Product image of Muscoril Dolore (Diclofenac Diethylamine) supplied by GNH India

Muscoril Dolore

Active Ingredient:
Diclofenac Diethylamine
Origin:
EU

Muscoril Dolore (Diclofenac Diethylamine)

Diclofenac diethylamine, the active ingredient in Muscoril Dolore, is a non‑steroidal anti‑inflammatory drug (NSAID) presented as a topical formulation for cutaneous use. It treats localized musculoskeletal pain, joint pain, back pain, sprains and strains in adults.

GNH India supplies Muscoril Dolore as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Doc Generici S.R.L.

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Indications & Clinical Uses

Diclofenac diethylamine is a topical NSAID used to manage inflammatory musculoskeletal conditions.

  • Localized musculoskeletal pain: provides targeted pain relief and reduces inflammation at the application site.
  • Joint pain: alleviates discomfort and swelling in affected joints.
  • Back pain: helps diminish lumbar muscle strain and associated soreness.

How It Works

  • Diclofenac diethylamine penetrates the skin and reversibly inhibits cyclooxygenase‑1 and cyclooxygenase‑2 enzymes in peripheral tissues. This inhibition lowers prostaglandin synthesis, thereby decreasing inflammation, edema, and pain signals at the site of application.

Side Effects

Topical diclofenac may cause skin‑related reactions at the application site.

Common Side Effects

  • Skin irritation: redness or mild burning sensation.
  • Itching: localized pruritus.
  • Dryness: flaky or dry skin.
  • Erythema: superficial redness.
  • Contact dermatitis: allergic skin reaction.
  • Stinging: transient sharp sensation.

Serious or Rare Side Effects

  • Anaphylaxis: severe allergic reaction requiring emergency care.
  • Stevens‑Johnson syndrome: rare but serious skin disorder.
  • Toxic epidermal necrolysis: extensive skin detachment.
  • Systemic NSAID toxicity: rare systemic effects if absorbed in large amounts.
  • Ulceration: gastrointestinal ulcer risk if systemic exposure occurs.
  • Hepatic injury: liver function abnormalities.

Precautions & Warnings

When using Muscoril Dolore, consider the following safety measures.

  • Hypersensitivity: avoid if known allergy to diclofenac or other NSAIDs.
  • Asthma or nasal polyps: use with caution as it may trigger bronchospasm.
  • Broken or infected skin: do not apply to compromised skin to prevent systemic absorption.
  • Duration of use: limit application to the affected area and do not exceed 7 days unless directed by a healthcare professional.
  • Store at room temperature: keep in the original pack, protect from moisture and direct sunlight.

Avoid Interactions

Topical diclofenac can interact with other medicines, especially when systemic absorption occurs.

Major Interactions (Avoid)

  • Systemic NSAIDs: concurrent use increases risk of gastrointestinal bleeding.
  • Anticoagulants (e.g., warfarin, DOACs): heightened bleeding tendency.
  • Corticosteroid creams: may enhance skin atrophy.

Moderate Interactions (Monitor Closely)

  • Diuretics: potential reduction in renal clearance of NSAIDs.
  • Antihypertensives: possible attenuation of blood‑pressure‑lowering effect.

Frequently Asked Questions

Muscoril Dolore is a topical formulation containing diclofenac diethylamine. It is indicated for the relief of localized musculoskeletal pain, joint pain, back pain, and discomfort associated with sprains and strains. The medication works at the site of application to reduce inflammation and provide analgesia.

Diclofenac diethylamine inhibits the cyclooxygenase‑1 and cyclooxygenase‑2 enzymes in peripheral tissues. By blocking these enzymes, it reduces the synthesis of prostaglandins, which are mediators of inflammation and pain. The result is decreased swelling and localized pain relief where the gel is applied.

The specific dose and frequency of Muscoril Dolore are determined by the prescribing healthcare professional based on the severity of symptoms, the area to be treated, and patient factors. Patients should follow the prescriber’s instructions and the product label for proper application.

Safety of topical diclofenac during pregnancy or lactation has not been definitively established. Healthcare providers generally advise caution and may recommend alternative therapies. Patients who are pregnant, planning to become pregnant, or breastfeeding should discuss potential risks with their physician.

To place an order, submit an enquiry on the Muscoril Dolore product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Muscoril Dolore contains diclofenac diethylamine, a potent NSAID with strong COX inhibition. Compared with other topical NSAIDs such as ibuprofen or ketoprofen gels, diclofenac often provides more rapid and pronounced anti‑inflammatory effects, though individual response may vary. Choice of product should be guided by clinical judgment and patient tolerance.

Muscoril Dolore should be stored at room temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture, excessive heat, and direct sunlight to maintain stability and efficacy.

The gel is applied to clean, dry skin over the painful area. A thin layer is spread gently and massaged until absorbed. Hands should be washed after application, and the medication should not be covered with occlusive dressings unless directed by a healthcare professional.

While generally well tolerated, serious adverse reactions can include severe allergic responses such as anaphylaxis, Stevens‑Johnson syndrome, toxic epidermal necrolysis, and systemic NSAID toxicity if significant absorption occurs. Patients should discontinue use and seek immediate medical attention if they notice signs of a severe reaction.

Muscoril Dolore is contraindicated in individuals with known hypersensitivity to diclofenac, other NSAIDs, or any component of the formulation. It should also be avoided on broken, infected, or inflamed skin, and in patients with a history of severe allergic skin reactions to topical medications.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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