Product image of Mycomax (Fluconazole) supplied by GNH India

Mycomax

Active Ingredient:
Fluconazole
Origin:
EU

Mycomax (Fluconazole)

Fluconazole, the active ingredient in Mycomax, is an azole antifungal presented as an oral dosage for systemic use. It treats a range of fungal infections, including candidiasis and cryptococcal disease, in adult and pediatric patients as prescribed by a healthcare professional.

GNH India supplies Mycomax as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Zentiva, K.S.

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Indications & Clinical Uses

Fluconazole acts on fungal infections by inhibiting ergosterol synthesis, making it effective for several Candida and Cryptococcus species.

  • Candidiasis: resolves mucosal and systemic Candida infections, including oropharyngeal, esophageal and vaginal forms.
  • Cryptococcal meningitis: treats systemic cryptococcal infections, particularly in immunocompromised patients.
  • Prophylaxis in immunocompromised patients: prevents opportunistic fungal infections during chemotherapy or organ transplantation.

How It Works

  • Fluconazole inhibits the fungal cytochrome P450 enzyme 14α‑demethylase, a key step in ergosterol biosynthesis. By blocking this enzyme, the drug disrupts cell membrane formation, leading to increased membrane permeability and inhibition of fungal growth and replication.

Side Effects

Fluconazole may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Nausea: mild to moderate gastrointestinal upset.
  • Headache: transient cranial discomfort.
  • Rash: skin erythema or pruritus.
  • Diarrhea: loose stools, usually self‑limiting.
  • Abdominal pain: cramping or discomfort.
  • Taste alteration: dysgeusia or metallic taste.

Serious or Rare Side Effects

  • Hepatotoxicity: elevated liver enzymes or liver injury.
  • Severe skin reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Anaphylaxis: acute hypersensitivity with respiratory compromise.
  • QT prolongation: cardiac rhythm disturbances.
  • Hepatic failure: rare but life‑threatening liver dysfunction.
  • Severe liver enzyme elevation: marked transaminase rise requiring monitoring.

Precautions & Warnings

Fluconazole should be used with careful clinical assessment and monitoring.

  • Liver function monitoring: assess baseline enzymes and repeat during therapy.
  • Renal impairment adjustment: dose may need modification in severe kidney disease.
  • Drug interaction vigilance: review concomitant medications for CYP interactions.
  • Hypersensitivity avoidance: discontinue if allergic reactions occur.
  • Pregnancy and lactation: use only if benefits outweigh potential risks.
  • Store at below 25°C: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Fluconazole interacts with several drug classes; awareness of interaction severity guides clinical decisions.

Major Interactions (Avoid)

  • CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): may cause toxic fluconazole levels.
  • QT‑prolonging agents (e.g., cisapride, quinidine): increase risk of cardiac arrhythmia.
  • Warfarin: potentiates anticoagulant effect, raising INR.

Moderate Interactions (Monitor Closely)

  • Oral contraceptives: reduced efficacy, consider alternative contraception.
  • Antacids containing aluminum or magnesium: may decrease fluconazole absorption.
  • Rifampin: induces metabolism, lowering fluconazole concentrations.
  • Statins (e.g., simvastatin): increased risk of myopathy, monitor muscle symptoms.
  • Phenytoin: may reduce fluconazole levels, adjust dosing if needed.

Frequently Asked Questions

Mycomax, containing fluconazole, is prescribed for a variety of fungal infections such as candidiasis of the mouth, throat, esophagus, vagina and bloodstream, as well as cryptococcal meningitis and other systemic cryptococcal infections. It may also be used for prophylaxis in patients with weakened immune systems.

Fluconazole blocks the fungal enzyme 14α‑demethylase, which is essential for converting lanosterol to ergosterol, a key component of the fungal cell membrane. By inhibiting this step, the drug compromises membrane integrity, halting fungal growth and allowing the immune system to clear the infection.

The dosage of Mycomax is individualized by the prescribing clinician based on the type and severity of the infection, patient age, weight, renal and hepatic function, and other clinical factors. Patients should follow the exact regimen provided by their healthcare professional.

The safety of fluconazole in pregnancy and lactation is not fully established. It should only be used if the potential benefit justifies any possible risk to the fetus or infant, and this decision must be made by a qualified healthcare provider.

To request Mycomax, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with other azole antifungals, fluconazole offers excellent oral bioavailability and a relatively favorable safety profile, making it suitable for both outpatient and inpatient settings. It is less potent than newer agents like voriconazole for certain invasive molds but remains first‑line for many Candida and Cryptococcus infections.

Mycomax should be stored at temperatures below 25 °C, in its original packaging, protected from moisture and direct sunlight. Maintaining these conditions helps preserve the tablet’s stability and potency throughout its shelf life.

Mycomax is taken orally, usually with or without food, as directed by the prescriber. The tablet should be swallowed whole with a full glass of water and not chewed or crushed unless specifically instructed.

Serious risks include liver injury, severe skin reactions such as Stevens‑Johnson syndrome, and cardiac arrhythmias due to QT prolongation. Patients should be monitored for signs of hepatic dysfunction, rash, or abnormal heart rhythms, and the drug should be stopped immediately if these occur.

Mycomax is contraindicated in individuals with known hypersensitivity to fluconazole or any other azole antifungal. Caution is also advised for patients with severe liver disease, significant QT prolongation, or those taking medications that have major interactions with fluconazole.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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