Muse (Alprostadil)

Alprostadil is a synthetic analogue of prostaglandin E1. It binds to prostaglandin E1 receptors on the smooth muscle of the corpus cavernosum, activating adenylate cyclase and raising cyclic AMP levels. The rise in cAMP causes smooth‑muscle relaxation, vasodilation of penile arteries, and enhanced arterial inflow, resulting in an erection.

The dose of Muse is determined by the prescribing clinician based on the individual patient's condition, response, and tolerability. The product is supplied as a pre‑measured urethral suppository, and the prescriber specifies the frequency and any dose adjustments needed.

Safety of alprostadil, including Muse, has not been established in pregnancy or lactation. The product is not indicated for use in pregnant or breastfeeding women, and it should be avoided unless a clear benefit outweighs potential risks as assessed by a qualified healthcare professional.

To order Muse, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and the necessary import documentation.

Muse delivers alprostadil directly to the urethra, offering rapid local action without systemic exposure. Compared with oral phosphodiesterase‑5 inhibitors, Muse may be effective when oral agents fail or are contraindicated. Compared with intracavernosal alprostadil injections, the suppository avoids needle use but may cause urethral irritation.

Muse should be stored at room temperature, below 25 °C, in its original packaging. Protect the product from moisture and direct light. Do not refrigerate or freeze. Keep out of reach of children and handle with clean, dry hands to maintain sterility of the suppository.

Muse is administered by inserting the urethral suppository into the male urethra, typically 5–10 minutes before anticipated sexual activity. The patient should follow the prescriber’s instructions regarding positioning, timing, and any post‑administration precautions to ensure optimal absorption and effectiveness.

The most serious risks include priapism—a prolonged erection lasting more than four hours that requires immediate medical attention—severe hypotension leading to dizziness or fainting, and rare allergic reactions such as rash, swelling, or anaphylaxis. Patients should be educated to seek urgent care if these events occur.

Muse should not be used by individuals with known hypersensitivity to alprostadil or other prostaglandin E1 analogues, men with severe cardiovascular disease (e.g., recent myocardial infarction), patients with bleeding disorders on anticoagulant therapy without medical supervision, and anyone for whom erectile dysfunction therapy is contraindicated.