Product image of Muse (Alprostadil) supplied by GNH India

Muse

Active Ingredient:
Alprostadil
Origin:
EU

Muse (Alprostadil)

Alprostadil, the active ingredient in Muse, is a Prostaglandin E1 analog presented as a urethral suppository for urethral administration. It is indicated for the treatment of erectile dysfunction in adult males, promoting penile erection through direct vasodilation.

GNH India supplies Muse as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The product complies with European Union pharmacopeial standards and is manufactured under GMP conditions, ensuring safety and efficacy for patients.

Manufacturer / TM Owner

Viatris Sia

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Indications & Clinical Uses

Alprostadil is used to manage erectile dysfunction, a condition involving impaired penile blood flow.

  • Erectile dysfunction: facilitates erection in men with difficulty achieving sufficient rigidity.
  • Penile arterial insufficiency: improves penile blood flow in patients with arterial narrowing.
  • Post‑prostatectomy penile rehabilitation: aids recovery of erectile function after radical prostatectomy.

How It Works

  • Alprostadil binds to prostaglandin E1 receptors on penile smooth muscle, activating adenylate cyclase and increasing intracellular cyclic AMP. Elevated cAMP leads to relaxation of smooth muscle, vasodilation of penile arteries, and enhanced blood inflow, resulting in erection.

Side Effects

Alprostadil may cause a range of adverse reactions.

Common Side Effects

  • Urethral irritation: mild burning or discomfort at the site of insertion.
  • Penile pain: transient aching during or after administration.
  • Light bleeding: minor urethral spotting.
  • Headache: mild to moderate intensity.
  • Dizziness: occasional feeling of light‑headedness.
  • Nausea: occasional upset stomach.

Serious or Rare Side Effects

  • Priapism: prolonged erection lasting more than four hours, requiring urgent medical attention.
  • Severe hypotension: marked drop in blood pressure, especially if combined with nitrates.
  • Allergic reaction: rash, itching, swelling, or anaphylaxis.
  • Infection: urethral or penile infection at the application site.
  • Penile fibrosis: rare development of fibrous tissue in the penis.
  • Cardiovascular events: rare chest pain or arrhythmia.

Precautions & Warnings

Before using Muse, consider the following safety measures.

  • Assess cardiovascular status: ensure the patient can tolerate vasodilation without undue risk.
  • Avoid concurrent nitrate therapy: combined use may cause severe hypotension.
  • Screen for bleeding disorders: increased risk of urethral bleeding.
  • Monitor for priapism: seek immediate care if erection persists beyond four hours.
  • Contraindicated in severe penile anatomical abnormalities: avoid use in such cases.
  • Store at room temperature: keep in the original container, protect from moisture and heat.

Avoid Interactions

Alprostadil may interact with other medications; review patient medication lists.

Major Interactions (Avoid)

  • Nitrates: concurrent use can cause profound hypotension.
  • Alpha‑blockers: may amplify blood pressure‑lowering effects.
  • Severe antihypertensive agents: risk of excessive blood pressure drop.

Moderate Interactions (Monitor Closely)

  • PDE5 inhibitors (e.g., sildenafil): increased risk of priapism; monitor erection duration.
  • Anticoagulants: may enhance bleeding at the urethral site.
  • Antiplatelet agents: potential for increased urethral bleeding.

Frequently Asked Questions

Muse is a prescription urethral suppository containing alprostadil that is used to treat erectile dysfunction in adult males. It works by promoting blood flow to the penis, helping men achieve and maintain an erection sufficient for sexual activity.

Alprostadil is a prostaglandin E1 analog that binds to specific receptors on penile smooth muscle. This activates adenylate cyclase, raising intracellular cyclic AMP levels, which relaxes the smooth muscle, dilates penile arteries, and increases blood inflow to produce an erection.

The dose of Muse is individualized by a qualified prescriber based on the patient’s condition, response, and tolerability. The prescribing clinician determines the appropriate amount and frequency of administration; no standard dose is provided here.

Muse is not indicated for use in pregnant or breastfeeding individuals. Safety data are lacking for these populations, and the product is intended for adult males with erectile dysfunction. Physicians should weigh potential risks before prescribing.

To order Muse, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

The primary alternative class for erectile dysfunction is phosphodiesterase‑5 (PDE5) inhibitors such as sildenafil. Unlike oral PDE5 inhibitors, Muse is a locally administered urethral suppository that directly relaxes penile smooth muscle, offering an option for patients who cannot take oral agents or who need a rapid onset of action.

Muse should be stored at room temperature, below 25 °C, in its original packaging. Keep the product away from moisture, direct sunlight, and excessive heat. Do not freeze. Handle with clean, dry hands and avoid contaminating the suppository tip before insertion.

Muse is inserted into the urethra using the supplied applicator. The patient or a healthcare professional gently places the suppository into the distal urethra, typically 5–10 minutes before sexual activity. No oral ingestion is required, and the medication acts locally.

The most serious risks include priapism (an erection lasting more than four hours), severe hypotension especially when combined with nitrates or other vasodilators, and allergic reactions that may progress to anaphylaxis. Prompt medical attention is required if any of these events occur.

Muse is contraindicated in patients using nitrate medications, those with severe cardiovascular disease, uncontrolled hypertension, or significant penile anatomical abnormalities. It should also be avoided in individuals with known hypersensitivity to alprostadil or any component of the formulation.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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