these key enzymes, the drug interrupts the coagulation cascade, reducing fibrin generation and preventing new clots from forming.

The dose of Multiparin is individualized and must be determined by a qualified prescriber based on the patient’s clinical condition, weight, renal function, and the specific indication. No standard dosing regimen is provided here.

Safety data for heparin sodium in pregnancy and lactation are limited. It may be used during pregnancy only when the potential benefit justifies the potential risk to the fetus, and breastfeeding decisions should be made in consultation with a healthcare professional.

To order Multiparin, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where required) and import documentation.

Multiparin (heparin sodium) provides rapid anticoagulation via antithrombin activation, making it suitable for acute settings and procedures. Unlike oral direct oral anticoagulants, it requires intravenous administration and laboratory monitoring, but offers immediate reversibility with protamine sulfate, which is advantageous in surgical contexts.

Multiparin should be stored at 2‑8 °C in a refrigerator, protected from light, and must not be frozen or shaken. Use aseptic technique during preparation, and keep the product in its original packaging until ready for administration.

Multiparin is administered by intravenous injection or infusion under the supervision of a qualified healthcare professional. The rate and duration of infusion are determined by the prescriber and may be adjusted according to laboratory monitoring of anticoagulant effect.

The most serious risks include severe or uncontrolled bleeding, heparin‑induced thrombocytopenia (HIT), and rare allergic reactions such as anaphylaxis. Patients should be monitored for signs of bleeding, sudden platelet count drops, or hypersensitivity during therapy.

Multiparin is contraindicated in patients with known hypersensitivity to heparin or pork‑derived products, active major bleeding, or a history of heparin‑induced thrombocytopenia. Caution is also advised for those with severe thrombocytopenia, uncontrolled hypertension, or recent intracranial surgery.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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