Product image of Mycostatin (Nystatin) supplied by GNH India

Mycostatin

Active Ingredient:
Nystatin
Origin:
EU

Mycostatin (Nystatin)

Nystatin, the active ingredient in Mycostatin, is a polyene antifungal presented as an oral formulation for oral use. It treats fungal infections of the mouth, esophagus and gastrointestinal tract, primarily in patients with candidiasis.
GNH India supplies Mycostatin as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Substipharm

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Indications & Clinical Uses

Mycostatin (nystatin) is indicated for fungal infections affecting the oral and gastrointestinal pathways.

  • Oral candidiasis (thrush): reduces fungal load and relieves symptoms such as white plaques and discomfort.
  • Esophageal candidiasis: helps eradicate Candida species in the esophagus, improving swallowing and reducing pain.
  • Intestinal candidiasis: controls overgrowth of Candida in the gut, alleviating abdominal discomfort and diarrhea.

How It Works

  • Nystatin binds to ergosterol, a key sterol component of fungal cell membranes, creating pores that increase membrane permeability. This disruption leads to leakage of essential intracellular ions and molecules, ultimately causing fungal cell death without significant interaction with human cell membranes.

Side Effects

Nystatin may cause adverse reactions that vary in frequency and severity.

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Vomiting: occasional episodes after dosing.
  • Diarrhea: loose stools during treatment.
  • Abdominal cramps: discomfort in the stomach area.
  • Mouth irritation: transient burning or soreness.
  • Skin rash: localized itching or redness.

Serious or Rare Side Effects

  • Severe allergic reaction: hives, swelling, or difficulty breathing.
  • Hepatotoxicity: abnormal liver function tests.
  • Nephrotoxicity: signs of kidney impairment.
  • Hematologic changes: unexplained bruising or low blood counts.
  • Persistent gastrointestinal bleeding.
  • Severe mucosal ulceration.

Precautions & Warnings

Before using Mycostatin, consider the following safety measures.

  • Assess renal function: adjust use if significant impairment exists.
  • Evaluate hepatic status: monitor liver enzymes during prolonged therapy.
  • Pregnancy: avoid unless benefits outweigh risks, as safety data are limited.
  • Breastfeeding: consult a healthcare professional before use.
  • Concomitant antibiotics: monitor for possible overgrowth of resistant organisms.
  • Store below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Mycostatin can interact with other medicines, requiring attention to potential effects.

Major Interactions (Avoid)

  • Amphotericin B: combined use may increase nephrotoxicity.
  • Cyclosporine: heightened risk of renal impairment.

Moderate Interactions (Monitor Closely)

  • Oral antibiotics (e.g., ampicillin): may alter gut flora and affect efficacy.
  • Antacids containing aluminum or magnesium: could reduce absorption.
  • Oral contraceptives: monitor for reduced effectiveness.
  • Proton pump inhibitors: possible impact on gastric pH and drug activity.

Frequently Asked Questions

Mycostatin, containing nystatin, is used to treat fungal infections such as oral thrush, esophageal candidiasis, and intestinal candidiasis. It works by targeting Candida species in the mouth, esophagus and gastrointestinal tract, helping to clear infection and relieve associated symptoms.

Nystatin binds to ergosterol in fungal cell membranes, forming pores that increase membrane permeability. This leads to leakage of essential intracellular components, causing fungal cell death while sparing human cells that lack ergosterol.

The appropriate dose of Mycostatin is determined by the prescribing clinician based on the specific infection, patient age, weight and renal or hepatic function. Dosage instructions are provided on the prescription label and should be followed exactly.

Safety data for nystatin in pregnancy and lactation are limited. Mycostatin should only be used if the potential benefit justifies any possible risk to the fetus or infant, and this decision should be made by a qualified healthcare professional.

To order Mycostatin, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Mycostatin (nystatin) is a polyene antifungal that acts locally in the gastrointestinal tract, unlike systemic azoles such as fluconazole which are absorbed and distributed throughout the body. Nystatin is often preferred for superficial or localized Candida infections because it has minimal systemic absorption and a distinct safety profile.

Mycostatin should be stored below 25 °C, in its original packaging, and protected from moisture. Keeping the product in a cool, dry place helps maintain its stability and potency throughout its shelf life.

Mycostatin is taken orally as directed by a healthcare professional. The formulation may be a liquid suspension or tablet; it should be swallowed with water or mixed with a suitable vehicle as indicated on the prescription label.

Serious risks, although rare, include severe allergic reactions such as anaphylaxis, hepatotoxicity, nephrotoxicity, and significant hematologic abnormalities. Patients should seek immediate medical attention if they experience symptoms like difficulty breathing, swelling, jaundice, dark urine or unexplained bruising.

Mycostatin should be avoided in individuals with known hypersensitivity to nystatin or any component of the formulation. Caution is also advised for patients with severe renal or hepatic impairment, and it should be used only under medical supervision in such cases.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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