Product image of Mycostatin (Nystatin) supplied by GNH India

Mycostatin

Active Ingredient:
Nystatin
Origin:
EU

Mycostatin (Nystatin)

Nystatin, the active ingredient in Mycostatin, is a polyene antifungal presented as a topical formulation for external use. It treats cutaneous candidiasis and other superficial fungal infections, providing localized antifungal activity for patients with skin or mucosal involvement in the affected areas.

GNH India supplies Mycostatin as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, with a focus on quality assurance and regulatory compliance. The product is manufactured under EU GMP standards and distributed through a validated cold‑chain logistics network to ensure product integrity.

Manufacturer / TM Owner

Dermapharm Gmbh

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Indications & Clinical Uses

Nystatin is a polyene antifungal used for the treatment of superficial fungal infections affecting the skin and mucous membranes.

  • Cutaneous candidiasis: Reduces fungal load and promotes healing of skin lesions caused by Candida species.
  • Diaper dermatitis (Candida‑related): Relieves inflammation and clears fungal overgrowth in the diaper area.
  • Oral thrush (Oropharyngeal candidiasis): Controls Candida growth on the oral mucosa, easing discomfort and preventing spread.

How It Works

  • Nystatin binds selectively to ergosterol, a key sterol component of fungal cell membranes. This interaction creates pores that increase membrane permeability, leading to leakage of intracellular electrolytes and macromolecules, ultimately causing fungal cell death while sparing human cells that lack ergosterol.

Side Effects

Nystatin is generally well tolerated when applied topically, but adverse reactions can occur.

Common Side Effects

  • Local irritation: Redness, itching, or burning at the application site.
  • Dryness: Mild skin dryness or peeling.
  • Pruritus: Transient itching unrelated to infection.
  • Contact dermatitis: Allergic skin reaction in sensitive individuals.
  • Hyperpigmentation: Temporary darkening of the treated area.

Serious or Rare Side Effects

  • Severe allergic reaction: Swelling, hives, or difficulty breathing.
  • Extensive skin necrosis: Rare tissue damage at the site of application.
  • Systemic absorption leading to gastrointestinal upset (very uncommon).
  • Secondary bacterial infection of the treated area.
  • Persistent ulceration or non‑healing wound.

Precautions & Warnings

When using Mycostatin, consider the following safety measures.

  • Avoid use on extensive broken skin: May increase systemic absorption.
  • Do not apply to eyes or mucous membranes unless directed: Risk of irritation.
  • Monitor for allergic reactions: Discontinue if severe rash or swelling occurs.
  • Use only as prescribed: Overuse can disrupt normal skin flora.
  • Store at room temperature: Keep below 25°C, in the original packaging, protected from moisture and direct sunlight.

Avoid Interactions

Mycostatin may interact with other topical agents or systemic antifungals.

Major Interactions (Avoid)

  • Concurrent use with other polyene antifungals (e.g., amphotericin B): May increase local toxicity.
  • Topical corticosteroids on the same area: Can reduce antifungal efficacy.

Moderate Interactions (Monitor Closely)

  • Systemic azoles (e.g., fluconazole) used concurrently: Monitor for additive antifungal effect.
  • Antiseptic solutions containing alcohol: May cause increased skin irritation.
  • Occlusive dressings over the application site: May enhance absorption and irritation.

Frequently Asked Questions

Mycostatin contains Nystatin and is indicated for the topical treatment of cutaneous candidiasis, Candida‑related diaper dermatitis, and oral thrush. It works by directly targeting fungal cells on the skin or mucous membranes, helping to clear infection and relieve associated symptoms.

Nystatin binds to ergosterol, a sterol unique to fungal cell membranes, forming pores that increase membrane permeability. This disrupts the fungal cell’s internal environment, leading to leakage of essential ions and molecules and ultimately causing cell death while sparing human cells.

The dosage of Mycostatin is determined by the prescribing healthcare professional based on the infection’s location, severity, and patient factors. The prescriber will specify the amount to apply, frequency, and duration of therapy on the product label or prescription.

Safety data for topical Nystatin in pregnancy and lactation are limited. Because systemic absorption is minimal, it is generally considered low risk, but the product should only be used if the potential benefit outweighs any possible risk, as decided by a qualified healthcare provider.

To order Mycostatin, submit an enquiry on the product page at gnhindia.com, indicating the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Mycostatin (Nystatin) is a polyene antifungal that acts locally and is effective against Candida species, whereas azole antifungals (e.g., clotrimazole) inhibit fungal enzyme synthesis. Nystatin is preferred for superficial infections where a non‑systemic, membrane‑disrupting agent is desired, especially in patients with azole resistance.

Store Mycostatin at room temperature, below 25 °C. Keep the product in its original container, protect it from moisture and direct sunlight, and ensure the cap is tightly closed to maintain stability throughout its shelf life.

Apply a thin layer of Mycostatin to the affected skin or mucosal area as directed by the prescriber, typically 2–3 times daily. Wash hands before and after application, and avoid contact with eyes. Do not cover the treated area with occlusive dressings unless instructed.

Serious risks, though rare, include severe allergic reactions such as swelling, hives, or difficulty breathing, and extensive skin necrosis at the application site. If any of these occur, discontinue use immediately and seek medical attention.

Mycostatin should not be used by individuals with known hypersensitivity to Nystatin or any component of the formulation. It is also contraindicated on large areas of broken skin or when systemic antifungal therapy is already in place without medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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