Product image of Mycophenolate Mofetil Teva (Mycophenolate Mofetil) supplied by GNH India

Mycophenolate Mofetil Teva

Active Ingredient:
Mycophenolate Mofetil
Origin:
EU

Mycophenolate Mofetil Teva (Mycophenolate Mofetil)

Mycophenolate Mofetil, the active ingredient in Mycophenolate Mofetil Teva, is an immunosuppressant presented as an oral formulation for oral use. It belongs to the antimetabolite class and is employed to prevent organ transplant rejection and to treat lupus nephritis in adult patients.

GNH India supplies Mycophenolate Mofetil Teva as a licensed, GDP‑compliant international pharmaceutical supplier, providing the product to hospitals, transplant centres, oncology units and pharmacies worldwide, with support for regulatory and logistics requirements and ensuring timely delivery to meet patient needs.

Manufacturer / TM Owner

Teva B.V

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Indications & Clinical Uses

Mycophenolate Mofetil is an antimetabolite immunosuppressant used in conditions requiring inhibition of the immune response.

  • Organ transplant rejection: prevents acute and chronic rejection in kidney, heart and liver transplants.
  • Lupus nephritis: reduces proteinuria and preserves renal function in systemic lupus erythematosus affecting the kidneys.
  • Graft‑versus‑host disease prophylaxis: used as part of combination therapy to reduce incidence of GVHD after hematopoietic stem cell transplantation.

How It Works

  • Mycophenolate Mofetil is a pro‑drug that is converted to mycophenolic acid, which selectively inhibits inosine monophosphate dehydrogenase (IMPDH). By blocking IMPDH, the synthesis of guanosine nucleotides is reduced, limiting DNA replication in activated T and B lymphocytes. This selective suppression of lymphocyte proliferation diminishes the immune response responsible for graft rejection and autoimmune kidney injury. The effect is reversible and primarily impacts rapidly dividing immune cells while sparing most other tissues.

Side Effects

Mycophenolate Mofetil may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Diarrhea: frequent loose stools.
  • Vomiting: occasional emesis.
  • Abdominal pain: cramping or discomfort.
  • Headache: transient head pain.
  • Upper respiratory infections: mild colds or sinusitis.

Serious or Rare Side Effects

  • Neutropenia: dangerously low white blood cell count.
  • Anemia: reduced red blood cell production.
  • Lymphopenia: decreased lymphocyte numbers.
  • Severe infections: opportunistic bacterial, viral or fungal infections.
  • Hepatic toxicity: elevated liver enzymes or hepatitis.
  • Malignancy risk: increased incidence of certain cancers with long‑term use.

Precautions & Warnings

When prescribing Mycophenolate Mofetil, clinicians should consider several safety measures.

  • Monitor blood counts: regular CBC to detect cytopenias.
  • Assess renal function: adjust dose if impaired.
  • Screen for infections: evaluate for opportunistic infections before and during therapy.
  • Avoid pregnancy: drug may be teratogenic; use effective contraception.
  • Store at ambient temperature: keep below 25°C, protect from moisture and light in original container.

Avoid Interactions

Mycophenolate Mofetil interacts with several medicines that may alter its efficacy or safety.

Major Interactions (Avoid)

  • Cyclosporine: increased mycophenolate exposure, monitor levels.
  • Tacrolimus: may increase risk of nephrotoxicity.
  • Antacids containing aluminum or magnesium: reduce absorption, separate dosing.

Moderate Interactions (Monitor Closely)

  • Azathioprine: additive bone marrow suppression.
  • Live vaccines: reduced efficacy, avoid administration.
  • Rifampin: may decrease mycophenolate plasma concentrations.

Frequently Asked Questions

Mycophenolate Mofetil Teva is an immunosuppressant indicated to prevent rejection of transplanted organs such as kidney, heart or liver, and to treat lupus nephritis, a kidney manifestation of systemic lupus erythematosus. It works by dampening the immune response that can damage the transplanted tissue or the kidneys.

The drug is a pro‑drug that is converted in the body to mycophenolic acid. Mycophenolic acid selectively inhibits the enzyme inosine monophosphate dehydrogenase (IMPDH), which is essential for guanosine nucleotide synthesis in activated T and B lymphocytes. This inhibition blocks DNA synthesis in these cells, reducing their proliferation and suppressing the immune response.

The dosage of Mycophenolate Mofetil Teva is individualized by the prescribing physician based on the specific indication, patient weight, renal function and other clinical factors. The prescriber determines the appropriate strength, frequency and duration of therapy, and patients should follow the written prescription without alteration.

Safety data for Mycophenolate Mofetil in pregnancy are limited and the drug is classified as having unknown pregnancy risk. It is generally avoided in pregnant women because of potential teratogenic effects. Breastfeeding is also not recommended, as the drug can be excreted in milk. Women of child‑bearing potential should use effective contraception and discuss risks with their healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and the necessary import documentation.

The most common alternative to Mycophenolate Mofetil is azathioprine, another antimetabolite. Mycophenolate generally provides more potent and selective inhibition of lymphocyte proliferation with a different side‑effect profile, often resulting in lower rates of certain toxicities such as hepatotoxicity. However, both agents require careful monitoring for bone‑marrow suppression and infection risk.

Mycophenolate Mofetil Teva should be stored at ambient temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture and direct light, and ensure the container is tightly closed. Do not store in a refrigerator or freezer unless specifically instructed by the manufacturer.

The medication is taken orally, usually as whole tablets or capsules. It can be swallowed with water and may be taken with or without food, although taking it with food can reduce gastrointestinal upset for some patients. Doses should be spaced evenly throughout the day as directed by the prescriber.

Serious risks include severe infections due to immune suppression, bone‑marrow suppression leading to neutropenia, anemia or lymphopenia, and an increased long‑term risk of certain malignancies. Patients should promptly report fever, unexplained bruising, persistent diarrhea, or any signs of liver dysfunction, and undergo regular laboratory monitoring as advised by their clinician.

Mycophenolate Mofetil should be avoided in individuals with known hypersensitivity to the drug or its components, in patients with active, uncontrolled infections, and in women who are pregnant or planning to become pregnant without effective contraception. It is also contraindicated in patients with severe renal impairment unless dose adjustments are made under medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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