Muse (Alprostadil)

Alprostadil is a prostaglandin E1 analog that binds to receptors on penile smooth‑muscle cells, stimulating adenylate cyclase and raising intracellular cAMP. The rise in cAMP causes smooth‑muscle relaxation and vasodilation of the corpus cavernosum, which enhances arterial inflow and facilitates erection.

The dose of Muse is determined by the prescribing clinician based on the individual’s condition, response, and tolerability. The healthcare professional will select the appropriate strength and administration schedule, and patients should follow the prescriber’s instructions exactly.

Muse is indicated for adult males with erectile dysfunction and is not intended for use by women. There is insufficient data on its safety in pregnancy or lactation, and it should not be used by pregnant or breastfeeding individuals.

To order Muse, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any temperature control) and necessary import documentation.

Muse delivers alprostadil directly to the urethra, providing a rapid local effect without systemic exposure. Compared with oral phosphodiesterase‑5 inhibitors, Muse may be useful when oral agents are ineffective or contraindicated, but it requires proper insertion technique and may cause local discomfort.

Muse should be stored at room temperature, below 25 °C, in its original packaging. Keep the product away from moisture and direct sunlight. Do not freeze. Ensure the suppository remains dry until the time of administration.

Muse is inserted into the urethra using the supplied applicator. The patient typically administers the dose about 5–10 minutes before anticipated sexual activity. Detailed instructions for proper insertion are provided with the product and should be reviewed with a healthcare professional.

The most serious risks include priapism (an erection lasting longer than four hours) and severe hypotension, especially when used with nitrates or other vasodilators. An allergic reaction such as rash, swelling, or anaphylaxis can also occur and requires immediate medical attention.

Muse is contraindicated in patients with known hypersensitivity to alprostadil or any component of the formulation, those using nitrates, and individuals with severe penile anatomical abnormalities or active urethral infections. It should also be avoided in patients with unstable cardiovascular disease.