Product image of Mycoril (Clotrimazole) supplied by GNH India

Mycoril

Active Ingredient:
Clotrimazole
Origin:
EU

Mycoril (Clotrimazole)

Clotrimazole, the active ingredient in Mycoril, is an imidazole antifungal presented as a vaginal formulation for local use. It treats vaginal yeast infections caused by Candida species in adult women.
GNH India supplies Mycoril as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Remedica Ltd

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Indications & Clinical Uses

Mycoril, an imidazole antifungal, acts on fungal infections of the genital tract.

  • Vaginal candidiasis: eliminates yeast overgrowth and relieves associated itching, discharge and irritation.
  • Vulvovaginal yeast infection: clears infection and restores normal vaginal flora.
  • Recurrent vulvovaginal candidiasis: helps reduce frequency of episodes when used as prescribed.

How It Works

  • Clotrimazole inhibits the fungal enzyme lanosterol 14α-demethylase, a key step in ergosterol synthesis. By blocking this pathway, the drug disrupts cell membrane formation, leading to increased membrane permeability and ultimately fungal cell death, while having minimal effect on human cells.

Side Effects

Clotrimazole may cause local or systemic adverse reactions.

Common Side Effects

  • Burning or stinging sensation at the application site
  • Vaginal itching or irritation
  • Mild discharge or spotting
  • Unpleasant odor
  • Dryness of the vaginal mucosa
  • Redness of surrounding skin

Serious or Rare Side Effects

  • Severe allergic reaction (anaphylaxis, angioedema)
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis
  • Hepatic dysfunction (elevated liver enzymes)
  • Persistent or worsening infection
  • Unexplained fever or malaise
  • Swelling of the face, lips or tongue

Precautions & Warnings

Before using Mycoril, consider the following safety measures.

  • Hypersensitivity: Do not use if you have known allergy to clotrimazole or other imidazoles.
  • Concomitant infection: Avoid if a non‑Candida vaginal infection is present without medical advice.
  • Pregnancy: Consult a healthcare professional; use only if benefits outweigh potential risks.
  • Breastfeeding: Seek medical guidance before use.
  • Duration: Do not exceed the prescribed treatment period without physician approval.
  • Store at room temperature: Keep below 25 °C in the original packaging, protected from moisture.

Avoid Interactions

Clotrimazole can interact with other medicines, affecting efficacy or safety.

Major Interactions (Avoid)

  • Systemic azole antifungals (e.g., ketoconazole, fluconazole) – may increase systemic exposure.
  • Warfarin – potential increase in anticoagulant effect.
  • Oral contraceptives – possible reduction in hormonal efficacy.

Moderate Interactions (Monitor Closely)

  • Topical corticosteroids – may mask local irritation.
  • Other topical antifungals – risk of additive irritation.
  • Antihistamines – may alter perception of local side effects.

Frequently Asked Questions

Mycoril contains clotrimazole and is indicated for the treatment of vaginal candidiasis, a common yeast infection caused by Candida species. It helps relieve symptoms such as itching, burning, abnormal discharge, and irritation by eliminating the fungal overgrowth.

Clotrimazole blocks the fungal enzyme lanosterol 14α‑demethylase, which is essential for synthesising ergosterol, a key component of fungal cell membranes. Inhibiting this pathway compromises membrane integrity, leading to fungal cell death while sparing human cells.

The dosage regimen for Mycoril is determined by the prescribing healthcare professional. Typically, the product is applied intravaginally for a specific number of days as directed on the label or by a clinician, and patients should follow that guidance exactly.

Safety data for clotrimazole in pregnancy and lactation are limited. It should only be used if the potential benefit justifies any possible risk to the fetus or infant. Women who are pregnant, planning pregnancy, or breastfeeding should discuss use with their healthcare provider.

To order Mycoril, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Mycoril (clotrimazole) and other imidazole antifungals such as miconazole have similar spectra against Candida species. Differences lie mainly in formulation, dosing frequency and local tolerability. Choice of product often depends on physician preference, patient response and specific product availability.

Store Mycoril at room temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly closed when not in use.

Mycoril is applied intravaginally. After washing hands, insert the tablet or apply the cream as instructed, usually while lying down with hips elevated. Remain in that position for a few minutes to allow proper distribution, then resume normal activities.

Although rare, serious adverse reactions can include severe allergic responses such as anaphylaxis, Stevens‑Johnson syndrome, toxic epidermal necrolysis, and significant liver enzyme elevations. Patients should seek immediate medical attention if they experience swelling, rash, fever, or jaundice.

Mycoril should not be used by individuals with a known hypersensitivity to clotrimazole, other imidazole antifungals, or any of the product’s excipients. It is also contraindicated in the presence of a non‑Candida vaginal infection unless directed by a healthcare professional.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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