Product image of Mutabon Mite (Amitriptyline Hydrochloride, Perphenazine) supplied by GNH India

Mutabon Mite

Active Ingredient:
Amitriptyline Hydrochloride, Perphenazine
Origin:
EU

Mutabon Mite (Amitriptyline Hydrochloride, Perphenazine)

Amitriptyline Hydrochloride, the active ingredient in Mutabon Mite, is a Combination (Tricyclic Antidepressant + Phenothiazine Antipsychotic) presented as an oral combination tablet for oral use. It treats major depressive disorder, anxiety disorders, schizophrenia and other psychotic disorders in adults.

GNH India supplies Mutabon Mite as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Neopharmed Gentili Spa

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Indications & Clinical Uses

Mutabon Mite is a combination antidepressant‑antipsychotic that acts on mood and psychotic pathways. It is indicated for several psychiatric conditions:

  • Major depressive disorder: alleviates depressive symptoms and improves mood.
  • Anxiety disorders: reduces excessive anxiety and associated physical tension.
  • Schizophrenia: controls psychotic symptoms such as hallucinations and delusions.
  • Other psychotic disorders: improves overall psychotic symptomatology.

How It Works

  • Amitriptyline inhibits the reuptake of norepinephrine and serotonin, raising their synaptic concentrations, while Perphenazine blocks dopamine D2 receptors and other neurotransmitter sites, decreasing dopaminergic transmission. The combined effect modulates mood, anxiety and psychotic pathways, providing both antidepressant and antipsychotic activity.

Side Effects

Adverse reactions may occur with any psychiatric medication. Common side effects are usually mild and transient.

Common Side Effects

  • Dry mouth: reduced salivary flow causing discomfort.
  • Drowsiness: increased sedation, especially after dose initiation.
  • Constipation: slowed gastrointestinal motility.
  • Weight gain: gradual increase in body weight.

Serious or Rare Side Effects

  • Neuroleptic malignant syndrome: life‑threatening reaction with fever and muscle rigidity.
  • Agranulocytosis: severe reduction in white blood cells.
  • Cardiac arrhythmia: abnormal heart rhythm, particularly in patients with pre‑existing heart disease.

Precautions & Warnings

Before prescribing Mutabon Mite, clinicians should consider several safety measures.

  • Cardiac monitoring: assess patients with known heart disease for arrhythmia risk.
  • Suicidal ideation: monitor especially during early treatment phases.
  • Liver function: evaluate hepatic status and adjust if impaired.
  • Abrupt discontinuation: taper dose under medical supervision to avoid withdrawal.
  • Store at ambient temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Mutabon Mite can interact with a range of medicines; some combinations should be avoided.

Major Interactions (Avoid)

  • MAO inhibitors: risk of hypertensive crisis.
  • SSRIs or other serotonergic agents: potential serotonin syndrome.
  • Other anticholinergics: increased anticholinergic burden.
  • CNS depressants: enhanced sedation and respiratory depression.
  • QT‑prolonging drugs: heightened risk of cardiac arrhythmia.

Moderate Interactions (Monitor Closely)

  • CYP2D6 inhibitors: may increase amitriptyline levels.
  • Antihypertensives: additive blood‑pressure lowering effect.
  • Antidiabetic agents: possible alteration of glucose control.
  • Alcohol: increased sedation and dizziness.
  • Antihistamines: enhanced anticholinergic side effects.

Frequently Asked Questions

Mutabon Mite is prescribed for major depressive disorder, anxiety disorders, schizophrenia and other psychotic disorders. It combines an antidepressant and an antipsychotic to address both mood and psychotic symptoms in adult patients.

Amitriptyline Hydrochloride blocks the reuptake of norepinephrine and serotonin, increasing their levels in the brain. This enhances mood and reduces anxiety, complementing Perphenazine’s antipsychotic action to provide a broader therapeutic effect.

The specific dose of Mutabon Mite is determined by the treating physician based on the individual’s clinical condition, age, weight and response to therapy. Only a qualified prescriber should set the dosage regimen.

Safety data for Mutabon Mite in pregnancy and lactation are limited. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and the decision must be made by a healthcare professional.

To request Mutabon Mite, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Mutabon Mite combines two active agents in a single tablet, potentially simplifying regimens compared with prescribing separate antidepressant and antipsychotic medications. This may improve adherence but requires careful monitoring for combined side‑effect profiles and drug interactions.

Mutabon Mite should be stored at ambient temperature, below 25 °C, in its original packaging. Keep the product away from moisture and direct sunlight to maintain stability and potency.

Mutabon Mite is taken orally, usually with water. The tablet should be swallowed whole and not crushed or chewed unless otherwise directed by a healthcare professional.

Serious risks include neuroleptic malignant syndrome, agranulocytosis, and cardiac arrhythmias. Patients should be monitored for fever, muscle rigidity, signs of infection, or irregular heartbeats, and any concerning symptoms should prompt immediate medical evaluation.

Mutabon Mite is contraindicated in patients with known hypersensitivity to amitriptyline, perphenazine, or any component of the formulation, as well as in individuals taking monoamine oxidase inhibitors within the past 14 days. Caution is also advised for patients with severe cardiac, hepatic or renal impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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