Muse (Alprostadil)

Alprostadil activates prostaglandin E1 receptors in the smooth muscle of the corpus cavernosum, raising intracellular cAMP. The rise in cAMP causes smooth‑muscle relaxation and vasodilation, increasing blood flow into the penile tissue and facilitating erection.

The prescribed dose of Muse is determined by the treating physician based on the individual’s medical condition and response. The product is supplied as a 125 µg urethral suppository, and the prescriber decides the frequency and timing of administration.

Muse is intended for use in adult males with erectile dysfunction. Its safety in pregnancy or breastfeeding has not been established, and it is not indicated for use by women. Women who are pregnant, planning pregnancy, or nursing should avoid handling the product without appropriate protective measures.

To order Muse, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and assistance with import documentation.

Muse delivers alprostadil directly to the urethra, offering a local route that bypasses oral absorption. This can be advantageous for patients who cannot take oral phosphodiesterase‑5 inhibitors or who experience inadequate response. Compared with injectable alprostadil, Muse is less invasive but may have a higher incidence of urethral irritation.

Muse should be stored at room temperature, below 25 °C. Keep the suppositories in their original packaging, protect them from moisture and direct light, and avoid exposure to extreme temperatures to maintain product stability.

Muse is inserted into the urethra using the supplied applicator. The patient should follow the prescriber’s instructions, typically inserting the suppository shortly before anticipated sexual activity. No additional preparation is required, but the area should be clean before administration.

The most serious risks include priapism (a prolonged erection lasting more than four hours) and severe hypotension. If either occurs, immediate medical attention is required. Rarely, an allergic reaction such as rash, swelling, or anaphylaxis may develop.

Muse should not be used by men with known hypersensitivity to alprostadil or any excipients, those with severe cardiovascular disease such as recent myocardial infarction, uncontrolled hypertension, or who are taking nitrates. It is also contraindicated in patients with active urethral infections or severe bleeding disorders.