Product image of Muse (Alprostadil) supplied by GNH India

Muse

Active Ingredient:
Alprostadil
Origin:
EU

Muse (Alprostadil)

Alprostadil, the active ingredient in Muse, is a prostaglandin E1 analog presented as a urethral formulation for use in the treatment of erectile dysfunction in adult males. It promotes smooth‑muscle relaxation and increased blood flow to the penis, facilitating an erection suitable for sexual activity. The medication is administered directly into the urethra under medical supervision.

GNH India supplies Muse as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, with a focus on quality assurance and timely delivery.

Manufacturer / TM Owner

Viatris Sia

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Indications & Clinical Uses

Alprostadil is used in the management of erectile dysfunction, a condition affecting the ability to achieve or maintain an erection.

  • Erectile dysfunction: facilitates erection by increasing blood flow to the corpus cavernosum.
  • Penile rehabilitation after radical prostatectomy: may aid recovery of erectile function during postoperative healing.
  • Male sexual dysfunction of vascular origin: improves erectile response in men with compromised penile blood flow.

How It Works

  • Alprostadil (prostaglandin E1) binds to prostaglandin receptors on smooth‑muscle cells of the corpus cavernosum, activating adenylate cyclase and raising intracellular cyclic AMP levels. Elevated cAMP leads to smooth‑muscle relaxation, vasodilation, and increased arterial inflow, which together produce an erection suitable for sexual activity.

Side Effects

Alprostadil may cause a range of adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Urethral burning or discomfort
  • Mild penile pain
  • Transient headache
  • Flushing
  • Nausea

Serious or Rare Side Effects

  • Priapism (prolonged erection)
  • Severe hypotension
  • Allergic reaction (rash, swelling, anaphylaxis)
  • Penile fibrosis
  • Infection at the administration site

Precautions & Warnings

Before prescribing Muse, clinicians should consider several safety measures.

  • Medical evaluation: confirm diagnosis of erectile dysfunction before use.
  • Contraindications: avoid in patients with known hypersensitivity to alprostadil.
  • Cardiovascular risk: assess for severe coronary artery disease prior to administration.
  • Concurrent anticoagulant therapy: monitor for increased bleeding risk.
  • Avoid use in patients with sickle cell disease or severe anemia.
  • Store below 25°C: keep in original packaging, protect from moisture.

Avoid Interactions

Alprostadil can interact with other medicines, requiring attention to avoid harmful effects.

Major Interactions (Avoid)

  • Nitrates: concurrent use may cause severe hypotension.
  • Alpha‑blockers: risk of additive blood pressure lowering.
  • Sildenafil and other PDE5 inhibitors: may increase risk of priapism.

Moderate Interactions (Monitor Closely)

  • Anticoagulants (warfarin, DOACs): monitor for bleeding.
  • Antihypertensives: may enhance blood pressure effects.
  • Alcohol: may increase dizziness.

Frequently Asked Questions

Muse is a prescription medication that contains alprostadil and is used to treat erectile dysfunction in adult men. It is administered directly into the urethra to promote an erection by increasing blood flow to the penis.

Alprostadil is a prostaglandin E1 analog that binds to specific receptors on penile smooth‑muscle cells, raising intracellular cyclic AMP. The rise in cAMP causes smooth‑muscle relaxation and vasodilation, allowing more blood to fill the corpus cavernosum and produce an erection.

The dose of Muse is individualized. A qualified prescriber determines the appropriate amount, concentration, and frequency based on the patient’s condition, response, and any relevant medical factors.

Safety of alprostadil in pregnancy or while breastfeeding has not been established. The product is generally not recommended for use by pregnant or nursing women, and it should only be prescribed when the potential benefit outweighs any possible risk.

To order Muse, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and import documentation.

The primary alternative class for erectile dysfunction is phosphodiesterase‑5 (PDE5) inhibitors such as sildenafil. Unlike oral PDE5 inhibitors, Muse is a urethral formulation that acts locally and does not require systemic absorption, making it useful for patients who cannot take oral agents or who need a rapid onset of action.

Muse should be stored below 25 °C in its original packaging, protected from moisture and direct sunlight. Keep the product out of reach of children and do not use it after the expiration date indicated on the label.

Muse is administered by a healthcare professional who inserts a small dose of the urethral solution into the urethra using a specialized applicator. The medication is absorbed locally, and an erection typically develops within a few minutes if the patient is sexually stimulated.

The most serious adverse events associated with Muse include priapism (an erection lasting longer than four hours), severe hypotension, and allergic reactions that may present as rash, swelling, or anaphylaxis. Patients should seek immediate medical attention if any of these symptoms occur.

Muse should not be used by individuals with known hypersensitivity to alprostadil, those with severe coronary artery disease, patients taking nitrates or certain alpha‑blockers, men with sickle cell disease, severe anemia, or any condition that makes a prolonged erection dangerous.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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