Muse (Alprostadil)

Alprostadil is a prostaglandin E1 analogue that activates adenylate cyclase in the smooth muscle of the corpus cavernosum, raising intracellular cyclic AMP. The rise in cAMP causes smooth‑muscle relaxation and vasodilation, which enhances arterial inflow and engorgement of the penis, facilitating erection when sexual stimulation occurs.

The prescribed dose of Muse is determined by the treating physician based on the individual’s health status, severity of erectile dysfunction, and response to therapy. The product is supplied as a 125 µg urethral suppository, and the prescriber decides the timing and frequency of administration.

Safety of alprostadil, including Muse, has not been established in pregnant or breastfeeding individuals. Because the product is intended for adult male erectile dysfunction, it is generally not recommended for use by women who are pregnant, planning pregnancy, or nursing. Consultation with a healthcare professional is essential.

To order Muse, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide. After the request, the sales team will verify trade or institutional credentials and respond with pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Muse delivers alprostadil directly to the urethra, providing rapid onset without the systemic exposure associated with oral phosphodiesterase‑5 inhibitors. Oral agents require sexual stimulation and have a longer onset time, while Muse can be used shortly before activity. Choice of therapy depends on patient preference, contraindications, and response to previous treatments.

Muse should be stored at room temperature, below 25 °C, in its original packaging to protect it from moisture and direct sunlight. Keep the product out of reach of children and avoid exposing it to extreme heat or humidity, which could affect the suppository’s integrity.

Muse is inserted into the urethral meatus using the supplied applicator. The patient typically administers the 125 µg suppository shortly before anticipated sexual activity, allowing the drug to dissolve and be absorbed through the urethral mucosa, leading to erection within minutes.

The most serious risks include priapism lasting longer than four hours, which requires immediate medical attention, and severe hypotension that can cause fainting or shock. Allergic reactions such as rash, swelling, or difficulty breathing are also critical and should be reported promptly.

Muse is contraindicated in men who are allergic to alprostadil or any component of the formulation, those using nitrate medications, and patients with severe cardiovascular disease that precludes sexual activity. Individuals with bleeding disorders or urethral abnormalities should also avoid use unless cleared by a physician.