Product image of Mycoril (Clotrimazole) supplied by GNH India

Mycoril

Active Ingredient:
Clotrimazole
Origin:
EU

Mycoril (Clotrimazole)

Clotrimazole, the active ingredient in Mycoril, is an imidazole antifungal presented as a topical formulation for skin use. It treats superficial fungal infections such as athlete's foot, ringworm and yeast infections of the skin.

GNH India supplies Mycoril as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Remedica Ltd

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Indications & Clinical Uses

Clotrimazole is an imidazole antifungal used to treat superficial fungal infections of the skin.

  • Dermatophytosis (tinea corporis, tinea pedis, tinea cruris): reduces fungal growth and clears skin lesions.
  • Candidiasis of the skin: eliminates yeast overgrowth and relieves itching.
  • Other superficial fungal infections: controls infection and promotes healing of affected areas.

How It Works

  • Clotrimazole inhibits ergosterol synthesis by binding to and blocking the fungal enzyme lanosterol 14α-demethylase. This disruption prevents the formation of a vital cell membrane component, leading to increased membrane permeability and ultimately halting fungal cell growth and replication.

Side Effects

Topical clotrimazole may cause local skin reactions, ranging from mild irritation to rare systemic effects.

Common Side Effects

  • Skin irritation: redness, burning or itching at the application site.
  • Dryness: mild peeling or flaking of treated skin.
  • Pruritus: transient itching unrelated to infection.

Serious or Rare Side Effects

  • Allergic contact dermatitis: swelling, rash or hives requiring medical attention.
  • Stevens‑Johnson syndrome: severe blistering and mucosal involvement (very rare).
  • Systemic toxicity: rare hepatic or hematologic abnormalities if large areas are treated.

Precautions & Warnings

When using Mycoril, consider the following precautions to ensure safe and effective treatment.

  • Application area: limit use to affected skin and avoid extensive body surface coverage.
  • Duration of therapy: discontinue after clinical resolution, typically 2‑4 weeks, unless directed otherwise.
  • Concomitant skin conditions: avoid use on broken skin, eczema or psoriasis without medical advice.
  • Pediatric use: consult a healthcare professional before applying to children under 2 years.
  • Pregnancy and lactation: safety not established; use only if benefits outweigh potential risks.
  • Store at ambient temperature: keep below 25 °C, protect from moisture and direct sunlight, retain in original packaging.

Avoid Interactions

Clotrimazole may interact with other topical agents or systemic medications.

Major Interactions (Avoid)

  • Concurrent use with other topical antifungals: may increase local irritation.
  • Systemic azole antifungals (e.g., fluconazole, itraconazole): additive inhibition of fungal enzymes, risk of toxicity.

Moderate Interactions (Monitor Closely)

  • Topical corticosteroids: may reduce antifungal efficacy.
  • Occlusive dressings: can enhance absorption and increase irritation risk.
  • Alcohol-based cleansers: may irritate skin when combined with clotrimazole.

Frequently Asked Questions

Mycoril contains clotrimazole, an imidazole antifungal indicated for superficial fungal infections of the skin. It is commonly used to treat dermatophytosis such as athlete's foot, ringworm and jock itch, as well as cutaneous candidiasis and other yeast‑related skin infections.

Clotrimazole blocks the fungal enzyme lanosterol 14α‑demethylase, which is essential for converting lanosterol to ergosterol. By inhibiting ergosterol synthesis, the drug disrupts the fungal cell membrane, increasing its permeability and halting fungal growth and replication.

The specific dosing regimen for Mycoril is determined by the prescribing healthcare professional. Typically, a thin layer is applied to the affected area once to twice daily, and treatment continues for 2‑4 weeks or until the infection has cleared, as directed by the prescriber.

Safety data for clotrimazole in pregnancy and lactation are limited, and the product is classified as pregnancy category unknown. It should only be used if the potential benefit justifies any possible risk to the fetus or infant, and this decision should be made in consultation with a qualified healthcare provider.

To order Mycoril, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request verification of trade or institutional credentials. The team then replies with pricing, availability, shipping details and any necessary import documentation.

Mycoril (clotrimazole) is a broad‑spectrum topical imidazole, offering convenient over‑the‑counter use for many skin fungal infections. Compared with allylamine agents such as terbinafine, clotrimazole has a slightly slower onset but is effective against both dermatophytes and yeasts, making it a versatile first‑line choice for mixed infections.

Mycoril should be stored at ambient temperature, preferably below 25 °C. Keep the product in its original container, protect it from moisture and direct sunlight, and ensure the cap is tightly closed after each use to maintain stability and potency.

Apply a thin layer of Mycoril to clean, dry skin in the affected area. Gently rub it in until it disappears, usually once or twice daily as advised by a healthcare professional. Avoid covering the treated skin with occlusive dressings unless instructed, and wash hands after application.

While most users experience only mild local irritation, serious adverse reactions can include allergic contact dermatitis, severe skin reactions such as Stevens‑Johnson syndrome, and, rarely, systemic toxicity affecting liver or blood cells when large skin areas are treated. Seek immediate medical attention if any severe rash, blistering or systemic symptoms develop.

Mycoril should be avoided in individuals with known hypersensitivity to clotrimazole or any component of the formulation. It is also not recommended for use on extensive broken skin, in patients with severe liver disease, or in pregnant or breastfeeding women unless the potential benefit outweighs the risk and a clinician approves its use.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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