Product image of Mutaflor (Escherichia Coli Strain Nissle 1917) supplied by GNH India

Mutaflor

Active Ingredient:
Escherichia Coli Strain Nissle 1917
Origin:
EU

Mutaflor (Escherichia Coli Strain Nissle 1917)

Escherichia coli Nissle 1917, the active ingredient in Mutaflor, is a live bacterial preparation presented as an oral probiotic formulation. It is employed to help maintain remission in individuals with ulcerative colitis by supporting a balanced intestinal microbiota.

GNH India supplies Mutaflor as a licensed, GDP‑compliant international pharmaceutical supplier, providing the product to hospitals, pharmacies and clinics worldwide. The product originates from the European Union market and meets stringent regulatory requirements.

Manufacturer / TM Owner

Ardeypharm Gmbh

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Indications & Clinical Uses

Mutaflor is a probiotic that acts on the gastrointestinal microbiota to support ulcerative colitis management.

  • Ulcerative colitis: helps maintain remission in patients with ulcerative colitis.

How It Works

  • Mutaflor delivers viable Escherichia coli Nissle 1917 to the gut, where it competes with pathogenic bacteria, reinforces the mucosal barrier, and modulates immune signaling pathways. The strain promotes production of anti‑inflammatory cytokines and restores microbial diversity, thereby contributing to intestinal homeostasis and reducing relapse risk in ulcerative colitis.

Side Effects

Adverse reactions are generally mild and gastrointestinal in nature.

Common Side Effects

  • Abdominal discomfort: mild pain or cramping.
  • Flatulence: increased gas production.
  • Bloating: sensation of abdominal fullness.
  • Diarrhea: loose stools occurring intermittently.
  • Nausea: occasional feeling of queasiness.
  • Headache: transient mild headache.

Serious or Rare Side Effects

  • Bacteremia: presence of bacteria in the bloodstream, reported rarely.
  • Sepsis: systemic infection in immunocompromised individuals.
  • Allergic reaction: rash, itching, or swelling.
  • Anaphylaxis: severe, life‑threatening hypersensitivity.
  • Persistent fever: unexplained elevated temperature.
  • Severe abdominal pain: intense, prolonged pain requiring medical evaluation.

Precautions & Warnings

Safety considerations should be reviewed before initiating therapy.

  • Assess immune status: evaluate for severe immunodeficiency before use.
  • Monitor gastrointestinal symptoms: watch for worsening abdominal pain or diarrhea.
  • Avoid in severe immunocompromise: contraindicated in patients with profound neutropenia.
  • Pregnancy and lactation: safety not established; use only if clearly needed.
  • Discontinue if infection occurs: stop product if systemic infection develops.
  • Store at room temperature: keep in the original pack, protect from moisture and direct sunlight.

Avoid Interactions

Potential interactions with other medicines should be considered.

Major Interactions (Avoid)

  • Antibiotics: may reduce probiotic viability; avoid concurrent administration.
  • Immunosuppressants: increased risk of infection; avoid simultaneous use.
  • Live bacterial vaccines: possible interference with vaccine efficacy.

Moderate Interactions (Monitor Closely)

  • Antacids: may alter gastric pH and affect bacterial survival.
  • Corticosteroids: monitor for signs of infection.
  • Chemotherapy agents: observe for opportunistic infections.

Frequently Asked Questions

Mutaflor is a probiotic containing the live bacterial strain Escherichia coli Nissle 1917. It is primarily used to help maintain remission in patients with ulcerative colitis by supporting a balanced gut microbiota.

The strain colonises the intestinal lumen, competes with pathogenic microbes, strengthens the mucosal barrier and modulates immune responses. This multifaceted action helps restore microbial equilibrium and reduces inflammatory activity associated with ulcerative colitis.

The dosage of Mutaflor is determined by the prescribing healthcare professional based on the patient’s condition and clinical guidelines. Patients should follow the prescriber’s instructions and not alter the dose without medical advice.

Safety data for Mutaflor in pregnancy and lactation are limited. It should only be used if the potential benefit justifies any possible risk, and the decision must be made by a qualified healthcare provider.

To order Mutaflor, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Unlike conventional anti‑inflammatory drugs, Mutaflor is a probiotic that targets gut microbiota rather than directly suppressing immune pathways. It is often used as an adjunct to standard therapy for maintaining remission, whereas other agents such as mesalamine or biologics act on inflammatory mediators.

Mutaflor should be stored at room temperature, below 25 °C, in its original packaging. Protect the product from moisture and direct sunlight to maintain bacterial viability.

Mutaflor is taken orally, usually as a capsule or sachet containing the live bacterial preparation. It should be swallowed with water according to the prescriber’s directions, and may be taken with or without food depending on clinical advice.

Serious risks, though rare, include bacteremia, sepsis, and severe allergic reactions such as anaphylaxis. These events are more likely in patients with compromised immune systems, and prompt medical attention is required if they occur.

Mutaflor is contraindicated in individuals with severe immunodeficiency, uncontrolled systemic infection, or known hypersensitivity to the product. Patients with these conditions should avoid use and discuss alternative therapies with their healthcare provider.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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