Product image of Mycophenolsyre Tillomed (Mycophenolic Acid) supplied by GNH India

Mycophenolsyre Tillomed

Active Ingredient:
Mycophenolic Acid
Origin:
EU

Mycophenolsyre Tillomed (Mycophenolic Acid)

Mycophenolic Acid, the active ingredient in Mycophenolsyre Tillomed, is an antimetabolite immunosuppressant presented as an oral formulation for oral use. It is employed to reduce the risk of organ transplant rejection and to manage certain autoimmune disorders such as lupus nephritis and vasculitis, acting primarily on lymphocyte proliferation.

GNH India supplies Mycophenolsyre Tillomed as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, specialty clinics and pharmacies worldwide, with established global reliable robust quality‑assured manufacturing and distribution networks.

Manufacturer / TM Owner

Tillomed Malta Ltd

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Indications & Clinical Uses

Mycophenolic Acid is used to modulate immune activity in conditions where suppression of lymphocyte proliferation is required.

  • Organ transplant rejection: helps prevent acute and chronic rejection by inhibiting immune response to the graft.
  • Lupus nephritis: reduces renal inflammation and proteinuria in patients with systemic lupus erythematosus affecting the kidneys.
  • ANCA‑associated vasculitis: assists in controlling systemic vasculitis by limiting auto‑immune mediated vessel damage.

How It Works

  • Mycophenolic Acid exerts its immunosuppressive effect by selectively and reversibly inhibiting inosine monophosphate dehydrogenase (IMPDH), the key enzyme in the de novo synthesis of guanosine nucleotides. Lymphocytes depend heavily on this pathway for proliferation; blockade of IMPDH depletes guanosine triphosphate pools, thereby preventing DNA synthesis and cell division in activated T and B cells while sparing most other cell types.

Side Effects

Mycophenolic Acid may be associated with a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Gastrointestinal upset: nausea, vomiting, diarrhea, or abdominal discomfort.
  • Infections: heightened risk of bacterial, viral or fungal infections.
  • Hematologic changes: leukopenia, anemia or thrombocytopenia.

Serious or Rare Side Effects

  • Severe opportunistic infection: e.g., Pneumocystis jirovecii pneumonia.
  • Progressive multifocal leukoencephalopathy (PML): rare demyelinating brain disease.
  • Bone marrow failure: aplastic anemia or pancytopenia.

Precautions & Warnings

When prescribing Mycophenolic Acid, clinicians should consider several precautionary measures to minimise risk.

  • Monitor blood counts: regular CBC to detect leukopenia or anemia.
  • Assess renal function: adjust therapy if creatinine clearance declines.
  • Evaluate liver enzymes: periodic LFTs for hepatotoxicity.
  • Avoid live vaccines: increased infection risk makes live attenuated vaccines contraindicated.
  • Pregnancy and lactation: discuss potential risks and consider alternative therapy.
  • Store at ambient temperature: keep below 25 °C in the original container, protect from moisture and light.

Avoid Interactions

Mycophenolic Acid can interact with other medicines, altering its efficacy or safety profile.

Major Interactions (Avoid)

  • Antacids containing aluminum or magnesium: reduce absorption of Mycophenolic Acid.
  • Azathioprine: additive bone marrow suppression.
  • Cyclosporine or tacrolimus: increased mycophenolic acid exposure leading to toxicity.

Moderate Interactions (Monitor Closely)

  • Rifampin: induces metabolism, decreasing drug levels.
  • Valganciclovir: may increase risk of hematologic toxicity.
  • Cholestyramine: may bind and lower drug absorption.

Frequently Asked Questions

Mycophenolsyre Tillomed contains mycophenolic acid, an antimetabolite immunosuppressant used to prevent organ transplant rejection and to treat certain autoimmune conditions such as lupus nephritis and ANCA‑associated vasculitis by inhibiting lymphocyte proliferation.

The drug selectively blocks inosine monophosphate dehydrogenase (IMPDH), an enzyme essential for de novo guanosine nucleotide synthesis. Lymphocytes rely on this pathway for DNA replication; inhibition reduces guanosine pools, thereby suppressing the activation and proliferation of T and B cells.

Dosing is individualized and must be determined by the prescribing clinician based on the specific indication, patient weight, renal function, and concomitant therapies. Patients should follow the exact regimen provided by their healthcare professional.

Safety in pregnancy and lactation has not been fully established. The drug may carry risks to the fetus or infant, and clinicians usually recommend avoiding use unless the potential benefit justifies the potential risk. Women of child‑bearing potential should discuss contraception and treatment options with their physician.

Enquiries are submitted via the product page on gnhindia.com, where you specify the required quantity. GNH India supplies hospitals, pharmacies and procurement teams across international markets, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and the necessary import documentation.

Compared with azathioprine, another antimetabolite, mycophenolic acid provides more selective inhibition of lymphocyte proliferation and often achieves higher efficacy in preventing transplant rejection, though both share risks of bone‑marrow suppression and infection. Choice depends on the clinical scenario, tolerability and physician preference.

Store the product at ambient temperature, preferably below 25 °C, in the original packaging. Protect it from moisture, excessive heat and direct sunlight. Keep the container tightly closed and out of reach of children.

Mycophenolsyre Tillomed is administered orally. The tablets (or capsules, depending on the specific dosage form) are swallowed whole with water, usually twice daily, unless otherwise directed by the prescribing clinician.

Serious adverse events include opportunistic infections such as Pneumocystis jirovecii pneumonia, progressive multifocal leukoencephalopathy (PML), and severe bone‑marrow suppression leading to aplastic anemia or pancytopenia. Prompt medical attention is required if signs of infection, unexplained bruising, or neurological symptoms develop.

Patients with known hypersensitivity to mycophenolic acid or any excipients, those with uncontrolled severe infections, and individuals receiving live vaccines should avoid the drug. Caution is also advised in patients with significant renal or hepatic impairment, and it is contraindicated in pregnancy unless absolutely necessary.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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