Product image of Mutaflor (Escherichia Coli Strain Nissle 1917) supplied by GNH India

Mutaflor

Active Ingredient:
Escherichia Coli Strain Nissle 1917
Origin:
EU

Mutaflor (Escherichia Coli Strain Nissle 1917)

Escherichia coli Nissle 1917, the active ingredient in Mutaflor, is a probiotic presented as a capsule for oral use. It is employed to support gastrointestinal health and is indicated for maintenance therapy in ulcerative colitis and other inflammatory bowel conditions.

GNH India supplies Mutaflor as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Ardeypharm Gmbh

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Indications & Clinical Uses

Mutaflor is a probiotic that acts on the gastrointestinal microbiota and is employed in several chronic intestinal disorders.

  • Ulcerative colitis: helps maintain remission and reduces flare‑ups.
  • Inflammatory bowel disease: may lower disease activity and support mucosal healing.
  • Irritable bowel syndrome: can improve abdominal discomfort and bowel habit regularity.

How It Works

  • Mutaflor delivers live Escherichia coli Nissle 1917 to the intestinal lumen where it competes with pathogenic bacteria for adhesion sites, produces antimicrobial substances, strengthens the mucosal barrier, and modulates local immune responses, thereby helping to restore a balanced gut microbiota.

Side Effects

Adverse reactions are generally mild and related to gastrointestinal tolerance.

Common Side Effects

  • Mild abdominal discomfort
  • Flatulence or bloating
  • Nausea
  • Diarrhea
  • Headache
  • Transient constipation

Serious or Rare Side Effects

  • Bacteremia or sepsis, particularly in immunocompromised patients
  • Severe allergic reaction (anaphylaxis, rash, swelling)
  • Persistent fever
  • Unexplained weight loss
  • Severe abdominal pain

Precautions & Warnings

Before initiating Mutaflor, consider patient‑specific factors and monitor for potential risks.

  • Assess immune status: use with caution in immunocompromised individuals.
  • Review infection history: avoid in patients with recent systemic infections.
  • Evaluate hypersensitivity: discontinue if allergic reactions occur.
  • Monitor pediatric use: safety data are limited in children.
  • Store at ambient temperature: keep in the original pack, protect from moisture.

Avoid Interactions

Mutaflor may interact with other agents that affect gut flora or immune function.

Major Interactions (Avoid)

  • Broad‑spectrum antibiotics: can eradicate the probiotic strain and diminish efficacy.
  • Systemic immunosuppressants: increase risk of opportunistic infection.

Moderate Interactions (Monitor Closely)

  • Proton‑pump inhibitors: may alter gastric pH and affect bacterial survival.
  • Antacids containing aluminum or magnesium: could impact colonisation.
  • Concurrent probiotic products: potential competition for intestinal niches.

Frequently Asked Questions

Mutaflor is prescribed as a probiotic to help maintain remission in ulcerative colitis, to support treatment of inflammatory bowel disease, and to alleviate symptoms of irritable bowel syndrome by modulating the intestinal microbiota.

The live strain Escherichia coli Nissle 1917 colonises the gut, competes with harmful bacteria for adhesion sites, produces antimicrobial compounds, reinforces the mucosal barrier and influences local immune pathways, thereby promoting a healthier microbial balance.

The appropriate dose of Mutaflor is determined by the prescribing clinician based on the individual’s condition, severity, and treatment goals. Patients should follow the specific instructions provided by their healthcare professional.

Safety data for Mutaflor in pregnancy and lactation are limited. Healthcare providers should weigh potential benefits against unknown risks before prescribing it to pregnant or nursing individuals.

To request Mutaflor, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Mutaflor contains a single, well‑studied strain (E. coli Nissle 1917) with documented efficacy in ulcerative colitis, whereas many other probiotics use mixed‑culture formulations. Clinical evidence for Mutaflor’s specific indications is generally stronger for maintenance therapy in ulcerative colitis.

Mutaflor capsules should be stored at ambient temperature, below 25 °C, in the original packaging to protect them from moisture and excessive heat. Do not refrigerate or freeze the product.

Mutaflor is taken orally as a capsule. The capsule should be swallowed whole with water, preferably on an empty stomach or as directed by the prescribing clinician.

The most serious risks include rare cases of bacteremia or sepsis, especially in immunocompromised patients, and severe allergic reactions such as anaphylaxis. Prompt medical attention is required if these symptoms occur.

Mutaflor should be avoided in individuals with known hypersensitivity to Escherichia coli Nissle 1917, those with severe immunosuppression, or patients with active systemic infections unless specifically advised by a healthcare professional.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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