Product image of Mutabon Antidepressivo (Amitriptyline Hydrochloride, Perphenazine) supplied by GNH India

Mutabon Antidepressivo

Active Ingredient:
Amitriptyline Hydrochloride, Perphenazine
Origin:
EU

Mutabon Antidepressivo (Amitriptyline Hydrochloride, Perphenazine)

Amitriptyline Hydrochloride / Perphenazine, the active ingredient in Mutabon Antidepressivo, is a combination antidepressant and typical antipsychotic presented as an oral tablet for oral use. It is indicated for the treatment of depression in adult patients, including depressive episodes with psychotic features and is prescribed by psychiatrists and primary care physicians.

GNH India supplies Mutabon Antidepressivo as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory‑approved batches to meet global demand.

Manufacturer / TM Owner

Neopharmed Gentili Spa

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Indications & Clinical Uses

Mutabon Antidepressivo combines amitriptyline and perphenazine to address depressive disorders and associated psychotic symptoms.

  • Major depressive disorder: reduces depressive symptoms and improves mood in adult patients.
  • Psychotic depression: alleviates depressive symptoms while controlling psychotic features.
  • Treatment‑resistant depression: provides an alternative when monotherapy has been insufficient.
  • Severe depressive episodes with agitation: helps stabilize mood and reduce agitation.
  • Depressive episodes with insomnia: amitriptyline component improves sleep quality.

How It Works

  • Amitriptyline hydrochloride blocks the reuptake of norepinephrine and serotonin, increasing their synaptic concentrations and enhancing mood‑regulating pathways. Perphenazine antagonizes dopamine D2 receptors, reducing dopaminergic transmission that contributes to psychotic symptoms. The combined actions provide both antidepressant and antipsychotic effects, addressing mood disturbances and psychosis concurrently. These mechanisms synergize to improve overall psychiatric stability and may reduce the need for separate medications.

Side Effects

Mutabon Antidepressivo may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Drowsiness: feeling of sleepiness or reduced alertness.
  • Dry mouth: decreased salivation leading to discomfort.
  • Constipation: slowed gastrointestinal transit.
  • Weight gain: increase in body weight over time.
  • Blurred vision: temporary visual disturbances.
  • Orthostatic hypotension: dizziness upon standing.

Serious or Rare Side Effects

  • Cardiac arrhythmia: irregular heart rhythm that may be life‑threatening.
  • Neuroleptic malignant syndrome: rare but severe reaction with fever and muscle rigidity.
  • Seizures: risk of convulsive episodes, especially at high doses.
  • Severe hypotension: marked drop in blood pressure causing fainting.
  • Agranulocytosis: dangerously low white blood cell count.
  • Hepatotoxicity: liver injury indicated by elevated enzymes.

Precautions & Warnings

Before prescribing Mutabon Antidepressivo, clinicians should consider several safety precautions.

  • Pregnancy: Category C; use only if potential benefits justify the risk.
  • Breastfeeding: caution advised as drug may be excreted in milk.
  • Elderly patients: start with low dose and monitor for anticholinergic effects.
  • Cardiac history: avoid in patients with known conduction disorders or recent myocardial infarction.
  • Concomitant CNS depressants: monitor for enhanced sedation and respiratory depression.
  • Storage: Store below 25°C: keep in original container, protect from moisture and light.

Avoid Interactions

Mutabon Antidepressivo can interact with other medicines, altering efficacy or safety.

Major Interactions (Avoid)

  • MAO inhibitors: risk of severe hypertensive crisis; must be discontinued at least 14 days prior.
  • CYP2D6 inhibitors (e.g., fluoxetine, paroxetine): can increase amitriptyline levels leading to toxicity.

Moderate Interactions (Monitor Closely)

  • Anticholinergic drugs: additive dry mouth, constipation, urinary retention.
  • CNS depressants (alcohol, benzodiazepines): enhanced sedation and respiratory depression.
  • QT‑prolonging agents: combined effect may increase risk of cardiac arrhythmias.

Frequently Asked Questions

Mutabon Antidepressivo is a prescription oral tablet that combines amitriptyline and perphenazine. It is used to treat major depressive disorder, including depressive episodes that present with psychotic features, and may be considered when single‑agent therapy is insufficient.

Amitriptyline is a tricyclic antidepressant that inhibits the reuptake of norepinephrine and serotonin, raising their levels in the brain. This enhances neurotransmission in pathways that regulate mood, helping to alleviate depressive symptoms.

The appropriate dose is individualized by the prescribing clinician based on the patient’s clinical condition, response, age, and any co‑existing medical issues. No fixed dosing regimen is provided here; the prescriber sets the regimen.

The product is classified as Pregnancy Category C, indicating that risk cannot be ruled out and it should be used only if the potential benefit justifies the potential fetal risk. It is excreted in breast milk, so caution is advised for nursing mothers.

Enquiries are submitted via the product page on gnhindia.com, where you specify the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Compared with using amitriptyline alone, Mutabon adds perphenazine to address psychotic symptoms, potentially reducing the need for a separate antipsychotic. Relative to other combination products, it offers a single‑tablet regimen that simplifies dosing but shares similar safety considerations.

Store the tablets at temperatures below 25 °C in the original packaging. Protect them from moisture, direct sunlight and extreme heat. Keep the container tightly closed and out of reach of children.

Mutabon Antidepressivo is taken orally, usually with a full glass of water. It may be taken with or without food, but patients should follow the prescriber’s instructions regarding timing and any dietary considerations.

Serious risks include cardiac arrhythmias, neuroleptic malignant syndrome, seizures, severe hypotension, agranulocytosis, and hepatotoxicity. Patients should be monitored for signs such as irregular heartbeat, high fever, muscle rigidity, unexplained weakness, or abnormal liver function tests.

Contraindications include patients with known hypersensitivity to amitriptyline, perphenazine, or any component of the formulation, those with recent myocardial infarction or significant conduction disorders, and individuals taking monoamine oxidase inhibitors within the past 14 days.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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