Product image of Muse (Alprostadil) supplied by GNH India

Muse

Active Ingredient:
Alprostadil
Origin:
EU

Muse (Alprostadil)

Alprostadil, the active ingredient in Muse, is a prostaglandin analog presented as a urethral suppository for urethral use. It is indicated for the treatment of erectile dysfunction in adult males by enhancing penile blood flow. The medication is administered directly into the urethra, where it exerts its pharmacologic effect locally.

GNH India supplies Muse as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. Our distribution network ensures consistent quality and regulatory compliance across EU and global markets.

Manufacturer / TM Owner

Viatris Healthcare Limited

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Indications & Clinical Uses

Alprostadil is a prostaglandin analog used in the management of erectile dysfunction, a condition characterized by insufficient penile blood flow.

  • Erectile dysfunction: improves erection quality sufficient for sexual activity.
  • Erectile dysfunction secondary to diabetes: enhances penile blood flow in diabetic men.
  • Post‑prostatectomy penile rehabilitation: supports tissue health and facilitates recovery of erectile function.

How It Works

  • Alprostadil is a synthetic prostaglandin E1 that binds to prostaglandin I2 (IP) receptors on penile smooth muscle, activating adenylate cyclase and increasing intracellular cyclic AMP. Elevated cAMP leads to smooth‑muscle relaxation, vasodilation of penile arteries, and increased arterial inflow, resulting in an erection when combined with sexual stimulation.

Side Effects

Alprostadil may cause a range of adverse reactions, most of which are localized to the genital area.

Common Side Effects

  • Penile pain: mild to moderate discomfort during or after administration.
  • Urethral burning or stinging: transient sensation at the site of insertion.
  • Headache: occasional mild headache.
  • Light‑headedness: brief dizziness after dosing.
  • Penile erythema: redness of the penis.
  • Vaginal discharge (partner exposure): temporary irritation.

Serious or Rare Side Effects

  • Priapism: prolonged erection lasting more than four hours.
  • Severe hypotension: marked drop in blood pressure, especially when combined with nitrates.
  • Allergic reaction: rash, itching, or swelling.
  • Penile fibrosis: rare development of scar tissue.
  • Infection: local urethral infection at the insertion site.

Precautions & Warnings

Before using Muse, clinicians should evaluate patient suitability and monitor for potential complications.

  • Cardiovascular assessment: ensure the patient can safely engage in sexual activity.
  • Concomitant nitrate therapy: avoid due to risk of severe hypotension.
  • Recent penile trauma or surgery: defer use until healed.
  • Hematologic disorders: monitor for bleeding tendencies.
  • Allergy history: screen for prostaglandin or formulation component hypersensitivity.
  • Store at ambient temperature: keep below 25 °C in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Alprostadil may interact with other medications that affect vascular tone or coagulation.

Major Interactions (Avoid)

  • Nitrates: combined use can cause profound hypotension.
  • Phosphodiesterase‑5 inhibitors (e.g., sildenafil): increased risk of priapism.
  • Alpha‑blockers: additive blood‑pressure‑lowering effect.

Moderate Interactions (Monitor Closely)

  • Antihypertensive agents: monitor blood pressure for additive effects.
  • Warfarin or other anticoagulants: observe for changes in INR.
  • Alcohol: may enhance hypotensive response.
  • Antihistamines: watch for increased dizziness.

Frequently Asked Questions

Muse is a urethral suppository containing alprostadil that is prescribed to treat erectile dysfunction in adult men. The medication works locally to increase blood flow to the penis, helping achieve an erection sufficient for sexual activity.

Alprostadil is a synthetic prostaglandin E1 that activates IP receptors on penile smooth muscle, raising cyclic AMP levels. This biochemical cascade relaxes smooth muscle, dilates penile arteries, and enhances blood flow, facilitating erection when sexual stimulation occurs.

The dose of Muse is determined by the prescribing clinician based on the patient’s condition, response, and tolerability. The prescriber selects the appropriate number of suppositories and timing according to individual therapeutic needs.

Muse is intended for use in adult males with erectile dysfunction. Its safety in pregnancy or breastfeeding has not been established, and it is not recommended for women. Women who are pregnant, planning pregnancy, or nursing should avoid handling the product without appropriate protective measures.

To order Muse, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Muse delivers alprostadil directly to the urethra, providing a rapid local effect without systemic exposure. Compared with oral PDE5 inhibitors, it can be effective in patients who do not respond to oral therapy or who have contraindications to those drugs. Unlike injectable alprostadil, Muse avoids the need for intracavernosal injection.

Muse should be stored at ambient temperature, below 25 °C, in its original sealed container. Protect the product from moisture, direct sunlight, and extreme temperatures to maintain its stability and efficacy.

Muse is administered by inserting the suppository into the urethra, typically 5–10 minutes before anticipated sexual activity. The patient should follow the prescriber’s instructions for proper insertion technique and timing to achieve optimal results.

The most serious risks include priapism—a prolonged erection lasting more than four hours—and severe hypotension, especially when combined with nitrates or other vasodilators. Prompt medical attention is required if these events occur.

Muse is contraindicated in men with known hypersensitivity to alprostadil or any formulation component, those using nitrates, patients with severe cardiovascular disease that limits sexual activity, and individuals with penile anatomical abnormalities or recent penile surgery.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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